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Biomedical subjects

H Podhaisky

Publications and source records attributed to H Podhaisky.

At least 37 records · Page 2Linked to original sources

[Venous capacity and drainage volumes of arm veins].

On 29 test persons after clinical angiological and cw-Doppler-sonographic exclusion of an obstruction of the deep veins and an arterial occlusive disease on the upper extremities the capacity of the veins and the drainage volume were determined by means of the venous-occlusion plethysmography. The angiological measuring places Compactus 540 and Periquant 3800, respectively, of the firm Gutmann (group 1) and the 2-channel occlusion plethysmography of the former nationally owned measuring device factory Ballenstedt (VEB Messgerätewerk Ballenstedt) (group 2) were at our disposal. Apart from the obsolute values of the capacity of the veins and of drainage volume on account of the large interindividual dispersions the quotients were determined in the comparison of sides. In the two groups the drainage volume showed significantly larger values on the right arm than on the left one. In group 2 the measuring of the capacity of the veins and the drainage volume resulted in essentially larger values than in group 1. In contrast to the absolute values the quotients of the measuring values did not show any significant differences between the two groups so that it seems that these are better suitable of the judgment of the venous obstruction behaviour.

Adult↗

[Blood fluidity in essential hypertension, arterial occlusive disease and diabetic angiopathies].

Microcirculatory disturbances are important complications in hypertension, arterial occlusive disease (PAVK) and diabetic angiopathies. The special haemorrheological diagnostics for the judgment of the terminal vascular bed tended to the comprehension of the haemorheological risk. Due to the increase of the aggregation of erythrocytes and viscosity of the plasma in peripheral arterial occlusive disease and diabetic angiopathies this risk proved to be distinctly increased, in diabetes mellitus without vascular complications and essential arterial hypertension it proved less distinctly increased. In hypertension the application of diuretic drugs should be done more critically and more controlled, in order to avoid conditions of hyperviscosity with their sequels for the microcirculation. The internal therapy in PAVK and diabetic angiopathies must include the amelioration of the disturbed blood fluidity.

Arterial Occlusive Diseases↗

[The effect of glycerol trinitrate on the arterial pressure of the fingers].

In 35 patients with healthy vessels, 52 patients with vasospasm and 42 patients with stenoses or obliteration of the finger arteries with the help of the Parks-ultrasound-Doppler device model 806-A and a finger cuff of the size of 3.5 X 5 cm the systolic pressure of the finger arteries was measured before and after the administration of glycerol trinitrate. Since in test persons with healthy vessels no significant differences of the radial and ulnar volar finger artery, of the single fingers of one hand or in the comparison of the sides of the two hands was found, a concentration could be done. The relative and absolute increase of the pressure of the finger artery under glycerol trinitrate was most conspicuous in patients with vasospasm. No essential changes, as we expected, occurred in patients with organic disturbances of the arterial blood supply. Under variation of the lower limits of the norm of the pressure of the finger arteries the high values of the sensitivity, specificity and efficiency which are characteristic for the ultrasound-Doppler pressure measurement, lying over 0.90 particularly after pharmacologic vasodilation.

Arterial Occlusive Diseases↗

[Diagnosis of angiologic function in unilateral leg edema following combined treatment of cervix cancer].

For the clarification of the genesis of a unilateral dropsy of the legs which had appeared in 16 women after operative and radiologic therapy of a carcinoma of the cervix apparative angiological functional investigations were carried out. A slightly diminished plethysmographic drainage volume in a Doppler-sonographically unhandicapped deep venous flow off corresponded to the clinical picture of the secondary lymphatic oedema. The findings were compared with the behaviour of the parameters in thrombosis of the iliofemoral vein and test persons with healthy vessels. Only in two cases a venous component in form of a stenosis of the pelvic veins and a postthrombotic syndrome, respectively, could be objectified. Since the methodology renders possible a differentiation of lymphatic oedema and phleboedema, it is suitable for non-invasive controls of the course and has practical significance in the after-care of female patients with carcinoma of the cervix.

Combined Modality Therapy↗

[Variability of the indices of vascular resistance in carotid Doppler sonography. Study of influencing factors in healthy vascular probands].

In 83 test persons with healthy vessels within the Doppler sonography the resistance indices of the internal carotid artery and the supratrochlear artery were established and in the various regressor combinations with the help of the multiple correlation influences of age, pulse rate, systolic blood pressure and diastolic blood pressure as well amplitude of blood pressure were tested. Thereby only the combination of systolic blood pressure and amplitude of blood pressure proved to be relevant. The confidence limits of the PWI of the right internal carotid artery and of the supratrochlear arteries of the two sides were established so that in findings with limit value it is easier to be stated whether the changes are only caused by circulation or they are reference to underlying stenoses. There were no significances as to the sides of the peripheral resistance indices.

Age Factors↗

[Doppler ultrasound parameters for peripheral arterial vascular diagnosis].

In order to control the valency of Doppler-sonographic parameters for the arterial vascular diagnostics, in patients with arterial obstructive disease apart from the measurement of the blood pressure characteristics of Doppler speed curves were analysed. Proximal obstacles of the vascular system of haemodynamic relevance led to the systolic decrease of pressure in the area of the extremities and to the monophasic configuration of curves with increased diastolic flow velocity and loss of the reflux component. Relations to the degree of severity of the ischaemia were found. The Doppler-sonographic comprehension of a changed local behavior of resistance and blood supply was valuable also for the differential diagnosis.

Arteriosclerosis↗

[Findings of pulse palpation and non-invasively measured blood pressure values of the posterior tibial artery in arterial occlusive disease].

In 37 test persons with healthy vessels and 103 patients with arterial obstructive disease the clinical findings of the pulse palpation were related to the results of the systolic Doppler pressure measurement in the region of the posterior tibial artery. The experience of the investigator, physical influences, local extravascular factors as well as parameters of the central haemodynamics proved to be significant. A palpation of the pulse was successful in peripheral systolic pressure values lying higher than 90 Torr, so that here a judgement of the function alone became possible with the help of the palpatory pressure measurement of the posterior tibial artery. Unfavourable local conditions, however, can be followed by negative tactile findings of the pulse also in higher pressure values.

Arterial Occlusive Diseases↗

[Results of hemodynamic functional studies in peripheral micro- and macroangiopathy].

In order to assess the functional haemodynamic effects of a peripheral micro- and macroangiopathy in 59 patients at rest and under ergometric load non-invasive measurements of blood pressure and blood flow were performed with the help of the Doppler sonography, the venous-occlusion plethysmography and the 133-xenon-clearance methodology. Type 1 diabetics with microangiopathy showed a restriction of the vasomotor reagibility and the width of regulation, they, however, did not show a decrease of the muscular working hyperaemia. The arteriosclerotic macroangiopathy led to a pathologic pressure and flow reaction on exertion. With the help of the Doppler sonography asymptomatic vascular changes could also be detected at the clinical stage I.

Adult↗

[Methodologic aspects and criteria for evaluating extracranial carotid Doppler sonography].

Doppler-sonographic and internal angiological findings of 57 patients with extracranial stenosis or obliteration of the internal carotid artery were evaluated. On the basis of the audio-signals and Doppler speed curves derived from the supratrochlear artery, the common and internal carotid arteries haemodynamically relevant extracranial obstructions of the vascular system could be objectified and judged with regard to their collateral compensation. Diagnostically valuable were the comparison of the sides and the additional calculation of the indices of the resistance. The Doppler sonography of the carotid artery should be used within the clarification of a cerebrovascular insufficiency and before every invasive diagnostics.

Aged↗

[Differential diagnosis of inflammation-induced arterial vascular diseases].

The clarification of non-arteriosclerotic inflammatory vascular diseases is based on angiological, angiographical, immunological and immunohistological methods and parameters. As causes of the arterial occlusive disease of younger patients are taken into consideration the obliterating endangiitis and Takayasu's aortoarteriitis. To the clinical manifestations of the giant cell arteriitis belong the temporal arteriitis and the rheumatic polymyalgia. Hypersensitivity and panangiitides are to be delimited from the group of the pathergic granulomatoses. The secondary Raynaud's syndrome on the basis of a digital arteriitis is of differential-diagnostic and prognostic importance in collagenoses and rheumatoid arthritis.

Arteritis↗

[Significance of the use of glycerol trinitrate in functional angiologic diagnosis].

On 95 patients functional rheographic investigations and pressure measurements of the arteries of the big toes were carried out before and after the administration of glycerol trinitrate. Using the nitrate-induced decrease of the tone of the vessels persons with healthy vessels could more certainly be differed from patients with organic arterial occlusive disease of the lower extremities stage I and IIa. Despite the administration of glycerol trinitrate the rheography, however, does not reach the extraordinarily high reliability of the ultrasound-Doppler-pressure measurement in the early diagnosis of the arterial occlusive disease.

Arterial Occlusive Diseases↗

[Effect of nitrates on the peripheral arterial vascular system].

Nitrates decrease the tonus of the smooth vascular musculature and cause a vasodilation also in the region of the peripheral arterial system. This was shown after sublingual administration of glycerol trinitrate in test persons with a healthy vessel and patients with arterial occlusive disease in stage II. A significant change of the poststenotic systolic pressure and the influence on the parameters of the rheographic volume pulse curve developed. The peripheral effects of nitrate are used in the angiological functional diagnostics. They are of importance for the medicamentous therapy of vasospastically and organically disturbances of the arterial blood supply.

Adult↗

[Pedal ergometry--an efficient method of angiologic functional diagnosis].

In 61 patients with peripheral arterial obstructive disease (stages I and II after Fontaine) oscillographic, haemodynamic and ergometric functional examinations were performed. The pedal-ergometric charge maximum correlated with haemodynamic parameters. Informations were obtained which transgressed the exclusive pressure and flow measurement, for which reason the pedal ergometry is particularly suitable for the judgement of the function and control of therapy in arterial obstructive disease.

Arterial Occlusive Diseases↗

[Hemorheologic studies for evaluating microcirculation in patients with peripheral arterial circulatory disorders and diabetes mellitus].

Haemorheological investigations in 73 male patients with chronic disturbances of the arterial blood supply of the lower extremities and 54 male non-insulin-requiring (type-II-) diabetics with and without micro- and macroangiopathy resulted in significant changes of the flow properties of the blood in contrast to 20 comparable clinically healthy males. In all groups of patients a clear increase of the aggregation of erythrocytes and the viscosity of plasma as well as a decrease of the deformability of erythrocytes were to be proved. The size of the deviations of all three parameters from the normal correlated with the degree of severity of the arterial obstructive disease and in diabetics with the occurrence of vascular complications (macroangiopathy, retinopathy) as well as with the situation of metabolism. The decreased fluidity of blood may lead to the development of further enlargement of disturbances of microcirculation. Therefore, haemorheological viewpoints should be included into the total diagnostic and therapeutic concept of the arterial obstructive disease and the diabetes mellitus.

Adult↗

[Effectiveness of angiologic study methods in stage-1 arterial occlusive disease].

277 patients at stage I after Fontaine were examined for the control of the capacity for clinical and noninvasive apparative investigation methods for the early diagnostics of the arterial occlusive disease. Taking into consideration the angiographic reference method, calculations of sensitivity, specifity and efficiency as well as multivariate statistical evaluation were carried out for the individual techniques. Haemodynamically relevant obstructions of the vascular system could most certainly be established by means of ultrasound-Doppler-pressure measurements (sensitivity = 96%). Also the bicycleergometry and the oscillography under stress were suitable for the early diagnostics. The results of the angiological functional examination underlie the indication for further diagnostics and control of therapy.

Angiography↗

[Differential diagnostic problems in secondary acral circulatory disorders].

The broadly subdivided symptomatology of disturbances of the secondary acral blood supply, in which Raynaud's syndrome with its variants occupies a preferred position, demands solid basic knowledge of the physician, since triggering function or supporting permanent disturbance belong to a great number of basic diseases or primary disturbing factors. Thus the practicing physician has to do with comprehensive differential-diagnostic considerations with the aim of the correct recognition of the primary basic disease or noxa for the purpose of consequent induction of therapy. Angiological basis examinations, simple functional tests, a fundamental general physical examination, X-ray pictures granted for necessary and ECG-records as well as chemical laboratory findings alleviate the finding of the diagnosis like an exactly got anamnesis. In this therapeutic management subspecialists have then certainly only for a smaller part the task of further diagnostic clarification and therapeutic advice.

Blood Vessels↗

[Clinical aspects and differential diagnosis of primary and secondary microangiopathies].

Diseases of the terminal vascular system are of particular diagnostic and differential-diagnostic importance in clinical angiology. While in the functional microangiopathies of the skin as a rule disturbances of the vasomotor function without an essential value of the disease are concerned, secondary organic changes of the wall of the vessel not infrequently determine the course and the prognosis of the basic disease (rheumatoid arthritis, collagenoses, hypertension and diabetes). Vasomotor trophic disturbances are observed also post-traumatically, post-operatively, after exposition to cold, in a lesion of the central nervous system and vertebra nerve irritations. For the allergic hyperergic vasculitides, which show an extraordinary polymorphism in the clinical picture in characteristic histological findings, an auto-immune pathogenesis is to be supposed. The chronic arterial hypertension leads to arteriolosclerosis and necrosis with adequate organic symptoms. In the diabetic microangiopathy we may demarcate functional pre-stages from irreversible structural changes of the vessels, in which case apart from the peripheral microangiopathy of the skin the retinopathy and nephropathy are to be classified as particularly important clinical manifestations.

Cyanosis↗