Biomedical subjects

H Pickford

Publications and source records attributed to H Pickford.

2 recordsLinked to original sources

PubMed1989

The potential for homeostatic regulation of the X region proteins of the human T cell leukemia virus type I.

The human T cell leukemia/lymphoma virus type I (HTLV-I) encodes two regulatory proteins, a 42 kDa trans-activator protein (p42tax) and a 27 kDa protein (p27rex), required for virus capsid protein synthesis. The experiments described here show that the p27rex protein negatively regulates the expression of the p42tax protein by suppressing the accumulation of the spliced messenger RNA from which the p42tax and p27rex proteins are made. It is proposed that such an interplay between the two regulatory genes results in a homeostatic system that may regulate the rate of viral replication as well as the growth of HTLV-I transformed cells.

Genes, Viral↗

PubMed1989

HTLV-I p27rex regulates gag and env protein expression.

The experiments reported here show that the p27 product of the rex gene that is encoded by the 3' end of the human T cell leukemia virus type I (HTLV-I) is required for expression of the virion capsid and envelope proteins. The regulation of virion protein expression occurs via posttranscriptional regulation of viral mRNA. In some contexts, regulation of the virion proteins is achieved by p27rex-dependent accumulation of unspliced or singly spliced mRNAs that specify capsid or envelope proteins. In other contexts, the envelope protein production is dependent upon p27rex even in the presence of accumulation of envelope-specific mRNA. The consequences of p27 regulation for HTLV-I replication are discussed.

Gene Expression Regulation, Viral↗