Correlation between plasma malondialdehyde and ceruloplasmin activity values in preeclamptic pregnancies.
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Biomedical subjects
Publications and source records attributed to H Ozgüneş.
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The element Zn is the metal component or activator of many important enzymes. The tissue concentrations and activities of Zn metalloenzymes direct the rate of protein and nucleic acid syntheses, thereby influencing tissue growth and reperative processes. Most of the serum Zn is normally bound to circulating proteins. Low serum Zn concentrations might result from depletion of Zn-binding proteins. Serum protein and Zn concentrations have been reported to be depressed in patients with acute and chronic diseases. We compare the serum protein and Zn values of patients with thoracic empyema (n = 20) with those of a control group (n = 20). The values obtained in the empyema group were significantly lower than those in the control group before the study. Test group administered 220 mg zinc sulfate (ZnSO4.7H2O) over 20 d and there was a significant increase in the values for serum protein and Zn after the oral administration of the zinc sulfate.
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The tear and serum zinc (Zn) levels were determined simultaneously by atomic absorption spectrophotometry in 11 healthy subjects. The mean tear Zn level was found to be 1.537 +/- 0.146 (SEM) ppm while the mean serum Zn level was found to be 1.03 +/- 0.046 (SEM) ppm.
Serum ceruloplasmin activity, serum copper and zinc levels were determined in 20 patients aged 19-43 with normal pregnancies of first trimester (5-9 weeks) admitted to hospital for legal abortion. Blood samples were taken from each patient 30 min before and 3 h after induced abortion. Significantly reduced ceruloplasmin activity (P less than 0.01) and serum copper level (P less than 0.05) were observed following induced abortion while zinc level didn't demonstrate any significant change (P greater than 0.05). A high degree of correlation was observed between the ceruloplasmin activity and the serum copper level (r = 0.87). Ceruloplasmin activity and serum copper values seem to be an index of feto-placental function in early pregnancy.