[Occurrence, pathogenesis and clinical symptoms of arm edema in breast carcinoma].
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Arm↗
Biomedical subjects
H Poppe
Publications and source records attributed to H Poppe.
[Heterosexual treatment of breast cancers. (Experience of the Chirurgische Chirurgischen und Radiologischen Universitätsklinik Göttlingen)].
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Age Factors↗
Effect of the particle size in capillary electrochromatography.
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Benzene Derivatives↗
[The relationship between the chemical structure and anti-arrhythmia action of a number of omega-aminoacyl-3-carbalcoxyaminodibenzazepines].
The antiarrhythmic activity of 20 derivatives of dibenzazepine (the effects on the maximal effective rabbit heart auricle contraction rate, aconitine-induced arrhythmia in rats under or without anesthesia) was studied. It was shown that the most active compounds are those with carbethoxyamine group in position 3 in combination with dimethylamino- or diethylamino-acetyl groups in position 5 of dibenzazepine ring. 5-dimethyl-aminoacetyl-10,11-dihydro-5H-dibenz b, f azepine (GS-015, bonnecor) was selected for the further detailed investigation.
Aconitine↗
[Pharmacological research on bonnecor and its metabolites].
The antiarrhythmic and local anesthetic effects of 4 metabolites (G 491, ABD 19-200, ABD 19-199, ABD 19-205) of a new antiarrhythmic drug bonnecor (GS-015) were studied on the models of arrhythmias induced by aconitine (rats), barium chloride (rabbits), electrical fibrillation (cats), ouabain (dogs) as well as surface anesthesia (rabbit cornea). The side effects on the cardiovascular system were investigated on anesthetized cats. As compared with the original compound (bonnecor) metabolites G 491 and ABD 19-200 on different test models exhibited the action which on the antiarrhythmic terms was 2-14 times less weak than that of bonnecor but the metabolites were less toxic. Metabolites ABD 19-199 and ABD 19-205 reach the degree of effectiveness of bonnecor but their toxicity is higher. It follows from the above that the beneficial effect of bonnecor is not achieved by its metabolites.
Animals↗
[The anti-arrhythmia properties of bonnecor metabolites].
The experiments on the model of aconitine-induced arrhythmia in anesthetized rats and awake dogs with cardiac rhythm disorders caused by the coronary artery occlusion showed that all four metabolites of bonnecor possessed the antiarrhythmic activity. Metabolite 4 proved to be the most active on both models of cardiac rhythm disorders.
Aconitine↗
[The relationship between the physicochemical and pharmacokinetic parameters and the anti-arrhythmia activity of bonnecor and its metabolites].
The antioxidant properties of a new antiarrhythmic drug bonnecor and its main metabolites were determined by using chemoluminescence. A significant correlation was revealed between the physicochemical properties, antiarrhythmic activity, pharmacokinetic parameters of bonnecor and its metabolites.
Animals↗