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Biomedical subjects

H Oura

Publications and source records attributed to H Oura.

At least 127 records · Page 7Linked to original sources
PubMed1982

Metabolic effects of dietary purine in rats.

The effect of different dietary purines on the metabolism of serum and urinary uric acid, allantoin, creatinine, urea nitrogen and urea was examined in the rat. Experimental diets were synthetic and they were given ad libitum during a 6-day experimental period. The results were compared with the renal morphological changes. The results obtained were as follows: Hypoxanthine, inosine, guanosine and guanine were readily converted to uric acid and allantoin, whereas adenine was metabolized quite differently from other purines. In particular, the intake of adenine exhibited a decrease of the uric acid excreted in the urine. Furthermore, an increase of creatinine, urea nitrogen and urea in the serum as well as a reduction in their urine excretion were observed in rats fed on the adenine diet. Adenine produced a nephrotoxic condition as reflected in the histological changes. From these observations, it is concluded that although the administered purines are closely related structurally, they are metabolized in so many different ways that some of the metabolites, particularly of adenine, may cause a potential nephrotoxicity.

Adenine↗
PubMed1979

Stimulation of pituitary-adrenocortical system by ginseng saponin.

Effects of preparations of saponin mixture and isolated ginsenosides, extracted from the root of Panax ginseng, on plasma corticotropin (ACTH) and corticosterone concentrations in rats were determined by the radioimmunoassay and competitive protein binding method. When ginseng saponin mixture was administered to rats intraperitoneally, plasma ACTH and corticosterone increased significantly 30, 60 and 90 min after the treatment. The kinetic pattern of the increase in plasma ACTH was almost parallel to that in plasma corticosterone. Isolated ginsenoside, protopanaxadiol or protopanaxatriol glycoside, also increased plasma corticosterone. The ginseng-induced increase in plasma corticosterone was suppressed by pretreatment with dexamethasone. Thus the ginseng saponin was found to act on the hypothalamus and/or hypophysis primarily, and stimulated ACTH secretion which resulted in increased synthesis of corticosterone in the adrenal cortex.

Adrenocorticotropic Hormone↗
PubMed1979

Features of ginseng saponin-induced corticosterone secretion.

Ginseng saponin administered intraperitoneally to rats induced a significant rise in plasma corticosterone, while it tended to increase plasma glucose and to decrease plasma immunoreactive insulin. Oral or intraperitoneal administration of ginseng saponin increased plasma corticosterone in unanesthetized, pentobarbital-anesthetized or alloxan-diabetes rats. The histamine-induced rise in plasma corticosterone was suppressed by pretreatment with diphenhydramine, whereas the ginseng-induced rise was not. Ginseng saponin decreased rectal temperature while it increased plasma corticosterone. Ginseng-induced corticosterone secretion was superimposed on the basal levels of plasma corticosterone due to fasting and circadian rhythm. Thus ginseng saponin would be a kind of stressful agent and have different features associated with the stimulation of the pituitary-adrenocortical system from several other chemical agents.

Animals↗