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Biomedical subjects

H Nakazaki

Publications and source records attributed to H Nakazaki.

23 records · Page 2Linked to original sources
PubMed1988

Concentrations of alpha-1-antichymotrypsin and other acute phase reactants in patients with gastric cancer.

The serum levels of alpha-1-antichymotrypsin, immunosuppressive acidic glycoprotein, acid soluble glycoproteins, and sialic acid as acute phase reactants (APRs) and carcinoembryonic antigen (CEA) as a cancer-producing glycoprotein were measured preoperatively in 245 patients with gastric cancer who underwent gastrectomy and were treated with postoperative adjuvant chemotherapy or immunochemotherapy. The patients were classified into four groups: group A had normal leverl of serum CEA and APRs; group B had abnormal CEA levels; group C had normal levels of CEA and one or more abnormal levels of APRs; and group D showed abnormal levels of CEA and one or more abnormal levels of APRs. Groups A and B showed good survival rates, but groups C and D had poor rates. The patients in groups A and C who received immunochemotherapy exhibited significantly better survival rates than those treated with chemotherapy. The pretreatment of levels of CEA and APRs have potential as aids in prognosis and in the selection of suitable immunopotentiators and anticancer drugs for cancer patients.

Acute-Phase Proteins↗
PubMedDate not supplied

Quintuple carcinomas with metachronous triple cancer of the esophagus, kidney, and colonic conduit following synchronous double cancer of the stomach and duodenum.

A patient who had undergone radical gastrectomy for synchronous gastric cancer (T(1)N(0)M(0), stage I) and duodenal cancer (Tis, stage 0) in November 1987 was found to have esophageal cancer in November 1994, and underwent radical thoracolaparotomy at our hospital (T(1)N(0)M(0), stage I). After follow-up for about 3.5 years, renal cancer was detected in April 1998, and radical nephrectomy was performed (T(1)N(0)M(0), stage I). Two years later, in April 2000, the patient was found to have a polypoid lesion in the colonic conduit used for reconstruction after esophagectomy, and endoscopic mucosal resection was performed (Tis, stage 0). The patient remains under careful follow-up, including observation of the colonic conduit and the residual large intestine.

Adenocarcinoma↗
PubMedDate not supplied

CT-guided percutaneous laser disk decompression (PLDD) for cervical disk hernia.

OBJECTIVE: Percutaneous laser disk decompression (PLDD) is an effective treatment for bulging or protruding disk. The aim of this study was to present a method of PLDD for cervical disk hernia under CT guidance and to evaluate the efficacy and safety of this procedure. MATERIALS AND METHODS: Seven patients with radiculalgia caused by cervical disk hernia were treated overnight by PLDD. A laser fiber was inserted through an 18 G needle into the target disk under CT guidance. A Nd-Yag laser (1,064 nm) was used for ablation. A CT scan was obtained every 60 joule (J) at the slice of the target disk to visualize the vaporized area during the procedure. The Japan Orthopedic Association (JOA) score of cervical radiculopathy (full score 15) and MacNab criteria were used for assessment of treatment response. RESULTS: Puncture of the needle to the target disk was safely performed under CT guidance. The total dosage of laser ablation ranged from 120 to 500 J (average, 266 J). The overall success rate according to MacNab criteria was good in all cases. No complications were observed in our series. CONCLUSION: The CT-guided technique provides safe, accurate PLDD for cervical disk hernia. PLDD for cervical disk hernia shows promise in the management of radiculalgia.

Cervical Vertebrae↗