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Biomedical subjects

H P Wit

Publications and source records attributed to H P Wit.

At least 19 recordsLinked to original sources

On the relation between the dimensions and resonance characteristics of the vocal tract: a study with MRI.

The relation between the spatial configuration of the vocal tract as determined by magnetic resonance imaging (MRI) and the acoustical signal produced was investigated. A male subject carried out a set of phonatory tasks, comprising the utterance of the sustained vowels /i/ and /a/, each in a single articulation, and the vowel /epsilon/ with his larynx positioned variously on a vertical axis. Two- and three-dimensional measurements of the vocal tract were performed. The results of these measurements were used to calculate resonance frequencies, according to predictions from acoustical theory. Finally, calculated frequencies were compared with actually measured resonance frequencies in the audio signal. We found a strong relation between the acoustical signal produced and the spatial configuration for the first resonance frequencies of the articulations of the vowel /epsilon/, and first two resonance frequencies of the vowels /a/ and /i/. The capability to determine accurately vocal tract dimensions is a major advantage of this imaging technique.

Humans

Mechanical heart valve prostheses: sound level and related complaints.

In a randomised study, we investigated the sound production of mechanical heart valve prostheses and the complaints related to this sound. The CarboMedics, Björk-Shiley monostrut and StJude Medical prostheses were compared. A-weighted levels of the pulse-like sound produced by the prosthesis were measured in 25 patients after aortic valve replacement. Additionally, 141 patients, 117 after aortic valve replacement, 20 after mitral valve replacement and 4 after double valve replacement were interviewed. The average sound pulse pressure levels were 46.0 +/- 2.9 dB(A) in the Carbomedics group, 55.4 +/- 1.2 dB(A) in the Björk-Shiley monostrut group and 44.1 +/- 4.4 dB(A) in the StJude Medical group, measured at a distance of 1 cm from the chest. The Björk-Shiley monostrut was louder than the other two prostheses (p less than 0.0005). Twenty (14.2%) of all patients had complaints related to the valve sound such as sleeping disturbances, irritation, nervousness or fear. Significantly more patients with a Björk-Shiley monostrut could hear their valve or had complaints when compared to the other two prostheses. Younger patients and patients with a mitral valve prosthesis could hear their valve more often than older patients or patients after aortic valve replacement. We conclude that sound characteristics and related complaints differ considerably among heart valve prostheses.

Aged

Perception of audio-frequency vibrations by profoundly deaf subjects after fenestration of the vestibular system.

A survey is given of the literature on the sensitivity of the vestibular system to audio-frequency sound and vibration in animals. It is also shown that responses to such stimuli can be evoked in man. On the basis of these results it was decided to perform a fenestration of the horizontal semicircular canal in three profoundly deaf volunteers, with normal sensitivity of the vestibular system. The first results are promising: the threshold for audio-frequency vibration in the operated ears improved markedly. Furthermore, the subjects reported perception of environmental sounds using a bone conductor hearing aid.

Adult

Are spontaneous otoacoustic emissions generated by self-sustained cochlear oscillators?

Theoretical analyses supporting the assumption that spontaneous otoacoustic emissions (SOAEs) can be described as self-sustained oscillations (requiring a power source) are reviewed and extended. Spectral and statistical properties of spontaneous otoacoustic emissions are examined and shown to be consistent with this assumption. Several alternative models of spontaneous emissions (noise-driven saturating memoryless nonlinearity, noise-driven nonlinear-stiffness oscillator) are examined. Although some of these models are able to produce the types of statistical distributions of amplitude and displacement similar to those observed in the experimental data, this similarity is destroyed upon narrow-band filtering.

Animals

Temperature effects on auditory nerve fiber response in the American bullfrog.

Single fiber recordings were made from auditory nerve fibers of the American bullfrog (Rana catesbeiana). As temperature was raised: (1) Best frequencies of fibers from the amphibian papilla (N = 15) increased. Below 600 Hz best frequency changes up to 0.06 oct/degrees C were found; above 600 Hz changes were less than 0.03 oct/degrees C. In the basilar papilla (N = 4) no significant increase of best frequency was found. (2) Spike rates in response to fixed-RMS-amplitude stimuli increased considerably: Q10 of spike rate ranged from 5 to 10. (3) Spontaneous activity, found in basilar papilla fibers, increased with average Q10 = 1.6 (+/- 0.3). (4) A conspicuous change of tuning quality factor Q10 dB was only observed in two fibers, that were taken to low temperatures (less than 16 degrees C). (5) the nearly linear frequency vs. phase relation in amphibian papilla shifts to higher frequency (along with shift of best frequency), while its average slope remains nearly unchanged.

Action Potentials

Synchronization of spontaneous otoacoustic emissions to a 2f1-f2 distortion product.

Synchronization of spontaneous otoacoustic emissions to a cubic distortion frequency fs = 2f1-f2 has been studied. Stimulus, consisting of two primary tones at frequency f1 and f2, could easily be filtered out of the microphone signal. This enabled us to monitor emission phase with respect to synchronization frequency fs, by recording zero-crossing moments of the microphone signal. When primaries were sufficiently loud (typically 30 dB SPL), phase fluctuated around a constant value: The emission was constantly synchronized to fs. Lowering primary levels (to typically 20 dB SPL) resulted in 2 pi-phase jumps at random moments: The emission occasionally slipped out of synchronization, trying to maintain its own natural frequency f0. This behavior can be described as synchronization of an oscillator (frequency f0) to a sinusoidal force (frequency fs) in the presence of noise.

Auditory Threshold

Amplitude and frequency fluctuations of spontaneous otoacoustic emissions.

Amplitude and frequency fluctuations of spontaneous otoacoustic emissions have been studied. Spontaneous otoacoustic emissions were recorded from eight human ears and two frog ears (Rana esculenta). Record length typically was 80 s. For a recorded emission signal, the amplitude signal A(t) (average A0) and time intervals T(ti) between successive positive-going zero crossings (i counts zero crossings) were determined. Emission amplitude and period both showed small fluctuations: delta Arms/A0 ranged from 0.7 X 10(-2) to 6.3 X 10(-2) for human emissions and was 24 X 10(-2) for both frog emissions; delta Trms ranged from 1.4 to 6.9 X 10(-7) s for human emission and was 50.0 and 55.0 X 10(-7) s for the two frog emissions. There was a positive correlation between delta Arms/A0 and delta Trms as determined for different emissions (R = 0.9). Spectra of A(t) and T(ti) revealed that amplitude and period were slowly fluctuating functions: cutoff frequency delta f delta A of the amplitude spectrum ranged from 3 to 18 Hz; delta f delta T ranged from 7 to 32 Hz. Results have been compared to amplitude and frequency fluctuations of a second-order oscillator, that interacts with a noise source. It has been concluded that an oscillator with linear stiffness (for example a Van der Pol oscillator) driven by white Gaussian noise, cannot account for all experimental results. Other possible oscillators (e.g., nonlinear stiffness) and noise sources (e.g., narrow-band noise), that may account for the observed phenomena, are discussed.

Animals

Vibro-acoustic stimulation of the human fetus: effect on behavioural state organization.

Vibro-acoustic stimulation of the human fetus in being increasingly performed both antenatally and during labour, to differentiate between poor and good fetal health in cases of flat or otherwise suspect fetal heart rate patterns. In a controlled study we investigated the effect of the electronic artificial larynx (EAL) on fetal behavioural state organization. In 10 healthy women with normal pregnancies of 38-40 weeks of gestation, recordings of fetal heart rate, body movements and eye movements, with a duration of 120-210 min, were carried out during two consecutive days. In each fetus, 3-4 episodes of state 1F and consecutive state 2F were studied, one of which served as a control observation. EAL stimulation during state 1F was associated with excessive fetal movements and with a state change in 7 out of 9 observations (four times into 2F; three times into 4F). Stimulation during state 2F was associated with a change into 4F in four of the nine observations. On days with EAL stimulation the fetuses spent more time in state 4F or in an episode not classifiable (because of an atypical FHR pattern with tachycardia and small accelerations) than control fetuses (21% vs. 3% of time). Disorganized states or periods of state 4F sometimes lasted for more than 1 h following the stimulation. It is concluded that stimulation with the EAL induces excessive fetal movements, a prolonged tachycardia, non-physiological state changes and a disorganisation and change in the distribution of fetal behavioural states. Until more is known regarding the safety and risks of vibro-acoustic stimulation, it should not be used in a routine clinical setting.

Acoustic Stimulation

DC injection alters spontaneous otoacoustic emission frequency in the frog.

A permanent wire electrode was implanted in the inner ear of the green frog (Rana esculenta). Through this electrode direct current was delivered to the inner ear fluid of the frog, during recording of a spontaneous otoacoustic emission (SOAE). Both SOAE frequency and amplitude turned out to depend on DC level and polarity. Possible explanations for the observed phenomena are given, based on a dissipative limit-cycle oscillator model for SOAE generation, and the assumption that SOAE frequency depends on hair cell ion channel inductance.

Animals

Spontaneous otoacoustic emissions in the European edible frog (Rana esculenta): spectral details and temperature dependence.

Spontaneous otoacoustic emissions were recorded in 41 ears of 29 European edible frogs (Rana esculenta). Emission frequencies ranged from 450 to 1350 Hz. The distribution of frequencies shows two distinct populations: one above and one below 1 kHz. With one exception, a maximum number of two emissions were recorded per ear, each in a different population. An amplitude distribution of a frog emission was sampled, from which it was concluded that the emission is generated by an active oscillator. The spectral width of an emission ranged from 1 to 200 Hz (average 38 Hz). There was negative correlation between sound pressure level of an emission and spectral width. In 4 frogs the dependence of emission power and frequency on temperature was investigated. An emission could be 'switched on and off' within a few degrees centigrade. At temperatures below the switching interval no emission was recorded; for higher temperatures emission power showed no dependence on temperature. Frequency increased with temperature (Q10 = 1.1 to 1.3). This yields a mismatch with temperature dependence of best frequencies of auditory fibers. The consequences of this mismatch are discussed.

Animals

Vestibular microphonic potentials in pigeons.

Electrical responses to acoustic stimuli were measured by placing thin wire electrodes in the vestibular system of a pigeon model. Responses were measured after extirpation of the cochlea and the application of tetrodotoxin to the perilymphatic space. Responses seen were comparable to those of known cochlear microphonic potentials. These findings indicate that acoustic stimuli can evoke microphonic potentials in the vestibular system of the pigeon. We also found that vibrational amplitudes of less than 1 nm were sufficient to evoke a vestibular microphonic potential.

Acoustic Stimulation

Contrast enhancement in frequency spectra of cochlear microphonic responses to complex stimuli.

Cochlear microphonic responses were measured in pigeons and guinea pigs during stimulation with complex sounds. The acoustical stimuli had many component frequency spectra with a more or less undulating envelope. Enhancement of the peak-and-valley structure of the envelope occurred at high stimuli levels, especially if all frequency components in the stimulus had equal (cosine) phase. The observed effects could very well be modelled with a simple passive electronic network, as well as with an analytical expression that describes saturation of the cochlear microphonic at high stimulus levels.

Acoustic Stimulation

Diurnal cycle for spontaneous oto-acoustic emission frequency.

Spontaneous oto-acoustic emission frequency was measured in two subjects at different times on the same day. A statistically significant frequency decrease during the morning hours was observed for both subjects. Possible mechanisms (ear canal pressure, body temperature, androgen level) for this decrease are discussed.

Adult