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Biomedical subjects

H R Müller

Publications and source records attributed to H R Müller.

At least 19 recordsLinked to original sources
PubMed1979

[Decompressive craniotomy in herpes simplex encephalitis].

Two patients with herpes simplex encephalitis (HSE) underwent decompressive craniotomy with brain biopsy. The indication for the procedure was in both cases computertomographic finding of a large, space-occupying process situated in the temple lobe with clinical picture involving febrile state, progressive hemiparesis, and subconsciousness. The patients were treated with standard doses of Ara A and methylprednisolone immediately after operation. In both cases, the improvement was very impressive. The massive neurological deficits -- in one case even including subtotal aphasia -- disappeared almost completely in the weeks following operation. 6 months later both patients underwent cranioplasty. These observations show that decompressive craniotomy with dilatation of the dura represents a decisive therapeutic approach in the case of HSE when the pressure of the brain cannot be brought under control by medical treatment. Computertomography proved to be of particular diagnostic value and assists in taking decisions for meaningful surgical treatment.

Adult↗
PubMed1979

[Effect of hypoxia on pulmonary gas exchange and hemodynamics].

To test the influence of hypoxia upon the pulmonary gaseous exchange and the hemodynamics of the pulmonary circulation 12 healthy test-persons at the age from 33 to 47 years (mean = 36.7 years) were submitted to a pulmonary and cardiocirculatory basis-investigation with determination of VK, VE, VO2, VCO2, Hb, PO2A/a, PCO2A/a, pH, BE, HR, ECG, PVd, PAp, SV, HZV, RL. These investigations were followed by stress examination by means of the bicycle-ergometry in four rectangular steps under conditions of normoxia from 95.5 to 97.3 kPa, x = 96.5 kPa (716 to 730 torr, mean = 723.6 torr) and of hypobarohypoxia in a low-pressure chambre at 66.5 kPa (500 torr) each of 6 min duration. Under the influence of hypoxia a PO2a-decrease in the sense of partial insufficiency could be already observed at rest under conditions of a decreased alveolar oxygen-partial-pressure. At this simultaneously increases the CO2-exhalation. At the same time was found a significant increase of the systolic peripheric and the diastolic pulmonary-arterial pressure. At the increasing step-by-step ergometric employment under conditions of the hypoxia stress were growing significance evidence of different reactions of the pulmonary and cardiocirculatory parameters occurred.

Adult↗
PubMed1979

[Absences from school in Basle primary pupils].

In the lower income group children of full-time working mothers have the lowest average of school absences, whereas in the higher income group they have the highest average. School absences of children in the lower income group increase markedly with increasing learning problems which might point out class differences of our schools.

Absenteeism↗
PubMed1979

Light microscopic stereological analysis of the normal human prostate and of benign prostatic hyperplasia.

Normal prostate glands from 6 men less than 30 years old and enucleated tissue of benign prostatic hyperplasia were analyzed by stereological methods. Studies on the relative volumetric amount of fibromuscular (stromal) and glandular areas of the gland reveal no statistically significant difference between the inner and outer parts of the normal prostate and between the inner part of the normal prostate and benign prostatic hyperplasia. However, in benign prostatic hyperplasia there is a significant increase in the volumetric amount of the fibromuscular tissue and a decrease in the glandular area compared to the outer part of the normal prostate and the whole normal prostate (sum of the inner and the outer parts). These stereological data are discussed with respect to the pathogenesis of benign prostatic hyperplasia.

Adult↗
PubMed1978

[Reliability of the ECG analyzer EAK-2 in screening tests].

In the last years the number of derivated electrocardiograms with several approaches to the problem has permanently increased. Therefore, the computer analysis seems to be obvious. The reliability of the analogo-digital-computer Express Analyzer Cardiograph EAC-2, Medexport Moscow, was for the employment for occupational medical examinations investigated on 252 experimental persons and compared with the independent manual analysis, which was carried out by two physicians. 80 per cent of the available ECGs were automatically correctly arranged into groups and all the inconspicuous electrocardiograms were sorted out, since it occurs on no account that an electrocardiogram which was recognized as pathological by means of manual analyses, was analysed as falsely normal by the computer EAC-2. Consequently, EAC-2 at low technical interference susceptibility may be very useful for the ECG-diagnosis by means of the computer during the screening investigations.

Arrhythmias, Cardiac↗
PubMed1978

[Thermographic thorax diagnostics].

Among several variants of devices the infra-red thermography has obtained a wide technical perfection allowing to measure the thermal energy emitted from the body surface without contact, quickly and dynamically, and to produce a picture for analysis. Since numerous functional and pathophysiological proceedings are connected with changes of temperature, the use of thermography for diagnosis of processes near the body surface may be recommended. Based on thermic observations in 63 patients and a control experiment in 15 persons, experiences with the thermography in the diagnosis of diseases, which are localized more profoundly in the thoracic cavity, were reported.

Adult↗
PubMed1978

[Migration and behavioral pecularities of nursery-school children in Basel].

The Basle Kindergarten Study is looking at the effects of migration on health and development. Local, social and cultural relationships are broken up through migration. We call this break of relationship "up-rooting". Deviant behaviour can be understood as indicator of disturbed psychosocial development. Two hypotheses are examined: 1. Signs of up-rooting are concentrated in migrant-families. 2. The children in these families show more deviant behaviour. Both hypotheses are not supported by our preliminary data.

Child Behavior Disorders↗
PubMed1977

[Study of sick behavior as a basis for the planning of health education].

A model of illness behaviour has to take into account different factors of the social milieu, of social learning and personality. Many research projects have been done to develop concepts explaining different aspects of illness behaviour. These concepts can serve as intervening variables in our model. This comprehensive model of illness behaviour is used for the planification of an epidemiologic study with school children. The results will serve as a base for planning comprehensive programs in health education.

Adult↗
PubMed1977

[Chiasmatic syndromes-diagnostic possibilities with computerized tomography (CT)].

The normal suprasellar subarachnoid space (so-called "suprasellar hexagon") and its content are fairly well demonstrated by CT. Abnormal appearance (obstruction, stenosis, asymmetry) of this space is always suspect of a suprasellar space occupying lesion. Enhancing (intravenous application of iodine containing contrast medium) helps to delineate the exact tumor extension. The point of origin--important for deciding on the nature of a lesion--is often difficult to determine. The CT-pattern itself is not specific for a certain kind of tumor. We have observed a typical chiasmatic syndrome with all meningiomas of the tuberculum sellae, with 75% of the chromophobe adenomas and with 50% of the craniopharyngiomas. Absence of this syndrome was due to high position of the tumor (craniopharyngiomas) or to parasellar extension of the lesion (chromophobe adenomas). Diagnosis of recurrent tumor is difficult; it must be based on the post-operative CT-examination. Chiasmatic syndromes not due to the pressure effect of a space occupying lesion (i.e. chiasmatic syndromes of vascular, toxic or degenerative origin) can not be assessed directly by CT.

Adenoma, Acidophil↗
PubMed1976

[Aspects of the risk-free use of micro-catheterization in 3342 examinations].

The microcatheterization for purpose of sounding of the right heart has proved itself in the prediagnostics of vitia cordis, for verification of the latent cor pulmonale, especially in combination with the bicycle ergometer load, and in the intensive medicine in the permanent measurement of the pressure of the pulmonary artery. The method gives the advantage of the frequent reproducibility and at the same time uncomplicated usability. In 3,342 microcatheter investigations only eight complications appeared (0.24% of the cases). Practical methodical references are given and possibilities of error in registering the pressure are indicated.

Cardiac Catheterization↗