Biomedical subjects
Publications and source records attributed to H Povoa.
TRH was studied in rats with chronic Chagas disease. It was found an increased secretion of TSH 60 minutes after intraperitoneal injection of the hypothalamic hormone. T3 and T4 were also decreased in basal conditions. This may indicate a primary hypothyroidism.
The glucose content of normal human semen amounts to 0.41 +/- 0.09 mmol/l. As there is a negative correlation between this sugar and sperm motility, it must have an important role on the metabolism of these cells. Cervical mucus is very rich in glucose and does not contain fructose. This confirms utilization of glucose by spermatozoa.
Xanthine oxidase activity was studied in patients with hyperlipoproteinemia type IV. A significant increase of this enzyme as compared with normals was found. Furthermore, a positive correlation between xanthine oxidase and triglycerides has been observed. This explains the hyperuricemia commonly found in hypertriglyceridemic patients of Type IV.
The lipoprotein lipase activity is somehow associated with atherosclerosis, and some publications report a protective effect of this enzyme against infiltration of lipids. In this publication, an atherogenic diet was associated with a decrease of this enzyme in aorta and blood plasma of rats. After administration of folic acid, a significant increase of the clearing factor activity was observed.
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Plasmalogens have been determined in blood plasma, arterial and myocardial tissue of rats intubated with an atherogenic diet (vitamin D2 + cholesterol). These lipids are significantly decreased in arterial tissue after the administration of these substances for 5 consecutive days. Folic acid involved in the synthesis of plasmalogens and a powerful inhibitor of xanthine oxidase, on the contrary, increases enormously the concentration of plasmalogens in arterial tissue even with an atherogenic diet.
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