Biomedical subjects
Publications and source records attributed to H R Atta.
A 22 year old Caucasian girl living in Glasgow presented with eye disease due to Vitamin A deficiency. There was no evidence of liver disease or malabsorption and the vitamin deficiency was found to be due to her bizarre dietary habit.
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A 76-year-old Caucasian woman presented with a caruncle tumour, histologically diagnosed as mixed adenosquamous carcinoma. Complete excision was performed, but this necessitated removing parts of the lacrimal canaliculi. No local recurrence or distant metastasis was found after six months' follow-up, and spontaneous recanalisation of both canaliculi occurred. This tumour is believed to be a primary adenosquamous carcinoma of the caruncle and possibly the first reported case. Long term follow up is planned to detect late metastasis, but complete excision of the tumour and its favourable site should yield a good prognosis.
Forty six normal volunteers were randomly assigned in double-blind fashion to once daily orally administered nadolol 10, 20, 40, or 80 mg for five days. Significant and dose related intraocular pressure (IOP) reductions (range 20-40%) were demonstrated both at three hours and 24 hours post dosing (p less than 0.001, all dosages). The reductions in IOP were dose related (p less than 0.05). One subject (in the 10 mg group) failed to show a significant intraocular pressure reduction. Significant reductions in blood pressure and heart rate also were recorded at all dose levels (with the exception of diastolic pressure in the 10 mg group), though considerably less in degree than IOP reductions. Two subjects (20 mg and 80 mg groups) experienced known side effects of beta blocker therapy necessitating termination of the drug, and four others experienced mild side effects but had no difficulty completing the study. The results have prompted further investigation of the usefulness of low doses of oral nadolol as therapy in chronic simple glaucoma patients.
Ocular metastases from urinary tract carcinoma are extremely rare. Three previous cases of choroidal metastases from transitional cell carcinoma from the urinary bladder have been described, as have 2 cases of orbital metastases from bladder carcinoma. This is believed to be the first reported case of choroidal metastasis from transitional cell carcinoma of the renal pelvis in a 50-year-old female patient. The tumour, despite the absence of extension beyond the pelvic wall, showed disseminated metastases that proved resistant to chemotherapy. The fluorescein angiographic and ultrasonographic findings are described and the literature is briefly reviewed.
While most patients with Graves' ophthalmopathy have minor or largely cosmetic problems, severe ocular morbidity can occur and lead to blindness or eye loss. In this article the role of surgery in the management of Graves' ophthalmopathy is reviewed.