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H Philipp

Publications and source records attributed to H Philipp.

16 recordsLinked to original sources
PubMed2003

Investigation on the efficacy of meloxicam in sows with mastitis-metritis-agalactia syndrome.

The efficacy of meloxicam in the treatment of sows with mastitis-metritis-agalactia syndrome was investigated in comparison with flunixin. Basic therapy comprised administration of an antibiotic and oxytocin. A total of 200 sows and litters were examined in a double-blind clinical study with observations up to 8 days after the first treatment. The primary parameter, the clinical index score on day 2, consisting of rectal temperature, feed intake, general demeanour, respiratory rate, vaginal discharge, degree of inflammation of mammary glands, milk flow and nursing behaviour, revealed a significant (P < or = 0.05) non-inferiority of meloxicam in comparison with flunixin implying equal efficacy of both drugs. No significant differences were noted in the distribution of clinical efficacy scores within both groups at each day of examination. The differences in litter weight and daily weight gain per piglet were not significant between the two test groups. The mortality rates until day 8 of the study were without significant difference between groups. In piglets of diseased litters, however, the mortality rate was 50% lower in the meloxicam group in comparison with the reference group, this difference reaching statistical significance (P < or = 0.05).

Animals↗
PubMed1998

[Treatment of acute respiratory tract diseases in cattle with Bisolvon in combination with either enrofloxacin, cefquinome, ceftiofur or florfenicol].

The purpose of the present clinical studies was to determine the clinical efficacy of a combined parenteral and oral treatment with Bisolvon in combination with antibiotics in bovines suffering from acute respiratory disease. To this end four trials were conducted in respiratory diseased bovines; a total of 619 animals were evaluated. The animals were randomly assigned to one of two treatment groups within each study and were treated either with enrofloxacin, cefquinome, ceftiofur or florfenicol. The Bisolvon group was additionally treated with Bisolvon over 5 consecutive days. Daily clinical examinations were carried out over a period of 6 days. The clinical respiratory score, the primary parameter, representing a summation of the scoring points for the parameters respiratory rate, nasal discharge, spontaneous coughing, lung sounds and grade of dyspnoea and the clinical index score, which additionally included the general parameters fever, demeanour and feed intake, were significantly lower in the Bisolvon groups compared to the controls at all examinations after initiation of therapy in all trials with the exception of day 2 in one study. Lower values correspond to a less severe clinical condition. This consistent result as well as the evaluation of the single parameters are indicative of an acceleration of the recovery of the animals additionally treated with Bisolvon.

Acute Disease↗
PubMed1979

[Treatment of experimental immune complex nephritis with indomethacin].

Functional, histological and immune-histological examination were performed in altogether 64 Wistar-rats, in order to control the effect of a therapy with 2 mg/kg per body weight indomethazine lasting 2 months at the model of an experimental immune complex nephritis. In 44 rats after presensibilisation an immune complex nephritis was performed by intraperitoneal injections with human serum albumin which were repeated three times a week. 24 glomerulonephritis animals and other 20 animals without glomerulonephritis were daily administered indomethazin through a tube probe, the remaining 20 animals with glomerulonephritis served as untreated control groups. The excretion function of the kidney was tested before the beginning of the experiment, 2 weeks after the beginning of the therapy and the regular serum injections, respectively, and before the end of the experiment by determination of the biological half-life period of 131J-hippuran. In every case one day before this the proteinuria during 24 hours was determined. At the end of the experiment the kidneys were examined histologically and immune-histologically. The results showed that indomethazin does not lead to a clear influence on the proteinuria in the immune complex nephritis of the rat. The excretion of 131J-hippuran was significantly restricted, whereas the histological and immune-histological preparations in the animals with foreign serum injections showed clear changes of the glomeruli in the sense of an early stage of the immune complex nephritis, however, they did not show any essential influence by indomethazin. That is, indomethazin had altogether no favourable effect on the immune complex nephritis of the rat.

Animals↗
PubMed1977

[T-rosette and rosette inhibition test with antilymphocyte globulin following kidney transplantation].

263 examinations with the rosette-test with sheep erythrocytes and the rosette inhibition test with antilymphocyte globulin in 42 normal persons and 56 patients after transplantation of a kidney showed in 10 patients a significnat decrease of the rosette-forming T-lymphocytes in the peripheral blood under conditions of rejection. On the other hand the number of rosettes significantly increased in 4 patients. The valency of the rosette inhibition test for the rejection diagnostics is restricted by technical difficulties and wrong positive results (11%). The results are discussed on the basis of the receptor synthesis rates for sheep erythrocytes and of the electric superficial potentials of the T-lymphocytes and in relation to the HLA-A/B/C/D-system.

Antilymphocyte Serum↗
PubMed1976

[Immunopathogenesis of glomerulonephritis].

After an introductory description of some morphological points of view the author enters into the mechanisms of the immunopathogenetic lesion in different forms of glomerulonephritis. Hereby Goodpasture's syndrome, the acute post-streptococcal nephritis, the membranoproliferative glomerulonephritis, the sclerosing forms and the so-called glomerulonephritis with minimal changes are particularly taken into consideration. It is tried to describe the clinical course and the pathomorphological changes.

Animals↗
PubMed1975

[Cellular immunity to donor antigens after kidney transplants in humans].

Decisive for controlling renal transplantation is the knowledge of the immunological reactions. The cellular immuno-mechanisms, released via sensibilization by donor HL-A antigens, are specially important for acute rejection. To predict a crisis of rejection and to initiate increased immuno-suppressive measures it is important to know the degree of cellular immunologic response. The sensibilization was demonstrated in the experiments by means of the MEM test, using graft antigens isolated from spleen or kidney of the donor. In all patients an increasing sensibilization against donor antigen could be proved. The velocity of this sensibilization seems of value for predicting the duration of the graft's survival.

Electrophoresis↗