Biomedical subjects

H Pierron

Publications and source records attributed to H Pierron.

At least 19 recordsLinked to original sources

PubMed1995

[Precocious puberty and hypothalamic hamartoma: treatment with triptorelin during eight years].

BACKGROUND: Hypothalamic hamartoma, a rare cause of true sexual precocity, may develop slowly so that its diagnosis may be late. CASE REPORT: A 7 1/2-month-old girl was admitted because she suffered from development of physical pubertal changes. Laboratory tests were consistent with premature activation of the hypothalamic-pituitary axis. Initial neuroradiological investigation failed to find any cause. The patient was given medroxyprogesterone that resulted in regression of secondary sexual characteristics but growth rates and skeletal maturity remained accelerated. For that reason, the patient was given triptorexine, LH-RH analogue, 18 months later that resulted in a deceleration of puberty growth rate and skeletal maturity. MRI performed at the age of 9 years showed a small hypothalamic hamartoma and the LH-RH analogue was stopped at the age of 10 years. CONCLUSION: MRI is now the best technique for investigating the hypothalamo-hypophyseal area.

Dose-Response Relationship, Drug↗

PubMed1992

[Transient hyperglycemia and screening of diabetes. Illustration of diagnostic difficulties in prediabetic state, based on 2 cases].

The authors report two cases of prediabetic state (preclinical diabetes and transitory diabetes) for which the only positive predictive marker was the intravenous glucose tolerance test. The actual possibilities of prediction of insulin-dependent diabetes and the specificity and reliability of the different predictive markers are discussed.

Adolescent↗

PubMed1990

[Yersinia infection and hemoglobin disorder. Apropos of 4 cases].

The authors report 4 cases of Yersinia enterocolitica (Ye) infection in patients with hemoglobin disorders (3 beta thalassemia major, 1 sickle cell anemia). Patients with hemoglobin disorders are particularly vulnerable to Ye infection. Predisposing factors consist mainly of iron overload and deferoxamine therapy; superinfection with HIV may be an additional factor. The diagnosis is performed by identifying patients at risk and by bacteriologic tests (blood and stool cultures, antibody titers). Therapy includes discontinuation of deferoxamine and initiation of an adequate antibiotic therapy.

Anemia, Sickle Cell↗

PubMed1987