PubMed Health⌕ Search

Biomedical subjects

H Pressler

Publications and source records attributed to H Pressler.

32 records · Page 2Linked to original sources
PubMed1986

Immunohistochemical demonstration of alpha-fetoprotein in testicular germ cell tumors.

Immunohistochemically AFP was demonstrated in testicular germ cell tumors using the PAP method after Sternberger. AFP immunoreactivity was found in the yolk sac components of combined germ cell tumors. But embryonal carcinomas showed positive immunoperoxidase reaction for AFP in the cytoplasm of single cells in the solid masses and in areas forming tubular patterns. Also embryoid bodies in a polyembryoma and in combined germ cell tumors showed an AFP reactivity. Furthermore in immature teratomas positive staining was seen in epithelial cells of primitive cysts, adenoid and gut-like structures of probably entodermal origin. The positively reacting structures of combined germ cell tumors could be interpreted as early stages of embryonal development. Thus the results support the theory of totipotency of cells of embryonal carcinoma.

Dysgerminoma↗
PubMed1985

[Morphological research on DMSO-perfused kidneys].

It is reported on the morphological investigations of kidneys which had been perfused with the cryoprotective dimethylsulfoxide (DMSO). Some of these kidneys were stored for 72 hours at -4.5 degrees C and then retransplanted. The light-microscopic and electron-optical findings show considerable changes of the cells of the proximal tubulus epithelium and the collecting tubules. These in most cases focal findings of different extension do not differ on principle from the results in preservation techniques without DMSO. The dilatation of the basal labyrinth of the tubulus cell as well as the fissuration and vacuolization in the cytoplasm give references to a passive transport of substance by the cell. The results of the DMSO-perfused and at -4.5 degrees C stored kidneys show that for a beginning of the function an optimal perfusion must be supposed. On the one hand a sufficient concentration of freezing defense remedies in the renal tissue is necessary, on the other hand an optimum removal of the DMSO in the reperfusion is necessary, in order to keep the osmotic load of the kidney as low as possible.

Animals↗
PubMed1983

[Germ cell tumors of testis: histological classification of 552 cases according to the WHO-nomenclature].

Using the WHO-nomenclature 552 germ cell tumors of testis were reclassified. The analysis revealed the following: germ cell tumors occur in early childhood at the age of 3 months to 3 years, in adult hood (26-35) the occurrence shows a peak, and in old aged men only some tumors are registered. No germ cell was found between 4 to 13 years. Our material comprised 245 seminomas (44.4%) and 307 non-seminomatous germ cell tumors (55.6%). In the group of tumors of one histologic type, 245 cases of seminomas represent the main part. The following subgroups were recognized: typical seminomas--229 cases (93.5%), spermatocytic seminomas--9 cases (3.7%), and anaplastic seminomas--7 cases (2.8%). In 10 seminomas (4.1%() we have found syncytiothrophoblastic giant cells. In comparison to other investigations, the number of anaplastic seminomas is very low, but on the other hand the diagnosis Of this tumor is problematic, especially, the differential diagnosis of solid variants of embryonal carcinomas. The most common non-seminomatous tumor in this group is the embryonal carcinoma (16.8%). No polyembryoma and choriocarcinoma were observed, and only 2 yolk-sac-tumors occurred in infants. The occurrence of teratomas was also low, i.e. 15 cases of mature teratoma and 13 cases of immature teratoma. In the group of tumors of more than one histologic type, cases showing embryonal carcinoma and teratoma prevail (83 tumors). In addition to this combination other common tumors of this group (contained structures of seminomas (25 cases), yolk-sac-tumors (22 cases), an choriocarcinomas (19 cases) and embryonal carcinomas and yolk-sac-tumors (13 cases). Altogether, this group comprised 72.8% of the non-seminomatous tumors. Furthermore, the peculiarities of germ cell tumors of childhood are described. In this group the mature teratomas prevail. No seminoma could be registered in infancy. The distribution of our cases among the various types and the subgroups agreed in the main classes with that reported in literature but in special differentiations there are some discrepancies. The problem of classification of germ cell tumors is discussed.

Adolescent↗
PubMed1981

[Studies on Hypothalamic-Pituitary Thyroid regulation in Hemodialysis Patients (author's transl)].

During hemodialysis a continuous determination of free thyroid hormone and the basic TSH value was performed in 43 patients. a significant increase of free thyroxine and triodthyronine was found as well as a significant decrease of the TSH basal concentration in serum, which was already subnormal before hemodialysis. In 14 patients a TSH-TRH-test was performed before, during and after hemodialysis. A considerable reduction of the pituitary sensitivity to TRH administration during dialysis was found as compared with values before and after hemodialysis. Because of the increase of free hormone concentration, the reduction of TSH serum concentration and the decrease of pituitary sensitivity to TRH are considered to be a physiological reaction of the pituitary. On the other side a significant increase of the binding affinity of the T3 and T4 nuclear cell receptors correlated with concentration of heparin could be demonstrated. Because this modulation would induce an increasing occupation of the binding valences with thyroid hormone molecules, with a resulting decrease of the production of TSH, this process could also explain the results. Because ther is only a linear relation between the number of occupied nuclear binding sets and the TSH metabolism for T3, the physiological reaction of the pituitary is dependent on an intact conversion of T4 to T3 intracellular. A possible partly defect of this monodeiodination at hemodialysis patients could also explain the published different results concerning the basic concentration of TSH in the serum and the TSH-THR-test.

Humans↗
PubMed1980

[Thyroid function in patients with kidney insufficiency requiring hemodialysis (author's transl)].

In 43 hemodialysis patients different thyroid function parameters have been assessed. A characteristic combination of findings occurred in most cases. These were reduced values of total hormones in serum with normal free hormone levels. There was a reduced occupation of binding valences for TBG and a subnormal TSH. The TSH-TRH tests were normal. These changes in serum concentration can be explained at best by accepting a modulation of binding valences of transport proteins in the sense of reduced binding affinity. The various possible inducing mechanisms are discussed and the high sensitivity of binding valences to changes of the acid-alkaline equilibrium and temperature underlined. Both factors may play a role in uremic patients. Since not only in uremic patients but also in patients with various other diseases such changes in serum level can be demonstrated, there is a good chance that different mechanisms induce the same effect.

Humans↗
PubMed1980

[Determination of the concentration of thyroid hormones in dialysate and assessment of the loss of thyroid hormone during hemodialysis (author's transl)].

In order to determine the hormone concentration in a dialysate, the commercially available radioimmunoassay test of Dow-Lepetit for determination of free thyroid hormones in serum had to be modified. The results raised the suspicion that additional protein-bound hormone had passed the membrane. This could be demonstrated by the addition of Thiomersal. In 64 patients examined 1 and 5 hrs after the beginning of hemodialysis the mean total hormone concentration in the dialysate was 12.05 pg/ml for thyroxine and 5.47 pg/ml for triiodothyronine. The resulting loss of total hormone in hemodialysis patients, calculated for 1 week, amounted to 2.25 microgram triiodothyronine and 4.87 microgram thyroxine. The comparison with the physiologic renal elimination of thyroid hormone shows that the hormone elimination in hemodialysis patients is negligibly small. The quantitative determination of the protein concentration in the dialysate gave 384 ng/ml and was close to the limit of sensitivity of the method and consequently uncertain. It can be said, however, that the loss of protein is without clinical relevance.

Humans↗
PubMed1980

[Assessment of the loss of thyroid hormone during hemodialysis by administration of a hormone tracer in an in vitro experiment (author's transl)].

Several investigators have examined thyroid function in hemodialysis patients. Similar results were obtained: reduced total triiodothyronine and subnormal thyroxine values in serum. This raised the question whether a deficiency in hormones during hemodialysis could be responsible for these findings. The present studies were ade in an attempt to prove or disprove this assumption by determining hormone loss. The loss of thyroxine during hemodialysis was 1.1 microgram. This order of magnitude excludes a hormone deficit caused by dialysis. The assumption that an increased loss of hormone during hemodialysis is the cause of pathologic changes in the serum as compared with the period before dialysis can be considered as disproved.

Humans↗
PubMed1979

[Carcinoembryonic antigen (CEA) and CEA-like activities in ascites and pleura-effusions (author's transl)].

Carcinoembryonic antigen (CEA) was assayed in 18 samples of non-malignant and 21 samples of malignant effusions. In 95% of benign effusion CEA activity was found within normal limits and increased only in one case of Klebsiella pneumonia. In 57% of the 21 malignant effusions CEA levels were elevated and in 4 cases elevated titers were first indications of the malignancy of the effusion. In some cases remarkable differences between serum titer and effusion titer were found. Combined measurement of CEA activity in plasma and effusion increases diagnostic value.

Ascites↗
PubMed1978

[Congenital partial defect of the pericardium with herniation of the left atrial appendage (author's transl)].

Congenital partial pericardial defect with herniation of the left atrial appendage presents a rare anomaly. Clinical appearance of a 25-year-old man with this anomaly combined with adherance to the left lung hilus and the pericardial sac is described. He suffered from cardiac arrhythmias and dyspnea during exertion. The chest X-ray film at unremarkable physical examination and routine laboratory data within normal limits showed a prominent shadow of the left cardiac border, the cineangiocardiographic findings revealed that the prominence was due to a large left atrial appendage. Since strangulation of the left atrial appendage is a well-known and described potential hazard, thoracic surgery was performed without any complication.

Adult↗
PubMed1977

[Prophylactic gynecologic examinations in a stationary region].

We prophylactically examined female patients on the occasion of clinical treatment by other medical branches. Our gynaecological examinations were performed corresponding to a recommendation of the common decision of the SUP Central Committee, the GDR government and the TUF Central Board of Sept. 25th, 1973. From April 1th, 1974 to April 1th., 1975 2960 patients from 26 other clinics were screened. The frequency of histologically confirmed diseases of tumors due to registration (56 cases = 18,9(0/00) was higher than supposed compared with similiar screening programs. Under the cases were 5 carcinomas in situ, 3 microcarcinomas and 3 cervical carcinomas of stage Ib and higher. The share of discovery was 1,7 (0/00) for carcinomas in situ and 2 (0/00) for invasive cervical carcinomas. 28,6(0/00) of all women had a benign disease due to treatment or control. These examinations support, screening programs of a whole territory. The requisite expense is less than for similar programs on the outside of clinics.

Adult↗