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H Pribylová

Publications and source records attributed to H Pribylová.

At least 19 recordsLinked to original sources
PubMed1996

Long-term prognosis of infants of diabetic mothers. Relationship between metabolic disorders in newborns and adult offspring.

The aim of our study was to find out whether the metabolic disorders in the newborns of insulin-dependent diabetic mothers (NDM) in the neonatal adaptation period could be associated with their condition in adulthood. We examined 148 children of diabetic mothers (CDM) aged 20.75 +/- 0.31 years (mean +/- SE); 11 were diabetic patients, while in the remaining 137 CDM, the oral glucose tolerance test (OGTT) was performed. CDM were compared with 31 matched control offspring of healthy mothers. Of the characteristic abnormalities occurring in NDM, the following were present in our study: macrosomia, hypoglycaemia, hyperlactacidaemia, hyperbilirubinaemia. In adulthood, the sum of the blood glucose and plasma insulin values during OGTT, body mass index (BMI) and blood pressure were determined. The observed abnormalities and the degree of their relevance in the neonatal period were not related to the sum of blood glucose and plasma insulin levels, BMI and blood pressure in adulthood, but the values of all these parameters in adulthood were significantly higher in CDM than in controls (P < 0.05-0.001).

Adult↗
PubMed1995

[Risk of diabetes mellitus, variations in glucose tolerance, insulin secretion and lipid parameters in offspring of diabetic mothers].

BACKGROUND: Children of diabetic mothers are a relatively new population group which started its existence due to revolutionary changes in the treatment of insulin-dependent diabetes during pregnancy. In the Institute for the Care of Mother and Child since the fifties comprehensive care of diabetic mothers was concentrated and thus it became possible to follow-up a relatively large group of their children to adult age. METHODS AND RESULTS: The authors investigated 176 children of diabetic mothers (CDM) aged 20.75 +/- 0.31 years. All mothers suffered from insulin-dependent diabetes mellitus (IDDM). In 7.95% CDM diabetes developed at the age of 11-23 years (IDDM in 4.54% and NIDDM in 3.41% of CDM). An impaired glucose tolerance was revealed in 6.25%. The mean blood sugar level during the oral glucose tolerance test was significantly higher than in a control group of 31 subjects of the same average age without a family-history of diabetes (p < 0.01). The ratio of insulinaemia to the blood sugar level was markedly higher not only when the glucose tolerance was impaired (p < 0.005) but also in CDM with a normal glucose tolerance (p < 0.025). The total cholesterol and triacylglycerol levels did not differ from the control group. In the group of DDM with an impaired glucose tolerance the non-esterified fatty acid levels were higher, as compared with controls (p < 0.05). CONCLUSIONS: The results of the described group of CDM which is one of the groups followed-up for the longest period reported in the literature indicate the risk of children of diabetic mothers and the necessity to follow-up and screen subclinical signs of the disease.

Adolescent↗
PubMed1994

[Complications in insulin-dependent diabetic mothers during pregnancy and the long-term prognosis for their children].

The authors investigated whether vascular complications of insulin-dependent diabetic pregnant women can influence on a long-term basis their children in adult life. In a group of 169 children of diabetic mothers (CDM) 12 developed diabetes during childhood and adolescence; in the remaining 157, age 20.75 +/- 0.31 (SE) the following tests were made: oral glucose tolerance test (OGTT), insulin level, parameters of the lipid metabolism, and blood pressure was assessed. CDM were divided into three groups: 1. CDM whose mothers had diabetic complications; according to White's classification of diabetes during pregnancy they belonged into class D and F (n = 10). 2. CDM whose mothers were classified with regard to diabetes during pregnancy as class B and C with subsequent toxaemia of pregnancy (n = 27), 3. CDM of mothers class B and C without toxaemia of pregnancy (n = 117). All investigated groups of CDM had significantly higher sums of blood sugar and insulin levels during the OGTT (P < 0.01), as compared with the control group (n = 31). In the first group of CDM the values were significantly higher than in the third group of CDM. As to cholesterol and triacylglycerol levels, the differences were not significant, the non-esterified fatty acid levels were higher in the second group than in controls (P < 0.05). In the first two groups also a higher systolic pressure was recorded than in controls (P < 0.01). Two children of the first group, two children of the second group and eight children of the third group of CDM developed diabetes.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1993

Urinary amylase isoenzymes and amylase polymorphism variants in families with diabetes mellitus type 1.

Insulin-dependent diabetes mellitus type 1 is an autoimmune disease of pancreatic beta-cells with a certain genetic predisposition that is not yet clear. In spite of the confirmed association of diabetes mellitus type 1 with several HLA haplotypes it is considered that other loci must be involved for total genetic susceptibility to the disease. The relationship of insulin deficiency and decreased pancreatic amylase activity suggests that insulin itself is a direct activator of amylase gene expression. Endocrine pancreatic function was monitored by the indirect non-invasive method of urinary pancreatic amylase activity determination (expressed in percentage of total amylase activity) in diabetic children, their parents, healthy sisters and brothers, and in a separate group of women with diabetes type 1 of over 20 years duration. The incidence of hereditary amylase polymorphism variants in these subjects was also ascertained. Decreased pancreatic amylase activity in urine (under 58%) was found to be a characteristic trait in diabetics, and a susceptibility trait in asymptomatic family members. Normal pancreatic amylase activity (66.7 +/- 5.4%) is rare in diabetic patients type 1, but may be seen as a favourable prognostic trait, representing resistance to diabetic complications. The results support the suggestion that hereditary predisposition to the disease is inherited from the father rather than the mother, and that heterozygous amylase polymorphism variants protect their carriers against diabetes mellitus type 1.

Adolescent↗
PubMed1993

[Development and interrelations between certain respiratory and biochemical parameters in normal neonates].

The authors investigated the development and interrelations of respiratory and biochemical parameters of normal neonates during the adaptation period from 15 minutes to the 7th day after delivery. They found that the correlations of oxygen consumption, carbon dioxide output, respiratory volume and minute ventilation are positive and independent on the time of assessment. These respiration parameters are independent on the glucose, lactate and pyruvate levels, on the respiratory quotient and pH and pCO2. The authors characterize the similarity of the trend of individual parameters and the variability of normal values.

Blood Glucose↗
PubMed1992

[Hypertrophy of neonates in diabetic mothers and their long-term prognosis].

Hundred and seventy five infants of diabetic mother born and followed up carefully in the Institute for the Care of Mother and Child were examined at a mean age of 20.75 +/- 4.08 years. The purpose of the investigation was to assess the relationship of hypertrophy of neonates of diabetic mothers to other deviations in neonates and their long-term prognosis. In neonates with a marked degree of hypertrophy the authors recorded significantly more frequently hypoglycaemia, early asphyctic syndrome, impaired respiration and neurological symptoms. Children born as hypertrophic developed equally frequently diabetes (8.7%) as children of diabetic mothers who did not develop hypertrophy (8.0%). Abnormal glucose tolerance was recorded in those with hypertrophy in 6.6%, in the group without hypertrophy in 5.0%. As compared with the offspring of healthy mothers, they suffered significantly more frequently from higher blood sugar levels and higher insulinaemia (sigma C ad sigma I) during the oGTT. The body weight expressed as BMI and systolic blood pressure were also higher than in the control group. None of the investigated indicators in adult age was associated with body weight and the degree of hypertrophy. The development of diabetes is determined more by genetic factors.

Adult↗
PubMed1989

Offspring of diabetic mothers in adulthood and their glucose tolerance.

A total of 150 offspring of diabetic mothers, born and followed up at the institute of Care for Mother and Child, were examined at a mean age of 20 years. A control group consisted of 34 age-matched subjects without a family history of diabetes. Diabetes mellitus was diagnosed in 7.3% (in (children of seven mothers) of the followed up offspring of female diabetics. While normal glucose tolerance was found in 82%, impaired glucose tolerance was present in 6.7% and borderline values in 4%. However, compared with control group levels, mean glycaemic values following glucose load were increased even in the offspring of diabetic mothers with normal glucose tolerance. Mean insulin levels were likewise increased, and were highest in the group of children with impaired glucose tolerance. Nineteen percent of the children on follow-up lost their mothers already during adolescence, at a mean age of 15 years, when their mothers were 41 years old. Thirty-seven percent of mothers were recipients of disability pensions due to diabetic complications. Children of diabetic mothers represent a group at high risk requiring follow-up also in adulthood.

Adult↗
PubMed1989

[Follow-up of the development of children up to the age of 8-12 years after prenatal glucose infusion].

Children whose mothers were given prenatally glucose infusions as therapy of foetal hypotrophy were examined at the age of 8-12 years. A group of 24 of these children were compared with a group of 29 controls born as hypotrophic without prenatal glucose infusions. All children were born after the 37th week of gestation. Complications in the neonatal period were more frequent in the control group; no relationship of the subsequent development and postnatal hypoglycaemia was found, a less favourable development was recorded in one third of the children with a history of polycythaemia. Between the two groups of children no differences in morbidity were found, however, neurological abnormalities and other complications were less frequent in children who had the infusion. The assumption that the development of children born hypotrophic can be favourably influenced by prenatal glucose infusions seems justified according to long-term results.

Child↗
PubMed1989

[Diabetes type in families with children of diabetic mothers].

Within the framework of a long-term investigation of children of diabetic mothers the authors investigated the family-history of diabetes and its types on the side of the mother and father. The incidence of diabetes was related to the state of glucose tolerance in 155 grown-up children of diabetic mothers (106 mothers with insulin dependent diabetes--IDDM; 17 mothers with non-insulin dependent diabetes--NIDDM). In the family-history of mothers with both types of diabetes NIDDM predominated. IDDM which developed by the age of 20 years was recorded only in siblings and in children of 5.9% and 4.7% mothers with IDDM. In families with diabetic children the mild form of IDDM was found in mothers and in children, once in a father. Abnormal glucose tolerance in children of mothers with IDDM was present in 7%, while the family-history of the fathers was negative, in 36% in case of concurrent NIDDM of the fathers and in 15.8% in children of mothers with NIDDM. The results confirmed the heterogeneity of diabetes. They indicated that when evaluating the risk of the offspring of diabetic mothers it is essential to take into account the family-history of fathers and to define the type of diabetes, as between the types certain hitherto not elucidated relations exist.

Adolescent↗