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Biomedical subjects

H Pambakian

Publications and source records attributed to H Pambakian.

23 records · Page 2Linked to original sources

Astrocytic differentiation in medulloblastoma.

A case of cerebellar medulloblastoma with transitional features towards malignant fibrillary astrocytoma is described. In the cerebellum the tumour is characterised by extensive subpial infiltration with cells of undifferentiated type, and the astrocytic component could only be identified by a positive glial fibrillary acidic protein reaction. In the brainstem the character of the growth transforms to that of diffuse astrocytoma. This demonstrates the potential for differentiation existing in a "primitive" neuroepithelial neoplasm.

Astrocytes↗

Angiosarcoma of pericardium. Problems in diagnosis and management.

The clinical histories of two patients with angiosarcoma of the pericardium are described. Both were previously well young men who presented with cardiac tamponade caused by haemorrhagic pericardial effusions. If a pericardiectomy is undertaken for diagnosis, wide excision of the pericardium is recommended. This will provide a large specimen for histological examination and may prevent subsequent development of constriction.

Adult↗

Breast involvement in Wegener's granulomatosis.

Two cases of Wegener's granulomatosis are described in which the early and predominating lesions were found in the breast. The histological features of breast necrosis with granulomatous inflammation and widespread vasculitis in the breast in the absence of any demonstrable pathogens enabled a presumptive diagnosis to be made in one case before the development of the more characteristic clinical features in the respiratory system.

Adult↗