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Biomedical subjects

H Porst

Publications and source records attributed to H Porst.

At least 55 records · Page 3Linked to original sources
PubMed1985

Dynamic cavernosography: venous outflow studies of cavernous bodies.

Based on dynamic cavernosography studies in 15 patients, including 8 with simultaneous passive erection, we present more precise details of the venous drainage of the penis. The venous drainage is comprised of 3 different systems. The superficial dorsal vein drains mainly the penile skin and prepuce, and empties via the external pudendal veins into the femoral vein. The deep dorsal vein, located between the tunica albuginea and Buck's fascia, drains the glans and all 3 corpora. The venae profundae penis emerge from each crus of the corpora cavernosa and drain only the corpora themselves. Considerable individual differences were found regarding further drainage via the pelvic venous system, including the prostatovesical plexus and internal pudendal veins. Passive erection was tried in 11 patients and was successful immediately after cavernosography in 8. The flow rates to induce an erection averaged 111 ml. per minute (range 55 to 160 ml. per minute), while the rate to maintain the erection was 48 ml. per minute (range 12 to 90 ml. per minute).

Adolescent↗
PubMed1985

Congenital and acquired penile curvatures: diagnosis and outcome with the Nesbit procedure.

A surgical correction according to Nesbit [1] was performed in 9 patients with congenital penile curvature as well as in 5 patients with acquired penile curvature in the context of Peyronie's disease and in 1 case after an old penile fracture. Dynamic cavernosography with simultaneous passive erection and photographic documentation of the curvature in two planes served as basic preoperative diagnostic methods. Besides the recording of a local report, the postoperative results were evaluated by means of a detailed questionnaire in all patients. 8 patients in the group of congenital curvatures as well as 3 patients of the group with acquired penile curvatures were shown to be completely satisfied with the functional result of the surgical correction. With the knowledge of the result of the operation, 13 out of 14 patients would indeed agree to the operation if asked again. This experience indicates that treatment according to Nesbit is justified in the therapy of both congenital and acquired penile curvatures.

Adolescent↗
PubMed1985

[Morphology and pathogenesis of liver injury produced by dihydralazine , propranolol and ketophenylbutazone].

Morphologically identical liver damage may be caused by dihydralazine (Depressan, Nepresol) and propranolol (Obsidan, Dociton). Among 24 patients with clinical manifestations of drug-induced hepatitis associated with Depressan or Obsidan treatment, liver biopsies in 15 showed drug hepatitic changes with confluent necrosis. In five of these cases this finding was combined with cholangiolitis, in four there was a drug-induced hepatopathy resembling the picture of viral hepatitis. In 20 cases of Ketazon-induced liver damage the biopsy demonstrated toxic hepatosis with or without cholestasis, reactive hepatitis or cholangiolitis. A drug-related hepatitis with central lobular necrosis was observed in one patient with Ketazon-induced liver damage. In 28 patients a lymphocyte proliferation test was undertaken to confirm a causal relationship between the use of either Depressan, Obsidan or Ketazon and the morphologically demonstrated liver damage. The test was positive in 25 cases (18 with Depressan, 2 with Obsidan and 5 with Ketazon). In several uncertain cases, for example, exposure to both Depressan and Obsidan or to Ketazon and Rewodina, the morphologic picture could be attributed to a specific medication by the use of the lymphocyte proliferation test. The results of the lymphocyte proliferation test and the morphologic findings emphasize the role of cell-mediated immune reactions in the pathogenesis of liver damage from dihydralazine, propranolol, and ketophenylbutazone.

Chemical and Drug Induced Liver Injury↗
PubMed1985

[Liver lesions induced by dihydralazine and propranolol].

The antihypertensive drugs dihydralazine and propranolol can produce identical liver injuries which must be distinguished clinically and morphologically from acute viral hepatitis. In 19 cases selected from our biopsy file during the last two years, clinical and morphological findings suggested that the liver injury diagnosed by light microscopy had been caused by an adverse reaction to dihydralazine and/or propranolol. In order to establish a causal relation the lymphocyte proliferation test (LPT) was performed with dihydralazine in 11 cases. Positive results were observed in 9 cases, demonstrating an etiologic role for dihydralazine in liver injury in these cases. The dihydralazine and/or propranolol induced liver injury consisted mainly of drug-induced hepatitis with confluent (bridging) necrosis. Different findings were observed in three cases: In two of these drug-induced hepatitis with confluent necrosis was observed together with eosinophilic cholangio-cholangiolitis. In one other case the histologic changes corresponded to drug hepatitis resembling viral hepatitis. Each of the three cases showed conspicuous centrolobular cholestasis, a feature which is unusual in drug-induced hepatitis with confluent necrosis irrespective of serum bilirubin levels. In one third of our cases we found morphological features of hypersensitivity reactions in the liver biopsies. Considered together with the results of LPT these features emphasize the role of cell mediated immune reaction in the mechanism of liver injury caused by dihydralazine and/or propranolol.

Biopsy↗
PubMed1985

[The stability of pilocarpine hydrochloride in eyedrops].

This study investigate the kinetics of the degradation of pilocarpine in aqueous solutions within the therapeutically relevant pH-value range from 2.9 to 6.5. A linear system of first order equations for the kinetics of complex pilocarpine degradation can be derived from the concentration course of decomposed products determined by HPLC. The kinetic parameters calculated from the results of isothermic short-term tests permit the prediction of a five-year durability of non-buffered pilocarpine eye drops, if their pH-value is in the maximum stability range of less than or equal to 4. Comparison of non-stereoselective photometric results with the hplc results shows the inappropriateness of the results of conventional spectrophotometric analysis in the presence of epimeric decomposition products for the interpretation of kinetic reaction and, accordingly, for evaluating stability. Contrary to previous studies, the results indicate a reversibility of epimerization in temperature-stressed isopilocarpine solutions.

Chromatography, High Pressure Liquid↗
PubMed1985

[The structure of degradation products of neostigmine bromide].

In aqueous temperature-stressed solutions of neostigmine bromide besides the known product of hydrolysis additional degradation products were discovered, detected by TLC and HPLC. By means of spectroscopic studies (1H-NMR, IR, UV, MS) and elemental analysis the isolated decomposition products were identified as 3-hydroxyphenyltrimethylammonium bromide (2), 3-dimethylaminophenol (3), 3-dimethylaminophenyl-dimethylcarbamate (4), 3-methylaminophenyl-dimethylcarbamate (5), 3-aminophenyl-dimethylcarbamate (6) and 4 (resp. 6)-bromo-3-dimethylaminophenyl-dimethylcarbamate (7). The structures of 2-7 were confirmed by comparison with synthesized authentic compounds.

Chemical Phenomena↗
PubMed1985

[The kinetics of neostigmine degradation in aqueous solution].

The concentration course of the degradation products of aqueous temperature-stressed solutions of neostigmine bromide (1) shows, that 1 simultaneously is hydrolyzed to 3-hydroxyphenyltrimethylammonium bromide (2) and demethylated to 3-dimethylaminophenyldimethylcarbamate (4). The ester hydrolysis is the rate-determining predominant reaction and of pseudo first-order. Under temperature-stressed conditions only, the demethylation to 4 followed by consecutive reactions proceeds at a measurable rate. The kinetic parameters of the ester hydrolysis calculated from the results of isothermic short-term tests permit the prediction of a five-year stability of 2% neostigmine solutions in the therapeutically relevant pH-value range from 3 to 7. On the basis of the kinetic results the possible reaction mechanisms and the influence of selected components on the rate of the hydrolysis and demethylation are discussed.

Dealkylation↗
PubMed1984

[Arteriographic diagnosis of erectile impotence].

The complex interactions of psychological, neurological, hormonal and vascular aspects of erectile dysfunctions require a standardised multidisciplinary diagnostic evaluation. The recent establishment of new noninvasive and invasive investigative procedures has led to a fundamental change in the assessment of erectile dysfunctions. Selective angiography of the internal pudendal artery and its branches represents the crucial diagnostic step before treatment can start. Indication, technique and results of 26 bilaterally performed pudendal angiographies on impotent patients are described.

Adult↗
PubMed1984

Percutaneous sclerotherapy of varicoceles--an alternative to conventional surgical methods.

Between May 1981 and October 1982, 259 varicoceles were identified by phlebography. It was possible to occlude 217 with Varicocid using a percutaneous Seldinger catheterisation technique under local anaesthesia. This method is an alternative to standard surgical techniques and has several advantages. It is cheap, it can be carried out on an out-patient basis, it lacks the risks associated with general anaesthesia and there are few complications.

Adult↗
PubMed1984

[Penile revascularization surgery in vascular impotence].

The application of objective diagnostic methods to patients complaining of erectile dysfunctions has proved that 30 to 40% are based on pathologic changes of the penile vascular system. The most important diagnostic procedures (NPT, Doppler, BCR-latency time, dynamic cavernosography with simultaneous passive erection, penile angiography) are emphasized and possible pitfalls with reference to misinterpretation of the diagnostic findings are discussed. Technique and results of current revascularization procedures (epigastricopenile anastomosis, revascularization of cavernous and dorsal arteries using vein grafts, deep dorsal vein arterialization) are discussed and first own experiences with aforementioned techniques presented.

Angiography↗
PubMed1984

[Erection and ejaculation disorders following retroperitoneal lymphadenectomy in non-seminomatous testicular tumors].

From 38 patients, who had undergone retroperitoneal lymphadenectomy in the period between April 1980 and October 1983, reliable statements were obtained referring to pre- and postoperative erectile and ejaculatory abilities. The thoracolumbar outflow (Th12-L3) of the centers for emission and psychogenic erection is usually damaged in this procedure. About 12% of the radically lymph node dissected patients complained of permanent erectile disturbances; 85% of the radically lymph node dissected patients revealed ejaculatory disorders, 58% of them with a total loss of ejaculation. About 50% of them showed a considerable psychic involvement. In 12 patients a modified lymph node dissection procedure was performed with the intention to preserve ejaculatory capability. Nevertheless 6 (50%) of them revealed postoperative ejaculatory failure, 3 of them with a total loss of ejaculation. Thus our own experiences and a review of the literature indicate that this modified lymph node dissection often fails in its purpose and can not always be considered a valuable procedure for preservation of ejaculation. The administration of sympathomimetic drugs and/or imipramine is a promising approach in the treatment of ejaculatory failure.

Ejaculation↗
PubMed1983

[Virus hepatitis C as an immunologically and clinically defined form of non-A, non-B hepatitis. A contribution to the diagnosis, clinical aspects, paraclinical aspects, course, prognosis and prevention of this disease].

After the detection of a non-A/non-B-associated antigen/antibody system--identity with the system of Shirachi and co-workers--we analysed clinical and paraclinical data of 106 women after application of contaminated anti-D-immunoglobulin. Of 106 infected female patients 84 fell ill manifest, 22 cases showed typical prodromi of hepatitis. The incubation time could exactly be calculated with 55 days (+/- s = 11). Apart from the parenteral the non-parenteral possibility of transmission could be proved. Remarkable are 50% of chronic cases three years after infection. As favourable markers of prognosis juvenile age, appearance of prodromi and clinical symptoms as well as signs of cholestasis are to be mentioned.

Adult↗
PubMed1983

[Side effects, complications and contraindications for percutaneous sclerotherapy of the internal spermatic vein in the treatment of idiopathic varicocele].

The results of 230 retrograde phlebographies of the V. spermatica int., 165 percutaneous sclerotherapies and 60 follow-up phlebographies on subfertile patients are presented. In 24 patients (10%) complications occurred, yet in none of the cases clinical damage became evident. Percutaneous sclerotherapie is contraindicated, when selective probing of the V. spermatica int. is impossible or massive collaterals to other venous systems could lead to an uncontrolled spread of the sclerosing agent. Treatment of idiopathic varicocele in subfertile men by percutaneous sclerotherapy is a safe and effective method, which can be performed on an outpatient basis. In our opinion the so far used surgical treatment can be replaced by it as a method of choice.

Collateral Circulation↗
PubMed1983

[Immunohistologic findings in the liver, spleen, brain and skeletal muscles in fatal cholestatic viral hepatitis (following double infection with hepatitis B and non-A/non-B?)].

We report immunohistological findings in liver, spleen, brain, and skeletal muscle of a 23-year-old woman with hepatitis nonA/nonB caused by contaminated anti-D-globulin. She died in a liver coma. At autopsy, a chronic liver dystrophy with cirrhosis was diagnosed. The necrotic areas of the liver showed a collapse of the reticulin framework, newly formed collagen fibres, and diffuse inflammation with immunohistological evidence of IgG, CIq, C9, and fibrinogen. C4 and C9 could be localised in bile thrombi and in the cytoplasm of pseudotubular transformed hepatocytes. In addition, C9 was found in blood vessel walls. A local distribution of HBsAg was found in the cytoplasm and/or the periphery of liver cells. HBcAg could not be detected in any of 5 different regions of the liver. A serum with antibodies to acute phase antigen of nonA/nonB hepatitis stained the cytoplasm and nuclei of (mostly intact) liver cells focally and their cell membranes diffusely. Patchy deposits of IgA and IgM were demonstrated in liver, brain und spleen. Circulating antibodies to cell nuclei and smooth muscle reacted with the patient's own liver and brain but not with spleen and skeletal muscle.--It is suggested that the manifold immunohistological findings in this patient are an expression of the vain attempt of the organism to clear away antigenic material, probably induced by different hepatitis viruses.

Adult↗