A Contribution to the Study of Geotaxis in the Higher Animals.
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Journal Article↗
Biomedical subjects
H Perkins
Publications and source records attributed to H Perkins.
Identification of HIV-infected transfusion recipients: the utility of crossreferencing previous donor records with AIDS case reports.
An expanded "look-back" program has been developed, in which patients who may have been exposed to HIV through blood transfusion were identified via three triggers: the blood that they received was donated by persons who 1) have subsequently been reported to local health departments as meeting the diagnostic criteria for AIDS, 2) have donated since the introduction of anti-HIV screening and tested positive, or 3) have been found to be infected during investigation of reported transfusion-associated HIV infections. In comparing triggers, cross-referencing the list of patients reported to have AIDS (AIDS case list) proved to be the most efficient approach for identifying HIV-infected donors and transfusion recipients. Of the 7973 AIDS patients reported in eight Northern California counties as of December 1988, 316 (4.0%) were determined to have donated at Irwin Memorial Blood Centers between 1977 and 1985. Despite the logarithmic increase in reported cases of AIDS in the San Francisco Bay area over the last 5 years, the rate of detection of previous donors from AIDS case lists remained between 3.3 and 5.4 percent. These persons accounted for 69 percent of the identified infected donors, and their identification led to notification of 60 percent of potentially exposed recipients and 51 percent of known infected recipients. The crossreferencing of AIDS case listings with blood bank records was equally efficient for regions with low and high AIDS prevalence. National adoption of AIDS case list crossreferencing is recommended as an effective means of identifying previously unidentified infected recipients in an effort to limit the secondary spread of HIV infection.
Acquired Immunodeficiency Syndrome↗
Transfusion reactions: the changing priorities.
Over the last dozen years the relative frequencies of specific transfusion reactions have markedly altered, in general for the better. Although AIDS remains the Public's primary concern, the risk of AIDS from a transfusion is extremely low at this point. Hepatitis remains the most common infectious complication of blood transfusion, but only 1 in 6,000 units now carry a risk, whereas in the early 1980's the risk is believed to have been close to 10% per patient. Transmission of HTLV-I/II has also been markedly reduced by tests of donor sera. In contrast, cytomegalovirus has become of increased importance in view of the large number of patients immunosuppressed for transplantation and cancer therapy; bacterial growth in blood components appears to be increasingly common; and Chagas disease is likely to become a serious transfusion problem in this country. More widespread use of filters which remove three logs or more of white blood cells from components should play a major role in reducing transfusion reactions further.
Bacterial Infections↗