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Biomedical subjects

H Niibe

Publications and source records attributed to H Niibe.

At least 145 records · Page 8Linked to original sources
PubMed1986

[Therapeutic cranial irradiation in patients with metastatic brain tumors from pulmonary carcinoma].

Fifty-three patients with intracranial metastases from pulmonary carcinoma were treated with cranial irradiation between 1976 and 1983. There was improvement in neurologic symptoms in 80%, and the one and two-year survival rates for the entire group of patients were 21% and 4%. Those or patients without metastasis tumor in other organs were 38% and 9%, respectively. It was suggested that the total dose should be in excess of 40 Gy. Histologically, adenocarcinoma and epidermoid carcinoma showed better prognosis than other types of cancer.

Adenocarcinoma↗
PubMed1986

[The effects of PS-K on long-term survival of uterine cervical cancer patients treated with radiation].

The effects of PS-K on long-term survival of uterine cervical cancer patients treated with radiation was studied. The patients receiving PS-K were anxious about curability more or less at the time of completion of radiation therapy. Between 1977 and 1983, out of 96 patients with stage III, IV uterine cervical cancer treated with radiation, 27 were given PS-K as adjuvant therapy. The number of cases with PS-K administration were 15 (23%) out of 64 in stage IIIb, seven (37%) out of 19 in stage IVa and five (38%) out of 13 in stage IVb. Out of 27 patients administered PS-K, 19 were given the agent within three months after irradiation and the remaining eight after recognition of recurrence or metastasis. As a rule, PS-K was given orally, 3.0 g per day, intermittently in the pattern of two weeks per month. Judgement of the effects of PS-K was made in comparison with the survival rate of the patients with and without PS-K, and then by observation of the changes of the PPD skin test, ESR, appetite and body weight as early effectiveness of PS-K. The results were as follows. Obvious prolongation of survival was recognized in the patients with PS-K after irradiation. Namely, the cumulative five-year survival rates of stage IIIb were 65% and 49% with and without PS-K, respectively. Improvement by PS-K as early effectiveness was obtained in seven cases (37%) out of 19. The conditions necessary for long-term survival with PS-K were thought to be as follows: that the tumor almost disappears as a result of irradiation and that the condition of the host is superior to that of the tumor in the tumor-host relationship. The effectiveness of intermittent administration of PS-K was suggested.

Aged↗
PubMed1985

Radiation therapy of rat brain tumor using misonidazole as hypoxic cell sensitizer.

Rat brain tumor was used as a model to evaluate radiation therapy with and without misonidazole. BD-IX rats were implanted intracerebrally with an ethylnitrosourea-induced glioma. Three series of experiments were performed, with radiation given 14 days after inoculation of the glioma clone. In each series, the following radiation doses were given: 500 rads once, 1,000 rads once; and 1,000 rads twice, every time with or without two different doses of misonidazole. Radiation therapy significantly prolonged survival when compared to the longevity of the control group. The dose of 1,000 rads given twice was highly effective and the life-span of tumor-bearing rats increased from 72% to 121%. Misonidazole plus irradiation negated the prolongation of survival, achieved with radiation therapy alone.

Animals↗
PubMed1985

[Possibility of complete eradication of early esophageal cancer by radiotherapy alone].

Twenty-five patients with esophageal cancer less than 5 cm in length receiving radical radiotherapy alone were studied to consider the radicality of this therapy for early esophageal cancer. The relative five-year survival rate for the 25 patients was 41%, which was better than 23% for 60 patients receiving radical radiotherapy and many reported results. And for 11 stage I patients, a five-year survival rate of 79% could be obtained. Summing up Japanese results reporting survival rates by tumor length revealed that crude five-year survival rates were 21.5% for tumors less than 5 cm and 4% for tumors more than 5 cm long, respectively. Radiotherapy can be considered to be among the effective modalities for the treatment of early esophageal cancer.

Aged↗
PubMed1985

[CT and pathologic studies on detecting hepatic involvement of malignant lymphoma].

In order to determine the value of CT in detecting lymphomatous involvement of the liver, 57 autopsied cases (48 cases of non-Hodgkin lymphoma and 9 of Hodgkin's disease) were analyzed in detail. Additionally, 90 recent cases of abdominal CT with liver study in the initial staging were reviewed and 6 cases in which the liver had been examined within 2 weeks before autopsy were compared for macroscopic and pathologic findings. The following results were obtained. Autopsy findings in 57 cases of malignant lymphoma. (1) Hepatic involvement was demonstrated in 56% of the patients with non-Hodgkin lymphoma and in 67% of those with Hodgkin's disease. Of these patients with hepatic involvement, intrahepatic nodular lesions over 1.0 cm in diameter were macroscopically identified in 22% of the cases of non-Hodgkin lymphoma and 33% of those with Hodgkin's disease. Lymphomatous involvements were seen in many organs in the cases of hepatic involvement. CT examinations of 90 cases for the initial staging showed no significant abnormality in the liver or spleen. Of the 6 cases in which the liver was examined by CT within about 2 weeks before autopsy, lymphomatous involvement was pathologically diagnosed in 5. Of these, only one having multiple nodules larger than the tip of a thumb was correctly diagnosed by CT. Hepatic involvement of lymphoma was thought to be the end stage, and minimal or early disease was detected in the region of Glisson's capsule. The above findings indicate that early hepatic involvement is not likely to be detected by CT at the present time.

Aged↗
PubMed1985

[A case of liver metastasis from a testicular tumor indicated by unreasonable CT findings--correlation of CT and autopsied specimen].

A 48-year-old men died of liver metastases from a left testicular tumor and was autopsied. It is thought to be rare for a pure seminoma of the testis to metastasize to the liver in the form of a large solitary nodule and for no obvious difference to be seen on plain and enhanced CT in the low-density area. These findings are unreasonable in view of the characteristic proliferative patterns of the tumor. Thus, the correlation between CT and the autopsied specimen was studied histopathologically with the purpose of understanding the focal conditions. The following results were obtained. A large low-density area in the right lobe of the liver on CT coincided with the autopsied specimen, and small nodular lesions scattered in the necrotic tissues were seen. The lesion was diagnosed to be metastasis from the testicular tumor and it was almost the coagulative necroses of the tumor cells in the histologic examination. Moreover, severe tumor thrimbi were observed in the blood vessels with special reference to metastatic foci. Above findings indicating the articular ischemic condition in the region of metastatic foci made it possible for the CT findings to be reasonably understood.

Dysgerminoma↗