PubMed Health⌕ Search

Biomedical subjects

H Nambu

Publications and source records attributed to H Nambu.

At least 37 records · Page 2Linked to original sources
PubMed1995

Variations in the numbers of phalangeal bones in the four-toed salamander, Hynobius tenuis (Amphibia: Hynobiidae), from two localities in Toyama Prefecture, Central Japan.

Variations in the numbers of phalangeal bones in the fingers (I to IV) and toes (I to V) of specimens of Hynobius tenuis collected from two localities (Ashikuraji and Arimine) in Toyama Prefecture, Central Japan, were recorded. In the case of fingers of fore limbs, eight phalangeal formulas were distinguished, and in the case of toes of hind limbs, ten phalangeal formulas were recognized. In the fingers of specimens from Ashikuraji, the predominant formulas were 2-2-3-2 (40%) and 2-2-3-1 (32%). In specimens from Arimine, 2-2-3-2 was predominant (75%). In toes, the predominant formula was 2-2-3-2-0- (96%) for Ashikuraji and 71% for Arimine. The maximal number of phalangeal bones, 2-2-3-3-2, found in the toes of specimens from Arimine seems to represent the fundamental formula in hynobiid salamanders. The predominant formula, 2-2-3-2-0-, observed in the two populations may have been derived from the fundamental formula by degeneration of the phalangeal bones in the fourth and the fifth toes. The reason why phalangeal bones were degenerated in this species is discussed from an ecological viewpoint of body growth.

Animals↗
PubMed1991

Crossed polydactyly type I in a mother and son: an autosomal dominant trait?

In a Japanese family, a propositus and his mother had crossed polydactyly type I. A maternal grandaunt also had preaxial polydactyly of the feet. The findings that both of the mother and son had the identical type of polydactyly are consistent with an autosomal dominant inheritance with variable expressivity. Other explanations include X-linked recessive inheritance, polygenic inheritance, and a chance occurrence of the 2 different kinds of polydactyly.

Adult↗
PubMed1991

Use of drugs during pregnancy in Japanese women.

The use of drugs during pregnancy was studied in 890 women, who were delivered of their babies in 11 obstetric departments of general hospitals in Japan, during the one month period of November 1989. Of these women, 889 (99.9%) took one or more drugs during the whole period of pregnancy and the number of drugs taken averaged 9.6. During pregnancy 172 women (19.3%) did not take drugs, and the remaining 718 (80.7%) took a total of 1766 medications. The most commonly used drugs were anti-anemic, anti-abortion medications, digestives, and antimicrobials. Bronchodilators, psychotropic agents, anticonvulsants, and steroids were each prescribed during pregnancy for about 1% of the women. Malformations were found at birth in 12 infants (1.3%). No significant relations were found between these anomalies and ingestion of particular drugs. During pregnancy, 9.3% of the women continued to smoke, and 1.9% continued to consume moderate amounts or more of alcohol. (Tab. 8, Ref. 7.)

Abnormalities, Drug-Induced↗
PubMed1979

[Respiratory distress in the newborn (author's transl)].

Diseases which manifest with the respiratory distress in the newborn include 1) respiratory diseases-IRDS, type II RDS, neonatal asphyxia, and MAS etc. 2) anemia, CHD 3) CNS and 4) metabolic diseases. Among these, IRDS has high mortality rate because of the lack of the pulmonary surfactant and immaturity of respiratory center, and has many difficult problems in terms of its prevention and respiratory management. The points of its respiratory management are as follows: 1) Estimation of the level of arterial oxygen ation-this is the most important point. It has become possible, these days, to monitor continuous oxygenation using a transcutaneous oxygen electrode. 2) Knowledge of the physiology & management of apnea, and monitoring of heart rate and respiration. 3) Correction of acidosis & anemia and the nutritional supply by the intraveonous fluid administration. 4) Airway maintenance. 5) Oxygen administration to main PaO2 or tc PO2 of 60--80 mmHg. 6) Artificial ventilation by CPAP or IMV and 7) The specific drug therapy includes indomethacin for PDA associated with IRDS, Tolazoline for the fetal circulation syndrome, and Xanthine derivatives for primary apnea. 8) However, improvement by exchange transfusion has been contro-versial. On the other hand, in the type II RDS which has a relatively good prognosis, the intact survival can be expected by means of the proper management of general condition and respiration. In MAS, pneumothorax, pneumomediastinum and severe asphyxia, the proper resuscitation, oxygen administration should be given according to several conditions, especially the degree of hypoxia. The peritoneal dialysis can be lifesaving in case of severe renal impairment with RD. As the respiratory distress in the newborn is very frequent in its occurrence and death rate, its proper management is expected to result in the decrease in the newborn death rate in Hokkaido (8.1--6.6 per 1,000 live births) and the increase in the survival rate without any handicap, particularly if hospitals in each Hokkaido district give the newborn medical care more intensively than at present.

Humans↗
PubMed1977

The effects of oral alanine administration on blood glucose, pyruvate, lactate, serum glucagon and insulin in human newborns.

Alanine (500 mg/kg body weight) was given orally to 27 healthy full term newborn infants, and the changes in blood glucose, pyruvate, lactate, alanine, glucagon and insulin were determined. Significant increments in blood glucose were found in 15 infants with blood glucose levels below 60 mg/100 ml, 4 of whom showed significant elevation of serum glucagon levels on day 1. This observation suggests that hepatic gluconeogenesis is possible immediately after birth.

Age Factors↗
PubMed1975

Convulsion following intrathecal cephaloridine.

Following therapeutic intrathecal administration of cephaloridine to an 11-day-old premature infant with suspected meningitis, a generalized tonic convulsion was observed. Symptoms continued to subside over the next six hours, followed by postictal sleep. That convulsion and other symptoms were due to cephaloridine was confirmed when the second intrathecal administration produced the same symptom. Because of its possible damaging effect on CNS, it is strongly suggested that cephaloridine should not be administered directly into the cerebrospinal fluid space.

Cephaloridine↗
PubMed1974

Clinical application of cytochrome a(plus a3) assay of mitochondria from liver specimens: an aid in determining metabolic tolerance of liver remnant for hepatic resection.

Measurement of cytochrome a(+a(3)) contents in liver mitochondria was made on 52 biopsy specimens of patients with liver tumor. Patients having higher cytochrome a(+a(3)) contents in mitochondria from remaining liver than those of normal human liver mitochondria could survive well major liver resections whether or not associated with liver cirrhosis. However, patients with cytochrome a(+a(3)) contents less than 0.5 x 10(-10) moles per mg protein showed a high rate of postoperative complication (80%) and death (40%) in spite of minor operation. In routinely used liver function tests such as serum albumin, A/G ratio, SGOT, total bilirubin, prothrombin time, BSP and TTT, there were no significant differences between patients with cytochrome a(+a(3)) contents more than 0.5 x 10(-10) moles per mg protein and those less than 0.5. The results indicate that routine laboratory studies do not have much diagnostic value in estimation of a marked decrease of mitochondrial cytochrome a(+a(3)) contents. It is suggested that the measurements of cytochrome a(+a(3)) of the remnant liver should be done prior to a contemplated major resection.

Adolescent↗
PubMedDate not supplied

Cataractogenesis in neonatal Sprague-Dawley rats by N-methyl-N-nitrosourea.

Cataract was induced by a single intraperitoneal injection of 100 mg/kg N-methyl-N-nitrosourea (MNU) to 0-, 5-, 10-, 15-, or 20-day-old male and female Sprague-Dawley rats. In day 0, 5, 10, and 15 MNU-treated rats, mature cataracts were constantly seen 7, 14, 14, and 30 days after dosing, respectively. In the day 20 MNU-treated rats, only subcapsular cataract was seen 30 days after dosing. Therefore, the rats exposed to MNU at an earlier age caused cataract more rapidly and severely. In the day 0 MNU-treated rats, 7-methyldeoxyguanosine DNA adduct was detected in the lens epithelial nuclei 12 hours after MNU dosing, followed by apoptosis, which was confirmed by morphology, by TUNEL signals, and by DNA ladder and peaked 3 days after MNU dosing. In the apoptosis cascade, upregulation of Bax, downregulation of Bcl-2, and increased CPP32 protease (caspase-3) activity were seen 12 hours after MNU dosing. Therefore, the pathogenesis of MNU-induced cataract was associated with DNA adduct formation in the lens epithelial cell nuclei leading to apoptosis by upregulation of Bax protein, downmodulation of Bcl-2 protein, and activation of caspase-3.

Animals↗
PubMedDate not supplied

N-methyl-N-nitrosourea-induced photoreceptor apoptosis in the mouse retina.

Retinal degeneration induced by a single intraperitoneal injection of N-methyl-N-nitrosourea (MNU) in male and female albino (GRS/A and DDD/1) and colored (C57BL) mice at 7 weeks of age was examined morphologically 1, 3, 7, 14 and 21 days after the treatment. A dose of 60 mg/kg body weight evoked progressive retinal degeneration in all mice. All albino and colored mice had a comparable progression of photoreceptor cell degeneration by an apoptotic mechanism, as confirmed by morphological and TUNEL methods. Apoptosis had already taken place 1 day after the treatment and was completed by Day 7. This process resulted in a thin remnant of retina with complete loss of photoreceptor cells-21 days after the treatment. During the course of apoptosis, the pigment epithelial cells were maintained in a continuous layer in all strains of mice. In colored mice, several layers of the swollen pigment-enriched cells were seen between the inner nuclear layer and the pigment epithelial layer 14 and 21 days after the treatment. In summary, the destruction of photoreceptor cells by the apoptotic process was the mechanism by which retinal degeneration was induced by MNU.

Animals↗