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Biomedical subjects

H Poppe

Publications and source records attributed to H Poppe.

At least 55 records · Page 3Linked to original sources
PubMed1986

[Animal experimental studies on the therapeutic action of 5-(4-pyridino)-3-amino-1,2-dihydro-pyridinone (Cordemcura, AWD 08-250) in acute cardiocirculatory failure caused by poisoning by beta receptor blockers].

The therapeutical procedure in case of acute cardio-circulatory failure due to intoxication by beta-blockers has gained great importance owing to suicidal and accidental poisonings with lethal outcome. The use of beta-adrenergic agonists is difficult because a not predeterminable overdosage has to be applied in consequence of the competitive inhibition of the beta-receptor. Cardiotonics with a non-adrenergic mechanism of action thus make expect a surer handling. A severe cardio-circulatory failure is provoked by talinolol in the anaesthetized dog. The therapeutical effect of 4 mg/kg Cordemcura, given i.v. is represented by comparing the parameters cardiac rate, dp/dtmax, filling pressure in the left ventricle, arterial pressure, cardiac output, total peripheral resistance, and PQ time with a control group. The results prove a sure therapeutical effect, which is compared with other cardiotonics. A clinical use is recommended. The aptitude of the intoxication by beta-receptor blokkers as a model for the cardiac insufficiency is discussed.

Adrenergic beta-Antagonists↗
PubMed1985

[Antiarrhythmic action of 3-carbethoxyamino-5-dimethylaminoacetyl-iminodibenzyl hydrochloride (Bonnecor, AWD 19-166, GS -15) on experimental arrhythmia induced by aconitin, ouabain, calcium chloride and barium chloride].

In comparison with detajmium, prajmalium, ajmaline, quinidine, lidocaine, disopyramide, propranolol, and Ethmozin the substance GS 015 is tested on the aconitin-induced arrhythmia of the rat, the auricular fibrillation by aconitin of the dog, the ventricular arrhythmia induced by ouabaine of the dog, the arrhythmia caused by calcium chloride of the rat, and the arrhythmia induced by barium chloride of the rabbit. The particular qualities of effect in the special forms of arrhythmia are discussed in connection with the study of the antiarrhythmic action in case of coronary occlusion, with the increase of the electric fibrillatory threshold, and with the electrophysiologic tests.

Aconitine↗
PubMed1985

[Circulatory action and adverse effects of 3-carbethoxyamino-5-dimethylamino-acetyl-iminodibenzyl hydrochloride (Bonnecor, AWD 19-166, GS 015) in the dog and cat].

The haemodynamic and cardiac effects of GS 015, a substance of the series of the novel 5-(dialkyl-aminoacyl)-3-carbalkoxyamino-10,11-dihydro-5H-dibenz-[b ,f]-azepines with very potent antifibrillatory and antiarrhythmic actions, are studied on anaesthetized dogs and cats by means of the catheter technique. The clinical symptoms and the therapeutic range were tested on conscious animals. On the strength of the present results it can be stated that GS 015, given at pharmacodynamically effective doses, does not cause any circulatory side effects. A negative inotropic effect appears only at increased doses. Like other antiarrhythmic drugs, GS 015 possesses a limited therapeutic range which should be taken into consideration particularly in case of cardiac insufficiency. But an application seems possible also in patients during the acute stage of myocardial infarction.

Anesthesia↗
PubMed1985

[Pharmacokinetics and pharmacodynamics of 3-carbethoxyamino-5-dimethylamino-acetyl-iminodibenzyl hydrochloride (Bonnecor, AWD 19-166, GS 015) in the dog].

The antiarrhythmic action of GS 015 was studied in proportion to its plasma concentrations ascertained in parallel, making use of the model of the two-step coronary ligature in the conscious dog. Blood levels of 1.0 microgram/ml (2 mg/kg i.v.) or of 0.8 microgram/ml (5 mg/kg orally) brought about a complete suppression of ectopic arrhythmias. The limit concentration for this effect is about 0.5 microgram/ml.

Animals↗
PubMed1985

[Antiarrhythmic effectiveness of 3-carbalkoxyamino-5-(omega-aminoacyl)-10,11-dihydro-5H-dibenz-[b,f]- azepines].

The derivatives of a novel structure series of dibenzazepines dispose of intense antiarrhythmic properties. The relations between structure and effect in comparison with the antiarrhythmically active derivatives of phenothiazine (Ethmozine) are discussed. When substituting the beta-aminopropionyl chain with cyclic residue by means of a dimethylaminoacyl chain there appears a marked antifibrillatory action besides of the intense antiarrhythmic one. The compound 17, the 3-carbethoxyamino-5-dimethylaminoacetyl-dibenzazepine, proved to be the most efficacious compound in the course of the basic screening on two models: action on the effective refractory period in the rabbit's atrium and aconitin-induced arrhythmia in the conscious rat. In comparison with Ethmozin, an antiarrhythmic agent of the phenothiazine type, 17 shows a somewhat lower efficacy in case of i.v. application, but a distinctly intenser one was stated after oral administration. A profound test on the models: two-step coronary ligature in the dog according to Harris and electrofibrillation in the cat's heart, revealed an equally intense antiarrhythmic action but a considerably intenser antifibrillatory one. Therefore the compound 17 (abbreviated designation in the USSR: GS 015 or in the GDR: AWD 19-166) was provided for a thorough pharmacological and toxcological study.

Animals↗
PubMed1984

Optimization of detectors for modern liquid chromatography.

The development of modern liquid chromatographic methods depends strongly on the development of suitable measuring systems for the separated compounds. This is the case as generally an on-line coupling of separation and detection is preferred because of ease of operation, reliability and more efficient data handling. Unfortunately, the best conditions for the separation are often not optimal from the detection point of view. Conflicts arise in various respects and compromises have to be made. Depending on the complexity, cost and performance of each, either the chromatographic separation, or the detection process, has to be adapted, the one to the other. A number of contemporary developments in the techniques of liquid chromatography tend to sharpen these conflicts. Further reduction in particle size, reduction of the column diameter, introduction of multicolumn operation and the exploration of open tubular liquid chromatography can be mentioned in this respect. From this point of view a broad discussion of the role of detection techniques in the development and performance of liquid chromatographic analytical procedures is given.

Journal Article↗
PubMed1983

[Pharmacology of 1-phenylaminoethylamino-3-(phenoxy)propanol derivatives with beta-adrenergic action].

In the framework of a screening test of new phenoxyalkanolamines the authors tested derivatives with the basic structure Ph1--NHCH2CH2NHCH2CH(OH)CH2--OPh2 for beta-adrenergic blocking activity and sympathicomimetic action on the spontaneously beating atrial preparation from the guinea-pig and on the circulation of the cat. Derivatives with the substituents 2,5-dimethyl, 2-nitro, 3-nitro, 2,6-dimethyl and 2-chloro at Ph1 produced in the atrial preparation a some 3- to 10fold stronger beta 1-adrenergic blockade than propranolol. In in vivo experiments on the cat, all of these compounds had a potent sympathicomimetic effect on the heart, so that they may be classified as specific beta-adrenergic antagonists. The addition of 4-nitro, 3-methyl and 4-ureido at Ph2 reduces the beta-adrenergic blockade and suppresses the sympathicomimetic action. 1-(3',4'-Dimethoxyphenylethylamino)-2-hydroxy-3-phenoxypropane and its derivates showed a similar behaviour as described by Hoefle [8]. 1-[beta-(3-Nitrophenylamino)ethylamino]-2-hydroxy-3-phenoxypropane hydrochloride exhibited a particularly strong and long-lasting sympathicomimetic effect. Studies on the dog revealed a specific beta 1-mimetic action; in the effective dose range of 10-30 micrograms/kg i.v., a positive inotropic effect prevailed, and the effect on heart rate was but small. No beta-adrenergic blockade or mimetic action on the peripheral vascular system was observed.

Adrenergic beta-Agonists↗
PubMed1982

Simple and fast solvent extraction system for selective and quantitative isolation of adrenaline, noradrenaline and dopamine from plasma and urine.

A very simple solvent extraction system for the selective and quantitative isolation of adrenaline, noradrenaline and dopamine from plasma and urine is described. The extraction system makes use of the complex formation, in alkaline medium, between diphenylborate and the diol group in the catecholamines in combination with ion-pair formation. The influence of various parameters on the distribution coefficient was investigated by analysis of the liquid phases by high-performance liquid chromatography with electro-chemical detection. From these results the optimal extraction conditions can be selected. With hexane + 1% n-octanol containing 0.25% (w/v) of tetraoctylammonium bromide as extraction solvent, the catecholamines can be quantitatively isolated from plasma and urine at pH 8.6 in the presence of 0.1% (w/v) of diphenylborate. For urine the recovery was 101.5 + 1.9% for adrenaline, 100.6 +/- 2.0% for noradrenaline and 99.9 +/- 1.5% for dopamine. For plasma the recoveries were, respectively, 101.8 +/- 3.3%, 100.5 +/- 2.6% and 92.9 +/- 3.5%. The recovery of dihydroxybenzylamine, included in the study as internal standard, was determined to be 96.3 +/- 1.6% for urine and 89.9 +/- 2.7% for plasma. The applicability of the developed extraction system as clean-up and concentration step for the analysis of catecholamines in plasma and urine by high-performance liquid chromatography with electrochemical detection is demonstrated.

1-Octanol↗
PubMed1982

An unusual case of adamantinoma of long bones.

Adamantinoma of the tibia is a rare bone lesion, in which it is impossible to predict the biological behaviour. A case of extremely late local recurrence and lung metastasis is presented. Additionally, the patient developed pneumothorax on the right side months before intrapulmonary metastasis could be detected by X ray. Finally 1 week before her death the young woman suffered from paraneoplastic severe hypercalcemia leading to hypercalcemic coma and pancreatitis.

Adolescent↗
PubMed1981

[Studies on the circulatory side-effects of 2-[3'-diethylaminopropyl-(1')-carbamoyl]-6,7-dimethoxy-1-thiaiso-chroman-1,1-di oxide ("16-252") (author's transl)].

In view of its application to human beings, the authors tested 3-[3'-diethylaminopropyl-(1')-carbamoyl]-6,7-dimethoxy-1-thiasiochroman-1,1-dio xide ("16-252"), which is a potential antidepressant by its basic neuropharmacological activities, for circulatory side-effects on the rat, the cat and the awake carotid-ligated dog and compared them with those of imipramine. "16-252" differs from imipramine in principle. Whereas imipramine exerts above all a sympathiocomimetic circulatory effect (characterized by tachycardia, increased cardiac output and increased arterial pressure), "16-252" induces bradycardia, a decrease in cardiac output and a reactive increase of the total peripheral resistance. The doses of "16-252" required to bring about more marked circulatory side-effects are about 3-fold higher than those of imipramine. Medium doses of "16-252" do not produce the cardiodepressant effects typical of imipramine and they do not potentiate the action of administered noradrenaline typical of tricyclic antidepressants. The results obtained are discussed from the aspects of cardiotoxic properties in case of long-term therapy.

Animals↗
PubMed1980

[The possibility of side effects during the application of roentgenologic contrast media by the method of the biphasic bolus/perfusor injection and the monophasic bolus injection (author's transl)].

In spite to lower the dose dependent side effects by the application of roentgenologic contrast media in the computed tomography a system of a biphasic injection per bolus and perfusor was installed and compared with that of the monophasic bolus injection. Special rules on the installation of the perfusor at CT should be observed.

Contrast Media↗
PubMed1980

[Informative potential of computer-aided tomography (CAT), as compared to bilateral pedal lymphangiography, for the detection of gynaecological tumours, with particular reference to carcinoma of the cervix (author's transl)].

Experience so far obtained from whole-body computer-aided tomography is likely to suggest that the dimensions of primary tumours in the parametrial, paravesical, and pararectal regions can be defined with high accuracy, provided tumour diameters in excess of 2 cm. CAT also was found to be superior to other conventional diagnostic methods, when it came to better assessment of correlations between the tumour and neighbouring organs. CAT also helped to identify lymphomas in the retroperitoneal region, for example, in the pelvic retroperitoneum, and in the mesenteric region, although the same lymphomas were not or rarely identifiable by means of bipedal prefacial lymphangiography. - However, computer-aided tomography cannot replace lymphangiography, when it comes to an assessment of alterations of intranodular structures. Nevertheless, being a non-invasive diagnostic method, CAT can be successfully used in conjunction with lymphangiography to gain more information on the actual extent of lymph node formation. Hence, it can contribute to more accurate "in vivo" grading. - The method, for its non-invasive nature, may be highly useful in after-care tumour attention. CAT provides quasi-anatomic cross sections of the patient's body and is, consequently, a good basis for high-accuracy planning of radiotherapy.

Aftercare↗