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Biomedical subjects

H Preussler

Publications and source records attributed to H Preussler.

At least 19 recordsLinked to original sources
PubMed1993

Clinical and radiologic features, lung function and therapeutic results in pulmonary histiocytosis X.

Clinical appearance, radiologic findings, lung function and results of corticosteroid therapy were analyzed in 42 adult cases of biopsy-proven pulmonary histiocytosis X. Symptoms were present in only 64%. Using the ILO classification 1980, the evaluation of chest radiographs revealed all categories of profusion, size and shape of nodules. The characteristic 'ring figures', i.e. thin-walled cysts, in the parenchyma were detected in 78% of conventional tomographies (n = 27) and in all patients examined by CT (n = 5). In patients with early disease, lung function tests (n = 26) including body plethysmography, pulmonary diffusing capacity and ergospirometry revealed that parameters of gas exchange are most sensitive (TL,CO 84%, KCO 72%). Bronchial reactivity to carbachol was significantly higher than in controls (n = 12). Lung perfusion scintigram showed an abnormal, but uncharacteristic pattern in 81% (n = 26). During corticosteroid therapy, no progression was observed (n = 36). 85% of patients with radiographic evidence of progressive disease improved after administration of corticosteroids (n = 14).

Adolescent↗
PubMed1986

[Histologic changes in the epithelium of the respiratory mucosa of the lower turbinates following argon laser strip carbonization in vasomotor rhinitis].

The histological findings after argon-ion-laser-carbonization on the respiratory mucosa of the lower turbinates in vasomotor rhinitis are described directly after laser treatment and 6 years later. The laser surgical procedure without bleeding, the reduction of swelling of the lower turbinates, a slight diminishing of secretion, a significantly better nasal ventilation are demonstrated by the histological findings. The main characteristic histological findings are: a cuneiform laser lesion extending deep into the tissue to the venous plexus, four different typical tissue layers immediately after laser treatment, centrally the carbonization zone surrounded by a coagulation zone and next to this a honeycombed zone surrounded by a very small oedematous zone. Healing of the laser lesion is always complete. First of all, a squamous epithelium with subepithelial fibrosis and hypertrophy of the muscle cells in the venous plexus are seen. Half a year after laser carbonization metaplasia of the stratified squamous epithelium into pseudostratified cylindrical ciliated epithelium is seen. Occasionally, small islands of stratified squamous epithelium are visible.

Adolescent↗
PubMed1986

[Septumplasty. Histologic changes in resected and reimplanted autologous septal cartilage and bone following crush injury].

The histological findings of the crushed deviated septal cartilage and bone are described directly after reimplantation between the mucoperichondrium periostium in septoplasty, and after 11, 16, 24 and 26 months as well as after 6 and 6.5 years. Immediately after crushing, multiple fractures different in width and damage of single cartilage cells and bone cells are visible. The crushed reimplanted material shows partial absorption and partial regeneration especially near the fracture lines over a period of several years. Months and years after reimplantation, the following can be observed: vascularised connective tissue grows into the fractures, metaplastic bone production and a new growth of cartilage-like plates are visible at the crushed cartilage, primary and secondary bone production are visible at the crushed bone. Clinically, a stable plate of bone and cartilage is seen after septoplasty in the reimplantation zone. The importance of reimplantation of crushed material in septoplasty is emphasised.

Adult↗
PubMed1977

[Regional suppurative lymphadenitis after BCG vaccination (author's transl)].

In the first half of 1975 there occurred in the Federal Republic of Germany an unusual rise in the incidence of suppurative inguinal lymphadenitis after BCG vaccination of newborns, in immediate time relation with change of the vaccine by its manufacturers, Behringwerke. The attenuated daughter strain Göteborg had been replaced by the effective but also rather aggressive strain Copenhagen 1331. The complication rate was 1.5% in West Berlin. Clinical course, operative technique as well as microbiological and histomorphological features of these cases were analyzed in a joint study. Since it is likely that, after re-admission of the Copenhagen vaccine, such complications may again occur despite reduced micro-organism count, vaccination of newborns should in future be restricted to those at risk.

BCG Vaccine↗
PubMed1977

[Special diagnostic and therapeutic aspects of pulmonary histiocytosis X in twelve cases from 1969 to 1975 (author's transl)].

15 cases of histiocytosis X and 274 cases of histologically confirmed sarcoidosis were diagnosed during the investigation period from 1969 to 1975. Data of 12 adults with primary pulmonary histiocytosis X were evaluated in extenso. The necessary histological verification of diagnosis was only possible by open lung biopsy. Already in early stage small excavations were found by tomography in half of the cases. Eelvation of serum copper and of the index of leukocyte alkaline phosphatase was striking. In a single case antinuclear antibodies were proven. An intra patient comparison verifies corticosteroids suppressing the disease. On the occasion of a second lung biopsy in one case could be seen that after treatment no more histiocytosis-specific substrate was existing. Exacerbation and relapse during and after continuous long-term therapy were not observed. The features of histiocytosis X and sarcoidosis are set side by side in order to show differences and relations.

Adolescent↗
PubMed1976

[Light microscopic findings of cryosurgically treated tonsils following chronic tonsillitis (author's transl)].

The light microscopic findings of tonsillar tissues from nineteen patients (aged 13-51) with the clinical diagnosis of chronic tonsillitis are described at sequential intervals following cryosurgical treatment. The Cooper instrument was used, containing liquid nitrogen and capacity limited cryoprobes as well as probes of a flow system. Two consecutive freeze-thaw cycles were used during a single session in each patient, with freezing time varied from 30 seconds to three minutes. In addition to primary cryosurgical tissue changes such as hyperemia, edema, inflammation, necrosis, fibroplasia with capillary increase, collagenous fibrosis and reepithelialisation, the following could be found: 1. A different cryosensibility of the cells and fibers within the cryolesion: The tonsillar septae are much more resistant to cold than the lymphoid tissue. Of this latter tissue, the reticulin cells and the lymphoblasts are more sensitive to the cold changes than are the matured lymphocytes. In the epithelium the stratum basale is as sensitive to cold as the lymphoreticulum. The outer epithelial cells are more resistant to cold than the basal cells. 2. A quick proliferation in the periphery of the cryolesion is seen in the form of an acanthosis and papillomatosis which begins before slough of necrotic debris occurs. 3. Sharp demarcation and protracted sloughing of necrotic epithelium from the free tonsillar surface or crypts and lymphoid tissue can be seen. 4. Reepithelialization can first be seen following slough of the cryonecrosis twenty days following cryosurgery, after which total reepithelialization occurs.

Adolescent↗
PubMed1975

[The minimal freezing temperature for a necrosis of the epidermis and the influence of cryoprotective agents (author's transl)].

The sensitiveness to cold of the epidermis (cold threshold) is determined on the auricular skin of 24 rabbits, using freezing temperatures of -10, -15, -20, -25, -30, and -40 degrees C and a freezing time of 30 sec. The experiments are performed with and without application of cryoprotective agents (DMSO, glycerol and aethanol in a 10% solution) before cryosurgery. Only at -20 degrees C a necrosis of the epidermis is seen whereas after application of cryoprotective agents before freezing a necrosis of the epidermis first appears at -30 degrees C. Following these experiments clinically it might be possible to protect the epidermis in the periphery of the freezing area up to a certain degree with the use of cryoprotective agents, so that a topographically more concentrated epidermis-necrosis and therefore a limitation of the cryoeffect to the epidermis to a certain degree could be possible.

Animals↗
PubMed1975

[The cryoeffect on the growing bone (morphological findings on the kneejoints of rabbits as an example) (author's transl)].

The cryoeffect on growing long bones is studied. The kneejoints including the bordering surrounding epiphyseal disks of the femur, tibia and fibula of 35 young (4-6 weeks old) and 6 adult rabbits were frozen by dipping the knee joints totally or partially into liquid nitrogen (-196 degrees C). The freezing time varies 3-5 min. After different times of survival maximally up to 397 days the animals are sacrified. The length of the cryosurgical treated and untreated extremities are measured and the kneejoints, especially the epiphyseal disks, are studied lightmicroscopically. Totally or partially frozen joints show after a complete necrosis in the phase of regeneration and reparation an uncoordinated overgrowth of cartilage-and bone cells and a proliferation of connective tissue with deformation of the epiphysis. The above mentioned facts and the disturbance of growth in length in young animals is mainly caused by the irregular function of the epiphysical disks after being treated cryosurgically. Also the epiphysical disks being only partially treated cryosurgically show growth disturbances and deformities. Deducing from the animal experiments clinical cryosurgery, has to be applied with extreme caution in the surrounding area of growing bone in children so that the centers of growing bone are not be frozen. Treating bones of adult rabbits cryosurgically there are only time limited reversible morphological findings so that clinically cryosurgery can be used in the surroundings areas of adult bones, especially joints, without any remarkable morphological long term findings.

Age Factors↗