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H Paulsen

Publications and source records attributed to H Paulsen.

123 records · Page 7Linked to original sources
PubMedDate not supplied

From imino sugars to cancer glycoproteins.

This review summarizes fifty years of carbohydrate chemistry, from studies of reaction mechanisms and development of synthetic methods to the design of specific compounds for investigations of cancer glycoproteins. Through these years of intensive research, many carbohydrate derivatives were shown to be biologically relevant, for example the fragments of bacterial polysaccharides and imino sugars that were potent inhibitors of glycosidases. Oligosaccharides and O- glycopeptides with GalNAc-Ser/Thr linkages were essential for studies of cancer immunology and the specificities and inhibition of cancer glycosyltransferases. Thus carbohydrate chemistry has provided the basis for our knowledge of the biochemistry and immunology of cancer cell glycoproteins.

Animals↗
PubMedDate not supplied

[Protein composition of human sperm from oligozoo-, teratozoo-, asthenozoo- and azoospermia].

The amino acid analysis of seminalplasma and spermatozoa shows for the different andrological diagnoses that the predominant amino acids were aspartic--and glutamic acid, serine, glycine and lysine. Analytical data indicate that there were differences between plasma and spermatozoa for a lot of amino acids. No differences in the protein composition of the ejaculates were found between the various groups of andrological diagnoses.

Adult↗