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Biomedical subjects

H P Schiffer

Publications and source records attributed to H P Schiffer.

At least 19 recordsLinked to original sources
PubMed1979

[Comparative study between timolol and pilocarpine in the treatment of open-angle glaucoma (author's transl)].

Timolol, a beta-blocker with special influence on aqueous humor production and less influence on outflow facility lowered the intraocular pressure after one single local application for more than 12 hours. Normal diurnal variations of the intraocular pressure were also observed. Fifty open-angle glaucoma patients from the University of Münster, Eye Clinic, took part in a comparative study between Timolol and Pilocarpine. For a period of 17 weeks the patients were given various concentrations of Timolol ophthalmic solution. The continual lowering of the intraocular pressure following Timolol application was noted in 88% of the patients, whereas the rate of success on only 56% could be recorded with Pilocarpine. Side-effects, which for the Pilocarpine-treated patients were very irritating, e. g. miosis with possible night-blindness, accommodation spasms, myopia, etc. were not observed with Timolol. Pupil diameter and pupillary reaction remained unchanged with the application of Timolol. Changes of blood pressure and pulse were not evident. A detrimental influence on the corneal transparency could not be observed in any patient.

Double-Blind Method↗
PubMed1978

[Results of Nandrolone therapy (Keratyl) in lesions and diseases of the cornea (author's transl)].

The authors report on clinical experiences with the topical application of the synthetic hormone Nandrolon (Keratyl) in diseases of the cornea caused by exogenic, neurogenic, and combined exogenic-endogenic factors. In all cases a positive regenerative effect on epithelium and stroma of the cornea seemed to exist. The present results seem to allow the following range of indications: 1. injuries of the epithelial tissue; 2. ulcera of the cornea (combined with antibiotics); 3. dystrophic diseases of the cornea; 4. certain postoperative treatment after keratoplastic surgery.

Chemical Phenomena↗
PubMed1978

[Metastatic deposits of carcinoma in the choroid (author's transl)].

The authors report on choroid metastatic deposits from primary tumors of other organs with regard to a survey of the literature and personal observations. 85% of the choroid secondary growths occur after breast cancer in women with an average latency of 3 1/2 years. The ophthalmological appearances and the fluorescence-angiographical phenomena are discussed with regard to the differential diagnosis of melanoma and haemangioma of the choroid. The therapeutic procedure for secondary deposits of mamma carcinoma is considered.

Breast Neoplasms↗
PubMed1978

[On the conservation of the tear ducts in tumor surgery in the eyelid region (author's transl)].

The conservation of the tear ducts, as well as their partial conservation, must be considered when operating on smaller tumors, depending on the clinical picture and the histological aspect. However, the preparation should be done under magnification to facilitate delineation of the borders of the tumor and to immediately recognize when the tear ducts are opened. The histological description of the kind of tumor and the answer to the question of excision into the healthy tissue decide the further procedure. The placing of an indwelling tear duct probe in the form of a supramid thread or of a polyethylene tube has proved favorable. In case partial resection of the peripheral parts of the canal system is necessary, the remains of the posterior wall of the vertical or horizontal part of the canaliculus must be opened with Vanna's scissors. The remaining vertical or horizontal part of the canaliculus does not lose its suctionpressure pump capillarity when it is opened, but ensures tear drainage.

Adult↗
PubMed1977

[Spinalioma in the eyelid region (author's transl)].

The authors describe the characteristic features of spinaliomas in the lid region, which were observed in a study of 44 patients with this clinical picture. From this we could conclude that the presence of a spinalioma is revealed by: atypical localisation in the eyelids (upper lid, lateral or medial lid angle), accelerating rate of growth or involvement of youngerer patients. And, certainly not in the last position of importance, there is a very definite inclination to recurrences, which necessitates a sufficiently radical surgical removal into the healthy tissue.

Adult↗
PubMed1977

[Ophthalmological long-term effects of malar fractures (author's transl)].

In the years 1964 to 1974 138 patients with malar fractures were treated by operation. After follow-up examination on an average of 3 years and 10 months after the operations the occuring complications in 61 patients were revealed. On the first stationary admission to hospital 14 patients complained of diplopia; on the follow-up examination only 5 paresiae were found. On the first examination after the accident 35 patients had hypoaesthesiae, anaesthesiae or paraesthesiae in the area of supply of the ophthalmic and maxillary nerves. It is remarkable that in the follow-up examination 29 patients complained still of these disturbances. Perforating injuries were not found in these patients. 2 patients had however traumatic macular foramina. 2 further patients had partial optic atrophy, a result of fracture in the region of the optic canal.

Accidents, Traffic↗
PubMed1977

[On the therapy of tractional retinal detachment without hole formation (author's transl)].

The authors describe 6 cases of tractional retinal detachment without hole formation--five as a result of intraocular metal splinter injuries and the sixth after scleral perforation following windshield injury which was overlooked. Splinter extraction was performed twice through the perforation and three times though the pars plana from the ouside. The time between the injury and appearance of the retinal detachment varied between four months and nine years. In every case there was a diffuse falt detachment without obvious tent formation. Reattachment was successful in five cases by release of the traction from the outside by cerclage with folding of the point of traction in the vitreous body and diathermy with drainage of the subretinal effusion. This method described gives relief only when vitreous strands traverse the whole bulbus crosswise. The follow-up period is up to the present three months to a year.

Adolescent↗
PubMed1976

Renal disease in pregnancy.

Renal biopsy was obtained in 11 primiparous and 9 multiparous patients with severe pre-eclampsia. The large number of patients with renal disease allowed for single-case evaluation. Eclamptic convulsions and fetal deaths were observed in association with renal disease without foci of additional primary glomerular endotheliosis. The data indicate that pregnancy can exacerbate renal disease and allow for early diagnosis. Fluorescence angiography revealed changes in patients in whom the optic fundi were normal. Tissues of glomerulonephritis stained by immune fluorescence against immunoglobulins and on occasion against human fibrinogen. Primary endotheliosis and nephrosclerosis stained against fibrinogen only. There was no pattern of laboratory data to make the differential diagnosis between primary endotheliosis and various forms of renal disease. Fibrinogen breakdown products were inconsistently increased in contrast to fibrin monomer formation, which was increased regardless of the underlying morphology. It is our feeling that renal biopsy with subsequent pathologic classification is the only technique we have at present which provides relevant information on the effect of renal disease on pregnancy and vice versa.

Biopsy↗
PubMed1976

[Misdiagnosis of "chalazion" (author's transl)].

The diagnosis of the often occurring "chalazion" usually puts no problems in diagnostic and therapeutical view. It must be considered, however, that already small particularities of the clinical findings point to other i.e. benign or even malignant processes. An analysis of a number of cases from 1969 to 1975 of the University Eye Clinic Münster showed in 21 out of 89 histologically examined tissue specimen another diagnosis. In 8 patients a malignant degeneration of tissue was histologically stated. The authors describe some cases, where during a longer period of time the malignant character of the disease was not diagnosed due to the misdiagnosed "chalazion".

Aged↗
PubMed1976

[Non-pigmented extrabulbar sarcomas of the eye-region (author's transl)].

The authors report on 30 cases with non-pigmented extrabulbar sarcomas of the eye-region which occurred in our clinic within the period of 1955 till 1975. The primary sarcomas of the orbit predominate with 11 cases over the secondary involvement with 9 cases. More seldom (5 cases) is the involvement of the lids and the epibulbar space. The various groups of lymphosarcoma predominate with 16 cases over the spindle-cell sarcoma with 6 cases. The age distribution shows that these tumors prefer the first three decades and the fifth and the following decennia. The prognosis is bad for the conservation of the eye as well as for the preservation of life. With reference to the localisation the distribution at the time of the beginning of the therapy as well as the histological findings an intensive therapy (operation, radiation, chemo-therapy) has to be accomplished.

Adolescent↗