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H Nishihara

Publications and source records attributed to H Nishihara.

At least 73 records · Page 4Linked to original sources
PubMed1989

[Studies on the ultrastructure of the inner limiting membrane of the retina. I. Surface replication study on the inner limiting membrane of the retina].

In order to clarify the ultrastructural details, electron microscopic observations of the inner limiting membrane (ILM), critical point drying and surface replication methods with collagenase digestion were performed on rabbit's ILM. The results were as follows,: 1) This method was simple, the electron microscopic image is highly reproducible and a bird's-eye view of the ILM is possible. 2) The ILM was composed of a fine three-dimensional meshwork structure with numerous pores (sieves). 3) The diameter of the pores varied from 10 to 25nm. Mean diameter of the pores is 13.43nm in the visual streak, 13.59nm in the medullary ray, 13.40nm in the peripheral retina, and there were no statistical differences among these three regions. 4) In the peripheral retina, it was difficult to observe the ILM because vitreous fibrils lay densely on it. The pore's shape in the peripheral retina was different from that in the posterior pole retina. These results may provide the morphological basis for the theory that the pores of the ILM act as the main filtration barrier between the retina and the vitreous cavity. It is supposed that the bulk of substances are transported from the retina mainly through the ILM of the posterior pole, because dense vitreous fibrils of the peripheral retina disturb that transport.

Animals↗
PubMed1988

[An autopsy case of esophageal cancer with brain metastasis].

A rare case of esophageal cancer with brain metastasis is reported. A 54-year-old man complaining of dysphagia was admitted to our hospital. Endoscopic and radiographic examinations revealed an advanced esophageal cancer with supraclavicular lymph node metastasis. Five months later, muscle weakness of right upper extremities developed. A brain CT scan revealed a low density area with a ring enhancement in the left front parietal region. The patient developed right hemiplegia and delirium, and died seven months later. Autopsy findings showed a hematogenous metastasis of the left precentral gyrus, measuring 3.0 x 2.5 x 2.5 cm.

Brain Neoplasms↗
PubMed1986

[A case of CSF (colony-stimulating factor)-producing lung cancer and a review of the literature].

A 36-year-old man with large-cell carcinoma of the lung showed marked leukocytosis of up to 109,300/mm3. As high CSF activity was detected in the pleural effusion and the supernatant of cell cultures originating from the effusion, a diagnosis of CSF-producing lung cancer was made. Twenty-one CSF-producing lung cancers have been reported in Japan. They comprised 13 large-cell carcinomas, six squamous cell carcinomas, one adenocarcinoma and one small cell carcinoma.

Adult↗
PubMed1986

[A double-blind comparative study on the efficacy of S6472, cefaclor, in the treatment of bacterial bronchitis].

Clinical efficacy and safety of S6472 (long active cefaclor (CCL)) and CCL were compared by a double-blind study using 248 patients with bacterial bronchitis. Patients were orally administered with either 375 mg of S6472 2 times or 250 mg of CCL 3 times daily for 7 days, and the following results were obtained. Clinical efficacy judged by a committee: The efficacy rates on acute bronchitis were 87.2% for S6472 and 82.6% for CCL, and the efficacy rates on chronic bronchitis were 70.3% for S 6472 and 64.7% for CCL. There was no significant difference between the 2 drugs in clinical efficacy. Clinical efficacy judged by doctors in charge: Results of the clinical efficacy judged by doctors in charge were similar to the efficacy judged by the committee. Bacteriological efficacy judged by the committee: Eradication rate for the S6472 group was 71.1% (32 of 45 patients) and that for the CCL group was 67.4% (29 of 43 patients). There was no significant difference between the 2 drugs in the bacteriological efficacy. Side effects and abnormal laboratory findings: Side effects were observed in 5 cases (4.2%) in the S6472 group and in 5 cases (4.0%) in the CCL group. These side effects, however, were not serious, and no remarkable abnormal laboratory values were observed. There was no significant difference between the 2 drugs in the incidence of side effects or abnormal laboratory findings. Clinical utility: When the clinical utility was expressed by the utility rate (very useful and useful), it was 79.5% in the S6472 group (117 patients) and 76.2% in the CCL group (122 patients) (judged by the committee). When the utility was judged by doctors in charge, it was 73.3% in S6472 group (120 patients) and 71.4% in CCL group (126 patients). From the above results, it has been concluded that S6472 taken twice daily is equivalent to CCL in effectiveness on bacterial bronchitis.

Adult↗
PubMed1985

Evaluation of local blood flow velocity in proximal and distal coronary arteries by laser Doppler method.

A high resolution laser Doppler velocimeter using an optical fiber was developed to evaluate detailed characteristics of phasic blood flow in the coronary artery. Local blood flow velocities were measured in the proximal (0.27 +/- 0.05 cm i.d.) and the distal portion (0.09 +/- 0.02 cm i.d.) of the left circumflex coronary artery of anesthetized, open-chest dogs. The velocity waveform in the central axial region of the vessel and the velocity profile across the vascular lumen were compared in the proximal and the distal portions.

Animals↗
PubMed1984

Production of monoclonal antibodies that recognize specific and cross-reactive antigens of Bacteroides gingivalis.

Four monoclonal antibodies directed against Bacteroides gingivalis were established by hybridoma technology. Their reactivity against B. gingivalis, Bacteroides intermedius, and Bacteroides melaninogenicus was detected by the enzyme-linked immunosorbent assay. Three monoclonal antibodies specifically reacted with B. gingivalis. One recognized antigens that were cross-reactive between B. gingivalis and B. intermedius. These monoclonal antibodies provide new tools for antigenic analysis of B. gingivalis.

Antibodies, Bacterial↗
PubMed1980

Epidemiologic and preventive studies of rubella in female office workers.

In order to prevent maternal rubella infection, serum antibody titers for rubella were estimated in a total of 965 female office workers residing in the vicinities of Tokyo and Osaka using hemagglutination-inhibition test. Approximately 40% of the young women tested were then observed to be susceptible to the disease, and the percentage was not apparently changed by a large rubella epidemic which occurred while our research proceeded, suggesting the necessity to attain immunization in the suceptible before pregnancy. By our surveillance on the occurrence of rubella infection over one-year period among the women having received the serologic test, we found a particular case, where a titer of 1 : 8, being considered to be the immunized level, had been determined. The finding indicates that vaccination should be aimed at the persons having the titer of 1 : 8 as well as of less than 1 : 8. Attenuated live rubella-virus vaccine was administered to 42 volunteers susceptible to the disease, and their serum titers were estimated again about one year after the inoculation. Then, the vaccination proved effective in 41 of the vaccinees but one who was found still susceptible by unknown reason.

Adult↗