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Biomedical subjects

H P Fortmeyer

Publications and source records attributed to H P Fortmeyer.

At least 55 records · Page 3Linked to original sources
PubMed1979

[Xenotransplantation of human breast cancer in athymic nude mice].

Of 150 human breast cancers, 90 (60%) were successfully transplanted onto thymusaplastic nude mice without the use of adjunctive immunosuppressive therapy. Four months after transplantation, 12 rapidly growing tumors had diameters of 2.5-3.5 cm. Investigations revealed a high correlation between the histology of original tumors and xenografts. We conclude that the nude mouse may be used as an animal model for studies such as this, or in determining the sensitivity of transplanted tumors to cytostatic drugs, steroid hormones, and radiation.

Animals↗
PubMed1977

Human mammary cancers in nu/nu-mice. A model for testing in research and clinic.

37 (85%) of 44 human breast cancers are successfully transplanted on thymus-aplastic nu/nu-mice without adjunctive immunotherapy. 16 weeks after transplantation 4 rapidly growing tumours are showing human, female karyotypes. Subsequent investigations proved a good correlation between original tumour and transplant: histology, 3H-thymidine marking index and receptors of androgen and estorgen.

Animals↗