Properties of a reconstituted vitamin D3 25-hydroxylase from rat liver mitochondria.
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Adrenal Glands↗
Biomedical subjects
H Oftebro
Publications and source records attributed to H Oftebro.
The presence of an adrenodoxin-like ferredoxin and cytochrome P-450 in brain mitochondria.
An iron-sulfur protein has been isolated from bovine brain mitochondria and purified 200-fold. The optical spectrum (peaks at 412 and 455 nm which disappear upon reduction) and the EPR spectrum (g values at 1.94 and 2.02) were typical for a ferredoxin. In reconstitution experiments, the protein could replace adrenodoxin in the cholesterol side chain cleavage reaction. The additional detection of cytochrome P-450 in brain mitochondria indicates that the isolated ferredoxin is part of a cytochrome P-450-dependent hydroxylation system.
Adrenodoxin↗
Isolation from bovine liver mitochondria of a soluble ferredoxin active in a reconstituted steroid hydroxylation reaction.
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Animals↗