[Polysomes and protein synthesis].
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Biomedical subjects
Publications and source records attributed to H Oura.
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In diabetic rats given ginsenoside-Rb2 for 6 days, nitrogen balance was studied. Ginsenoside-Rb2 was found to suppress the total urinary excretion of nitrogen, increase nitrogen retention in the body, and thereby improve nitrogen balance.
Urinary excretion of prostaglandin E2 showed a significant increase following administration of magnesium lithospermate B [1] in rats with renal failure. In contrast, that of thromboxane B2 showed a significant decrease, indicating the improvement of renal failure.
In streptozotocin-induced diabetic rats given 10 mg/day of ginsenoside-Rb2 for 3 days, there was no significant increase in the serum protein and albumin levels, whereas a significant increase in these parameters was found in rats given the ginsenoside-Rb2 for 6 days. When the state of protein biosynthesis was determined using [14C] leucine, significantly activated protein biosynthesis was found in rats given ginsenoside-Rb2 for 3 days, indicating the presence of an activated state of protein biosynthesis prior to the evident quantitative increase.
Blood lipid levels in rats with hyperlipidemia resulting from high-fat feeding were determined after ip administration of an MeOH extract of Prunus davidiana stems and its flavonoid components, (+)-catechin, prunin (= naringenin 7-O-glucoside), and hesperetin 5-O-glucoside. Administration of the MeOH extract for 3 days produced a significant decrease of blood triglyceride and total cholesterol, and the atherogenic index was also improved. (+)-Catechin was shown to be effective in reducing the elevated level of triglyceride. Prunin and hesperetin 5-O-glucoside did not show such an effect in high-fat-fed hypertriglyceridemic rats, but they did exhibit a significant hypocholesterolemic effect.