PubMed Health⌕ Search

Biomedical subjects

H Ortmans

Publications and source records attributed to H Ortmans.

At least 19 recordsLinked to original sources
PubMed1987

Prognostic relevance of serum inhibitory factors (SIF) in protracted and persistent hepatitis B.

In a follow-up study of 3 years' duration, serum inhibitory factors (SIF) were analysed in 23 patients with a protracted course of viral hepatitis B (PVH) and 12 patients with chronic persistent hepatitis (CPH). Four patients showed a progressive course, developing chronic active hepatitis, and one died of liver failure. All 4 patients had high and persisting SIF activity. The other patients were either SIF negative or lost SIF during the observation period. The inhibitory moiety was isolated from an albumin-rich serum fraction, indicating that the factor was of the same nature as previously described in patients with acute viral hepatitis B. SIF was also demonstrated in other viral infections but was absent or of low activity in autoimmune, toxic or nutritive disorders. These results suggest that SIF may act as an immunoregulatory molecule protecting the liver from exaggerated immune response.

Autoimmune Diseases↗
PubMed1979

Deficiency of antibody formation to HBsAg in the pathogenesis of chronic hepatitis and cirrhosis?

UNLABELLED: Sera of 832 healthy persons and patients suffering from chronic inflammatory liver disease were investigated by radioimmunoassay for HBsAg and anti-HBs. Diagnosis in patients was secured by biopsy. The persons were divided into: 1. Healthy persons: n = 478 blood donors, hospital especially exposed to HBV, patients with healed hepatitis; 2. PATIENTS: n = 354 acute hepatitis, chronic persistent and aggressive hepatitis, post-hepatitic, cryptogenic and alcoholic cirrhosis. The results demonstrate considerable accumulation of HBsAg in chronic liver disease (72% in CAH, 66% in posthepatic liver cirrhosis) whereas anti-HBs was more frequently observed in healthy persons (38% in hospital staff, 49% in healed hepatitis). Furthermore, HBsAg and anti-HBs were frequently observed simultaneously in chronic hepatitis and cirrhosis (23% in CAH). A strong shift in the relation of antigen to antibody to the disadvantage of antibody in the examined collectives of chronic hepatitis and cirrhosis is evident. Chronic inflammatory HBsAg positive liver disease should therefore be regarded as chronic virus infection. We suppose an absolute or relative deficiency of antibody to HBsAg is probably an important factor for the development of chronicity of hepatitis B.

Chronic Disease↗
PubMed1978

[Rupture of postoperative adhesions and hemorrhage--a rare complication of peritoneoscopy (author's transl)].

A case report is given of a patient, who had been operated upon because of gall stones before; the gall bladder had not been removed. At a later date peritoneoscopy was planned and gas insufflated into the abdominal cavity in the usual manner; the patient did not complain about anything particular during peritoneoscopy. However adhesions apparently having formed after the earlier operation between the spleen and the abdominal wall did rupture during this procedure leading to a continously oozing hemorrhage from the spleen. At surgery 3 1 of blood were found in the abdominal cavity and splenectomy became unavoidable. This case report is given in order to draw attention to this sort of complication of peritoneoscopy.

Female↗
PubMed1976

[Relevance of biochemistry in diagnosis and development of alcoholic liver disease (author's transl)].

In a group of 205 patients with alcoholic diseases of liver the diagnostic relevance of biochemical tests (GOT, GPT, AP, GGTP, BSP) was reconsidered with discriminatory process (separation of diagnosis). The group contained 16 patients with nutritional-caused and 41 cases with alcoholic-caused fatty-infiltration of liver. 148 patients showed a toxic chronic liver disease; 52 a chronic hepatitis and 96 cirrhosis of liver. Laparoscopy and morphology guaranteed the clinical diagnosis and therefore the accuracy of biochemistry in separation of diagnosis was given. The biochemical tests were not able to offer a separation of fatty-infiltration with reference to cause, changes of the process in toxic hepatitis and cirrhosis were announced. Intersection in several cases was noticed and biochemical tests were not able to substitute endoscopy and morphology for clinical and diagnostic use in all cases. In every regard the enzyme-tests,--above mentioned--, and determination of sulfobromthalein are aptly to development of diseases and deficiency of alcohol.

Alanine Transaminase↗
PubMed1976

[The diagnostic significance of immunoglobulin determination in chronic liver diseases. III. observations of progress (author's transl)].

55 patients with chronic aggressive hepatitis and 20 with liver cirrhosis were observed over a 2-year period. Liver biopsy was performed several times but no immunosuppressive therapy was carried out. In this way a comparison was made between biochemically and histomorphologically demonstrable alterations in the process with the immunoglobulins. Significant agreement between the clinical biochemical and histomorphological activities and the behavior of immunoglobulin can only be concluded from increased activity of the process. But in histological deterioration, no correlation to the immunoglobulins was established, with the exception of IGM.

Adult↗
PubMed1975

[The diagnostic significance of immunoglobulin determination in chronic liver diseases. II. Relationships between immunoglobulin changes and degree of activity (author's transl)].

The relationship between the immunograms and aminotransferases, gamma-GT and AP were examined in 715 patients with hepatobiliary diseases closely confirmed by histomorphological criteria and a series of 60 normal subjects. The normal subjects showed positive relationships. These are largely lacking in acute and protracted courses and in chronic aggressive hepatitis. Only relationships of the individual immunoglobulins between themselves can be demonstrated in the aggressive chronic types. Positive relationships are present between immunograms and aminotransferases, gamma-GT and AP in the group with fatty livers, and so are other highly significant positive relationships in toxic hepatitis and toxic cirrhoses of the liver.

Acute Disease↗
PubMed1975

[The diagnostic significance of immunoglobulin determination in chronic liver diseases. I. Differential diagnostic accuracy of immunoglobulin changes and enzyme activities (author's transl)].

715 patients with hepatobiliary diseases came for examination, who because of the morphological findings are classified in diagnostic groups. The immunoglobulin measurements of IGG, IGA, IGM were determined and assessed in combination with enzymatic investigations of GOT, GPT, AP and GGTP. Typical group-specific changes were only found in primary biliary liver diseases and toxic cirrhoses of the liver, all acute or chronic inflammatory liver diseases could not be separated and by inference from the final diagnosis showed great errors in classification. Data on the raised mean levels of immunoglobulins in the individual diagnostic groups were demonstrable, but the range limits were so widely scattered that their differential diagnostic valence is of no consequence. Immunoglobulins may appear to be of interest for the observation of the course of liver diseases, but they are unsuitable for diagnostic purposes.

Acute Disease↗
PubMed1975

[Prognosis of cirrhosis of the liver (15-year follow-up from time of first manifestation (author's transl)].

114 patients with cryptogenic or "hepatitic" cirrhosis of the liver (toxic or biliary causes excluded) were followed for a period of 15 years. The time of first manifestation of the disease was known because all patients had been in hospital or under serial outpatient observation, with clinical and biopsy studies every six months for chronic hepatitis. In addition, diagnosis of the liver cirrhosis was confirmed by laparoscopy and histomorphology, which further confirmed the exact timing of first manifestation. In 37 patients (32.5%) the disease healed out completely by way of reactionless fibrosis after, in some of them, a long period of observation, while in 47 (41.2%) the active disease continued, and 30 (26.3%) died in liver coma or bleeding from varices or surgical shunt procedures or from carcinoma of the liver. Prognosis of cirrhosis of the liver is thus much better than previously thought.

Chronic Disease↗