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Biomedical subjects

H P Spängler

Publications and source records attributed to H P Spängler.

At least 19 recordsLinked to original sources
PubMed1981

[Closed intramedullary nailing of femur shaft fractures - experiences in 245 cases (author's transl)].

A follow-up study is given of 245 femoral shaft fractures, treated 1961-1975 with closed reduction and intramedullary nailing. 141 patients were examined personally 19-5 years after operation. The results were excellent in 75,9%, fair in 20,6%, and poor in 3,5%. Deep infections occurred in 2,4%. The number of patients was also subdivided in regard to indication, concomitant injuries, postoperative fatalities, pathologic fractures etc.

Adult↗
PubMed1977

[The technic of fibrin glue in cancellous bone transplants (author's transl)].

The paper deals with the clinical experience in the use of a biological adhesive system in conjunction with bone transplants to close large bone defects. The gluing technique has been exactly described, 11 patients with a follow-up between 9 and 21 months are being presented. The application of this system which consists of highly concentrated native fibronogen, thrombin, and clotting factor XIII results in an acceleration of homogenous incorporation of the implants. No deterioration of wound healing occurred. The advantages of this method are: exact local hemostasis, adhesive strength, and plasticity.

Adult↗
PubMed1977

[The action of high-concentrated fibria on bone healing (author's transl)].

The influence of a biological tissue glue--based on fibrinogen clotting--on bone healing has been investigated in animal experiments. Standardized cortical defects in the tibiae of rabbits were closed with a plug of homologous or heterologous fibrin. The course of restoration has been studied using histological techniques, x-ray examinations and isotopes (Ci 99 TC). Heterologous fibrin delays bone formation, due to a local immune response. Homologous fibrin on the other hand cubances and accelerates sprouting of capillary vessels and connective tissue cells which results in rapid new formation of bone.

Animals↗
PubMed1977

[Qualitative analysis of the binding of fibrin in organic tissue (author's transl)].

The binding energy (EB) of oxygen, sulphur and nitrogen was determined in highly concentrated fibrin, collagen, liver parenchyma and muscle tissue using photoelectron spectrometry. Fibrin was mixed with the collagen, liver or muscle homogenisate, with or without substitution of clotting factor XIII or additional inhibiton of fibrinolysis and the EB was determined again. Changes in the binding energy arise from an alteration in chemical binding. The present investigation showed that fibrin builds up new linkages in liver parenchyma and in collagen using nitrogen bonds and, additionally via a sulphur bond. After addition of fibrin stabilizing factor a new chemical link appeared between fibrin and collagen again through a nitrogen bond and, additionally via a sulphur bond. The inhibition of fibrinolysis produced a new oxygen linkage in all the examined substances (fibrin-tissue).

Binding Sites↗
PubMed1977

[Experiences with a biological adhesive system (fibrin) in the dressing of kidney parenchymal wounds (animal experiment and 1st clinical experiences)].

We report on investigations describing the use of a biological adhesive system for tissue adhesion and local haemostasis. This system consists of highly concentrated native fibrinogen and thrombin. Clotting factor XIII is admitted for reinforcement of the fibrin network. In experimental partial kidney resection this system was used with excellent results. This experience led to successful application of this method in 15 patients who underwent partial nephrectomy for various diseases.

Animals↗
PubMed1976

[Homologous articular cartilage transplantation in animal experiments. Preliminary studies on sheep (author's transl)].

Homologous articular cartilage without subchondral bone instead of the usual osteochondral grafts was transplanted in sheep. The transplants were fixed to the host by a biological tissue adhesive based on fibrinogen clotting. Light- and electronmicroscopic studies showed viable transplants up to 7 months and a stable bony union with the host through endochondral bone formation. A additional external fixation of the joint after transplantation or the use of a conventional cyanoacrylate tissue adhesive failed to achieve positive results. The relations of these preliminary findings for restorative techniques of articular cartilage defects are discussed.

Animals↗
PubMed1976

[Tissue adhesion and local haemostasis using fibrinogen, thrombin and clotting factor xiii. (experimental investigations--clinical experience) (author's transl)].

A report is given on experimental investigations and clinical experience in the use of a biological adhesive system. This system consists of highly-concentrated native fibrinogen, thrombin and clotting factor XIII. Experimental tissue adhesion was successfully performed in numerous experiments and with various organs. Local haemostasis was obtained even in cases when other methods failed by sealing off bleeding surfaces with a fibrin layer. The satisfactory results obtained in these experimental investigations were confirmed by the excellent outcome of a clinical trial. Fibrin represents a biological system which is completely absorbable, contrary to the commonly-used synthetic adhesives. Further advantages are its highly adhesive properties, elasticity of consistency and good tissue compatibility.

Animals↗
PubMed1975

[Heterologous fibrinogen for tissue adhesion. immunological and histological investigations (author's transl)].

The immunological reactions of heterologous fibrin were investigated in a sensitive experimental system. In 10 rabbits autologous full-thickness skin grafts were glued with bovine fibrinogen cryoprecipitate. 5 of these animals had been immunized against this adhesive before transplantation. In a control group the graft was fixed with homologous fibrinogen cryoprecipitate. Examination of the sera of the animals for antibodies against fibrinogen was performed before immunization, 1 day prior to and 14 days after skin grafting. 14 days after skin adhesion all grafted areas were examined by histological methods. In the group without preoperative immunization antibodies were found against fibrinogen. The skin graft healed in this series in the same manner as in the sham group. In the series with preoperative immunization the glued skin graft was discharged early and the healing procedure of the defect was retarded.

Animals↗