PubMed Health⌕ Search

Biomedical subjects

H Neumann

Publications and source records attributed to H Neumann.

At least 91 records · Page 5Linked to original sources
PubMed1976

[The determination of the sum potential amplitude for the prognostication of facial paresis of viral etiology].

In 29 patients with facial pareses of viral etiology the sum potential amplitude of the M. orbicularis oris was determined in a comparison of the two sides for prognostication purposes. If the sum potential amplitude is reduced by less than 70 per cent a return of good functions can be expected within 6-8 weeks. If the reduction of the sum potential amplitude lies between 70 and 95 per cent, a reliable prognosis is not possible, whereas with values below 95 per cent the paresis does not improve at all or hardly improves within 6-8 weeks. An evaluation of the returned function, about 1 year after the beginning of the paresis, i.e. at a time when the regeneration is basically completed, shows that all cases with an originally poor function (judged 6-8 weeks after onset of paresis) had changed into cases with a moderate function, and all cases with an originally moderate function had turned into cases with a good function. In another study concerning patients with idiopathic facial paresis the same method yielded results comparable to those of the above-mentioned study, so that the conclusion can be drawn that in the prognostication of the peripheral facial paresis by means of determining the sum potential amplitude-regardless of whether the facial paresis is of viral or idiopathic etiology-the same yardsticks have to be applied.

Action Potentials↗
PubMed1976

[Determination of the latency for the prognosis of Bell's palsy (author's transl)].

In a previous study the authors discussed the value of the determination of the compound action potential amplitude of the m. orbicularis oris following supramaximal stimuli of the facial nerve for the prognosis of facial paresis. In this study they investigate the suitability of the determination of the latency periods for an early prognosis. The latency periods in 20 normal subjects and 26 patients with idiopathic facial paresis were messured and continuously checked. The study reveals that a difference of more than 0.5 msec. between the latency periods of normal and paretic patients does not even permit the proof of peripheral lesions in patients with partial denervation or absent or insufficient recovery. Ocassionally, even shorter latency were observed in paretic patients, which are probably due to a local increase of the threshold for supramaximal stimuli around the stimulation electrode. The necessary increase of the stimulus intensity probably leads to a nervous excitation further distally. Contrary to the observations of other authors these studies indicate that the determination of the latency does not constitute a useful prognostic criterion for idiopathic facial paresis; for an early prognosis the measurement of latency is less reliable than the determination of the compound action potential amplitude.

Electric Stimulation↗
PubMed1976

[Experiences gained in the treatment of oto- and rhinogenic meningitides, 1965-1975 (author's transl)].

The studies permit the conclusion that morbidity and mortality due to purulent oto- or rhinogenic meningitides have not essentially changed over the past eleven years despite antibiotics that are more effective and can be given in higher doses than so far. Resistent strains of bacteria, allergies and insufficient antibiotic therapy are probable causes for that fact. Under certain circumstances a sufficient and specific antibiotic therapy may delay surgical intervention or make it even unnecessary. Advanced age and additional diseases seem neither to influence operability nor to increase morbidity.

Adolescent↗
PubMed1976

[Cytostatic therapy in oto-rhino-laryngology (author's transl)].

The report covers the therapeutic results achieved after using cytostatic drugs in 104 patients treated at the 1st Oto-Rhino-Laryngological Univ. Hospital, Vienna, between 1967 and 1975. The breakdown according to the tumor histology shows that squamous cell carcinomas accounted for the highest per centage, i.e. 53%; laryngeal tumor prevails according to the tumor localization. In 42 patients it was not possible to positively influence the disease; 45 patients showed a disruption or a slowdown of the progress of the disease; in 17 patients all measurable criteria of the disease receded (classification according to Karnofsky). Even if the average survival time after the commencement of the therapy amounted to only about 6 months, it was nevertheless possible to positively influence the progress of the disease by means of cytosatic therapy.

Adenocarcinoma↗
PubMed1976

[Study on the role of personality factors for successful lithium long-term therapy (author's transl)].

20 female manic-depressive out-patients who had been treated with lithium over a long period (average time = 4.3 years), were submitted to a psychoanalytic interview and a personality test (FPI). The interview focussed to changes in personality with special regard to the rise of novel impulses and conflicts. The severity of neurotic conflicts as well as the frequency of specific events preceding a relapse were investigated. The results suggest that a subgroup of out-patients should be given psychotherapy in addition to long-term lithium-treatment. This hypothesis will be tested in a further investigation.

Bipolar Disorder↗
PubMed1976

Dose-dependent kinetics of diethylstilbestrol in the rat.

Diethylstilbestrol (DES) acts as a transplacental carcinogen with organotropic properties. The question is raised whether the pharmacokinetics of DES contribute to this effect. [3H] DES was administered to female Wistar rats orally, intravenously, and introperitoneally at doses ranging from 0.025 to 25 mg/kg. Radioactivity associated with erythrocytes and plasma proteins was measured and the pattern of unconjugated metabolites and glucuronides after column and thin-layer chromatography in blood determined. The different routes of administration resulted in different metabolite patterns. After iv injection, unconjugated, unpolar metabolites predomininated; after ip injection, glucuronides of unpolar metabolites; and after oral administration, unconjugated polar metabolites. The different compositions of the glucuronide fractions remained constant with time. The composition of the unconjugated metabolites changed with time after oral administration but not after iv injection. Blood levels of metabolites did not increase proportionally with dose. Overproportional increase was most prominent with the highest dose used. The observed effects are explained with intestinal metabolism and a liver first-pass effect.

Animals↗
PubMed1975

The reaction of tris (hydroxymethyl) aminomethane with calf intestinal alkaline phosphatase.

The effect of tris (hydroxymethyl) aminomethane concentrations on the rate of calf intestinal alkaline phosphatase-catalyzed hydrolysis of p-nitrophenyl phosphate was studied, in the pH range 8-10, where no transphosphorylation reaction could be detected. Kinetic analysis of the results permitted description of the effect of Tris concentrations T on the rate of enzyme catalyzed hydrolysis (V) by the following equation: (see article). The rate-accelerating effect of Tris concentrations can be ascribed to two different mechanisms: At moderate Tris concentrations (0.01-0.20 M) the enzyme forms a reversible addition complex with a Tris molecule. This complex has an enhanced catalytic activity. We suggest that the binding of Tris to the enzyme could potentiate a second active site of the enzyme, due to its ionization effect upon an acidic group of the enzyme of pK = 8.9. The modest linear rate accelerating effect of Tris at high concentrations (0.20-0.60 M) could be ascribed to the change of the dielectric constant of the medium, the degree of solvation of the protein, or change in the tertiary structure of the enzyme.

Alkaline Phosphatase↗
PubMed1975

[The treatment of the "mobile" vocal cord carcinoma: cordectomy versus irradiation (author's transl)].

In the literature, cordectomy and irradiation each give an about 80% 5-year cure rate in cases of stage I carcinoma of the vocal cords. Between 1955 and 1969 49 patients were cordectomized and 71 patients were subjected to irradiation (5-year absence of recurrence in 75%) and 68.8% of cases respectively. 6 out of 9 criteria are in favour of cordectomy and only 3 in favour of radiotherapy in a comparison of both forms of treatment. In favour of cordectomy: 1. Direct examination of the tumour. 2. Immediate histological control during the operation. 3. Duration of treatment: 7 to 10 days (irradiation: 4 to 5 weeks). 4. Short healing period. Irradiation may entail chronic after effects. 5. Perichondritis: not observed after operation but may follow irradiation. 6. Treatment of tumour recurrence: After cordectomy: non-irradiated area and, if required, full radiation dose possible or operation in ordinary tissue. After irradiation: full radiation dose not possible, operation only in irradiated tissue. In favour or irradiation: 1. Medical contra-indications to surgery. 2. Tracheotomy: required prophylactically in case of cordectomy for 1 to 3 days, usually not necessary in case of irradiation. 3. Voice quality: Clearly better after irradiation than after operation. Irradiation is preferable in patients who have to use their voice very much. The problem should be thoroughly discussed with the patient. In general, cordectomy is the treatment of choice.

Electrocoagulation↗
PubMed1975

[Total laryngeal extirpation in tumour recurrence following chordectomy (author's transl)].

A review of 18 cases of laryngectomy on account of tumour recurrence following chordectomy revealed a high incidence of post-operative salivary fistulae. The tumour recurrence was extensive, as seen from the extirpated larynx specimen, in spite of regular laryngological check-up examinations. Tumour recurrence rends to be localized in the anterior commissure and sometimes infiltrates into the prelaryngeal area. The poor long-term prognosis is stressed.

Glottis↗
PubMed1975

Photoreactions of phosphorothioate and cysteamine-S-phosphate. Photosubstitution and photophosphoryl transfer.

The photoreactions of phosphorothioate and cysteamine-S-phosphate were investigated. On irradiation of phosphorothioate a marked change in absorption spectrum was observed. The product migrated in high voltage electrophoresis, with different mobility from that of phosphorothioate and its dimer, or inorganic orthophosphate. It contained phosphate and sulfur in a ratio of 2: 1, without reducing properties. Therefore it was suggested that the product is either pyrothiophosphate, or a cyclic compound, with similar composition. On irradiation of phosphorothioate in the presence of potential phosphoryl group acceptor, such as glucose or galactose, 25-40% of the phosphoryl group was transferred. The formation of glucose 6-phosphate, or galactose 6-phosphate was observed. The photolysis of cysteamine-S-phosphate gave cysteamine, inorganic orthophospate and taurine. Under the same conditions of irradiation, inorganic orthophosphate or aminoethanol-O-phosphate were found to be stable.

Cysteamine↗
PubMed1975

Preference for basic IgG in early syphilis.

By differential IgG measurements of sera of 27 patients with early infectious syphilis, it was found that infection with T. pallidium results in a preferential synthesis of IgG immunoglobulins characterized by high isoelectric points. The decrease in total IgG level observed after 6 weeks of treatment can to a large extent be accounted for by the decrease in basic IgG concentration. The relationship between the total and basic IgG levels and the number of T. pallidum present in the body during the three early stages of the disease studied is discussed.

Adult↗
PubMed1975

[Electrophysiological studies on the prognosis in idiopathic facial paralysis].

The literature on electrophysiological techniques used so far for the prognostication of idiopathic facial palsies contains reports on 31 patients with idiopathic facial palsy, in whom - after electric stimulation of the nervus facialis at the point where it exits from the foramen stylomastoideum - the amplitude of the compound muscle action potential of the M. orbicularis oris was measured. The extent of the SPA's decline was related to the progress of the disease. In those cases where the SPA declined by at least 75-100 per cent, the palsy regressed either in an unsatisfactory manner or not at all. However, where the decline amounted to at most 67 per cent a restitutio ad integrum took place or residual symptoms which do not disturb the patients were found. The prognosis can be made between the 5th and 10th day after the palsy has developed. If in cases of idiopathic palsy the diagnosis is made at an early date, this method is more reliable than any other technique.

Action Potentials↗
PubMed1974

Distinct alkaline phosphatase in serum of patients with lymphatic leukemia and infectious mononucleosis.

A distinct alkaline phosphatase (phosphatase N) was demonstrated in the serum of patients with acute lymphatic leukemia, chronic lymphatic leukemia, and infectious mononucleosis. This enzyme closely resembles that extracted from the thymus of mice with lymphoma or lymphatic leukemia, both in its electro-phoretic mobility and its substrate specificity. The phosphatase N activity was related to the clinical state of patients with lymphatic leukemia and disappeared with recovery from infectious mnononucleosis.

Adolescent↗