PURPOSE: The purpose of this work was to evaluate the correlation of tumor angiogenesis and dynamic CT in lung adenocarcinoma. METHOD: Thirty-five consecutive patients with lung adenocarcinoma underwent dynamic chest CT. Maximum attenuation of dynamic CT was compared with microvessel densities (MVDs) and vascular endothelial growth factor (VEGF) expression by immunohistochemistry. RESULTS: The mean peak attenuation (A(PA)) of lung adenocarcinoma correlated with MVD (r = 0.689, p < 0.0001). VEGF positiveness of lung adenocarcinoma was 63%. There was a significant difference in A(PA) between VEGF-positive and -negative lung adenocarcinomas (39.9 +/- 3.9 and 24.3 +/- 2.3; p < 0.05). The mean MVDs of VEGF-positive adenocarcinomas were significantly higher than those of negative ones (82.5 +/- 5.9 and 49.2 +/- 7.1; p < 0.05). The mean A(PA) of VEGF-positive lung adenocarcinomas correlated positively with MVD (r = 0.707, p < 0.0001). CONCLUSION: The A(PA) value of dynamic CT reflects MVD in lung adenocarcinoma. The A(PA) value of dynamic CT might be an index for VEGF-related tumor angiogenesis.

Adenocarcinoma↗

PubMedDate not supplied

Hemosuccus pancreaticus: CT manifestations.

A case of severe gastrointestinal bleeding due to rupture of a splenic artery aneurysm into the pancreatic duct (hemosuccus pancreaticus) was encountered. Contrast enhanced CT revealed a low-density mass containing an enhancing central area in the pancreatic tail. Arteriography demonstrated a splenic artery aneurysm. Postoperative pathological review revealed a communication between the ruptured splenic artery aneurysm and the pancreatic duct.

Aneurysm↗

PubMedDate not supplied

Early diagnosis of small peripheral lung cancer--cytologic diagnosis of very fresh cancer cells obtained by the TV-brushing technique.

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Adenocarcinoma↗

PubMedDate not supplied

A case of a solitary metastatic diaphragmatic tumor--relation to the peritoneal stomata of the diaphragm.

We herein describe a metastatic diaphragmatic tumor, an entity that has rarely been reported radiologically. The primary lesion was advanced colon cancer, and the root of the metastasis was thought to be the peritoneal stoma(ta) of the diaphragm, which has previously been shown to absorb both intraperitoneal fluid and small particles.

Adenocarcinoma↗