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Biomedical subjects

H Pogglitsch

Publications and source records attributed to H Pogglitsch.

At least 55 records · Page 3Linked to original sources
PubMed1980

[Virus hepatitis B in hemodialysis wards: ways of distribution and possibilities of their interruption (author's transl)].

An attempt was made to describe differentiated problems in connection with virus hepatitis B in hemodialysis wards in a form as brief and precise as possible and to present some suggestions as to the elimination of this insidious disease. A through consideration of the hepatitis question yielding to a well established and legally sanctioned prevention concept would not only be of great importance to hemodialysis patients and their family members and the dialyses personnel but it would also play a great role for the protection of the general population. Finally, a statement by Baruch Blumberg (Nobel Price winner in Medicine, 1976) should visualize the universal importance of the hepatitis question once more: "If we succeeded in bringing hepatitis B under control, this would bring about a reduction of the rate of chronic liver diseases and of primary liver carcinoma."

Austria↗
PubMed1980

[The natural history of dialysis encephalopathy (author's transl)].

18 data with etiopathogenetic relations to the dialysis encephalopathy, such as plasma aluminum levels, parameters of azotemia and parathyroid function, blood pressure, IQ, and EEG-findings, were compared between 5 patients suffering with encephalopathy and 54 dialysis-patients without neurological symptoms. The investigations, including statistical computations (variance analysis, multiple linear regression, multivariate analysis) elicited the following results: 1. All patients suffering from encephalopathy showed higher plasma aluminum concentrations (505 +/- 58 microgram/L : 228.9 +/- 213 microgram/L, p = greater than 0.01), higher serum calcium levels (2.48 +/- 0.15 mmol/L : 2.35 +/- 0.11 mmol/L, p = less than 0.001), higher rates of osteopathy and abnormal EEG's (5 of 5 : 7 in 41 patients). 2. Age, duration of dialysis treatment, quality of dialysis treatment, blood pressure, did not show any pathogenetic influence. 3. Hyperaluminemia was caused by the oral administration of aluminum hydroxide. After reduction of the daily dose from originally 6.18 +/- 3.24 gm to 1.52 +/- 0.45 gm, the plasma aluminum levels decreased to 54.05 +/- 34.59 microgram/L without any adverse effects on the serum phosphate levels. The results suggest that dialysis-patients need less AI-OH than is usually indicated. 4. Encephalopathy did not occur after normalisation of plasma aluminum levels. 5. With respect to the aluminum toxicity in dialysis-patients, dialysis encephalopathy should not be classified as a complication of multifactorial etiology. Only hyperparathyroidism seems to be an additional risk factor.

Adult↗
PubMed1980

[When is hemofiltration indicated, in the treatment of renal insufficiency? (author's transl)].

Most of the patients on RDT, tolerate hemofiltration better than hemodialysis because hemofiltration rarely causes hemodynamic complications, or symptoms of disequilibrium. In comparison with hemodialysis, hemofiltration is more extensive and it's performance more laborious. With regard to the advantages, hemofiltration should be preferred in patients with high degrees of acotemia who appear for the first treatment, in patients suffering from cardiac insufficiency or autonomic insufficiency, and furthermore in all dialysis patients suffering from therapeutic refractory hypertension, neuropathy, and in risked elderly patients with hypotension.

Blood↗
PubMed1979

[Continuous determination of the blood density during haemodialysis (author's transl)].

Application of the mechanical oscillator technique for measurement of blood density, in combination with a reference method for the determination of the absolute value of the blood volume, enables precise and continuous monitoring of fluid shifts during haemodialysis. The significant correlation between blood volume and density or plasma volume and density allows each variation in blood volume to be calculated from the blood density and the slope of the regression line for each individual patient. The possibility of taking continuous measurements and the high accuracy of the mechanical oscillator technique commends this method for the measurement of short-term and small fluid shifts.

Blood Pressure↗
PubMed1978

[Hypophyseal dysfunction and chronic hemodialysis].

65 chronic hemodialysed patients showed a mean elevation of serum prolactin up to 35.5 ng/ml and a mean HGH level of 4.2 ng/ml, whereas TSH was within normal range. The response of the prolactin secretion to TRH was poor in patients with a high basal prolactin level. Patients with amenorrhea showed significantly higher prolactin values than menstruating women. It is assumed, that chronic stress caused the elevation of prolactin and HGH.

Adolescent↗
PubMed1977

[Low molecule and middle molecule metabolites with haemodynamic activity in the ultrafiltrate from uraemic patients (author's transl)].

Substances causing blood pressure changes and myocardial damage in rats were first detected in the ultrafiltrate obtained from patients on long-term haemodialysis by means of size separation, high-voltage electrophoresis and thin-layer chromatography. Of the 100 to 140 fractions produced by Sephadex G 15 chromatography at least 3 raised the blood pressure when administered in doses of 2 to 10 mg/0.1 to 0.2 ml 0.9% NaCl, that is the high molecular fraction 18 to 23 and the low molecular fractions 71 to 72 and 73 to 74. The fractions 96 to 98 and 97 to 106 showed high toxicity. Less than 1 mg/0.1 to 0.2 ccm 0.9% NaCl produced cardiac arrest. The fractions 35 to 55, which originate from the middle molecules and are retained in regularly uraemia, contain substances which caused a reduction in blood pressure at low dosage and cardiotoxic effects at a dosage of more than 10 mg. Thin-layer chromatography indicates that the substances most probably consist of peptides whose structure contains the amino acids leucine, isoleucine, valine, glutamic acid, aspartic acid, alanine and cystine.

Humans↗
PubMed1977

[The relation between the density of blood and the arterial pressure in animal experiments and in patients during hemodialysis (author's transl)].

The density of arterial blood was measured continuously in animals and in human beings with an accuracy of 10(-5) g/ml by the application of the so-called mechanical oscillator technique. The density measuring device is inserted into an arterio-venous shunt. The continuous reading of the density of arterial blood allows to observe the effect of fluid shifts between the interstitial space and the plasma space. For example, lowering of the capillary pressure by the constriction of the precapillary resistance decreases the blood density by the inflow of interstitial fluid. Strong vasoconstriction apparently increases the capillary pressure and thus raises the blood density by the loss of plasma-ultrafiltrate. During hemodialysis the fluid loss into the dialysator tends to increase the blood density. However, the regulatory mechanisms of the circulation are able to keep the density of the blood at a constant value as long as possible. An increase of the density indicates a decrease of the blood volume. The new method thus allows a continuous control of the course of hemodialysis, and to avoid a critical decrease of the blood volume and of the blood pressure.

Animals↗