Biomedical subjects
Publications and source records attributed to H Otaya.
Simple and practical dose equations for oral administration and intravenous infusion are derived by means of pharmacokinetics. These equations have no troublesome parameters for adsorption of drug on protein in blood, as these are eliminated with the help of information obtained by the pilot dosing.
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The correlation between the clinical effectiveness and ratio of blood concentration to minimum inhibitory concentration of sulfamethoxazole against Escherichia coli isolated from clinical specimens were studied. This value is one of important parameters in a dosage equation by the pharmacokinetics, it showing sigma in an equation, were determined by clinical trial for acute simple cystitis of women. The sigma values were justified as 4 or more.