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Biomedical subjects

H Ortlieb

Publications and source records attributed to H Ortlieb.

12 recordsLinked to original sources
PubMed1990

[Bronchial cancer and asbestos: comparison of anamnestic exposure to asbestos, detection of asbestos bodies in bronchoalveolar lavage and in lung tissue].

The histories of 19 surgical patients with carcinomas of the lungs were examined for exposure to asbestos, and the patients investigated with BAL and lung tissue analysis for the presence of AB. In 63% there was a history of occupational exposure to asbestos; in 47% there was an above-average asbestos load in the lung tissue. In 22% of the patients with exposure to asbestos, the BALF was positive. The asbestos content of lung tissue was appreciably higher than that of a published control group with no carcinoma of the lungs, on the basis of post-mortem material.

Adenocarcinoma↗
PubMed1989

[The effect of mass chest x-ray on early detection of bronchial cancer].

On 30.6.1983, mass radiographic screening was abandoned despite objections to the effect that it offered the only chance of detecting carcinoma of the lung at an early stage. In a retrospective analysis of our patient material comprising 1.010 patients with bronchial carcinomas seen within the period between 1.1.1980 to 31.12.1986, we investigated the question as to whether these objections might not be justified. Four hundred and thirty-seven patients seen prior to 30.6.1983 were compared with 537 patients examined after this date, on the basis of the following parameters: age - sex - symptomatology - cancer stage - histology - treatment. After stopping mass radiographic screening, an increase in age and symptomatic tumour findings was observed, and thus a shift towards more advanced stages of carcinoma. A relative decrease in the number of squamous cell carcinomas, and a relative increase in the number of adenocarcinomas were observed. All the parameters in the patients identified at mass radiographic screening were comparable with those seen in patients identified incidentally. In comparison with symptomatic patients, those identified by mass radiography screening more frequently presented with earlier tumour stages, and the lesions were more frequently resectable. All in all, over a period of three and one-half years, mass radiographic screening revealed 23.8% of all cancers of the lung, and 36.8% of all resectable lesions. After the abandonment of mass radiographic screening, an increase in more advanced and symptomatic tumours was observed.

Carcinoma, Bronchogenic↗
PubMed1989

[Prognostic factors in diffuse malignant mesothelioma of the pleura].

Diffuse malignant pleural mesothelioma (DMM) is associated with a very poor prognosis and is only partially accessible to treatment. On the basis of a retrospective analysis, we made an attempt to identify possible factors that influence the prognosis. Between 1964 and 1986, 84 evaluable patients were treated: the ratio of male to female patients was 4.3:1, their average age being 58.5 +/- 11.9 (range: 21-82 years). The tumour types included 50% epithelial, 38% biphasic, and 12% mesenchymal tumours. The classification in accordance with the suggestions of Butchart revealed: I 10%, II 89%, III 0%, IV 1%. In 32% of the patients, treatment was purely symptomatic, in 42% a palliative surgical procedure with decortication of the tumour and tumour-pleurectomy was performed, while in 26% the palliative procedure was followed by adjuvant chemotherapy using doxorubicin and cisplatin. The median survival for the patients overall was 253 days. Parameters that were found not to correlate with the prognosis were: age, sex, exposure to asbestos, use of tobacco, pleural effusion, and growth behaviour in the thymus aplastic nude mouse. A significant influence was found for the histological type of the tumour and therapy administered, epithelial and biphasic tumour forms, as also surgical and combined surgical/chemotherapeutic treatment resulting in a more prolonged survival. On the basis of these results, surgical therapy should always be employed, despite the fact that there is almost always no curative option; postoperative adjuvant therapy is capable of further improving the prognosis.

Adult↗
PubMed1988

[Castleman's lymphoma. Differential diagnosis of mediastinal tumors].

This report describes two cases of Castleman's disease (male 48 yrs, female 33 yrs). Two intrathoracic lymphomas were accidentally discovered during routine x-ray examination. Histologically, follicular hyperplasia, prominent interfollicular vascularity and sheets of mature plasma cells (intermediate variant) were seen. The etiology of this benign lymphoma remains unknown. Its significance lies in its differential diagnosis from malignant tumours.

Adult↗
PubMed1986

[Primary management of newborn infants with respiratory failure due to a congenital defect of the diaphragm].

The authors report on 36 premature and term infants with congenital defects of the diaphragm, including 17 patients who developed a severe respiratory insufficiency either immediately after birth or during the first 30 minutes of life. The overall mortality rate was 64%; the results of treatment were marked by a particularly high mortality rate among the patients with early respiratory insufficiency: out of 17 patients, 12 died. The evaluation of the courses confirmed that adequate preoperative primary care is of major prognostic importance in patients with early respiratory insufficiency. On the basis of personal experience the authors have formulated the following recommendations for improving diagnosis and therapy at this stage of care: greater use of sonography examination methods for antepartal diagnosis of congenital defects of the diaphragm, making it possible to treat the corresponding high-risk pregnancies at an early stage in clinics equipped for neonatologic and pediatric surgical treatment; early intubation respiration with a ventilation technique which does not overstrain the patient, in newborns with abnormal respiration and suspected congenital defects of the diaphragm; the great diagnostic importance of plain radiographs of the thorax and abdomen; neonatologic and intensive medical stabilization treatment in patients with severely suppressed metabolism prior to the anesthesiologic and surgical stress of closure of the diaphragm defect.

Critical Care↗
PubMed1980

Reaction of N-n-butyl-N-nitrosourea with DNA in vitro.

N-n-[1-14C]Butyl-N-nitrosourea was synthesized from n-[1-14C]butanol and incubated at physiological conditions (pH 7.2; 37 degrees C) with calf thymus DNA in vitro. Following mild acid hydrolysis, purine bases were separated by Sephadex G-10 and cation exchange chromatography. 3-n-Butyladenine, 7-n-butylguanine and O6-n-butylguanine were identified as major reaction products. The O6-/7-butylguanine ratio was 0.69, indicating that the relative extent of oxygen alkylation by n-butylnitrosourea is similar to that produced by ethylnitrosourea.

Adenine↗