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Biomedical subjects

H R Markar

Publications and source records attributed to H R Markar.

4 recordsLinked to original sources

Occurrence of schizotypal and borderline symptoms in parasuicide patients: comparison between subjective and objective indices.

Seventy-six patients were interviewed within a week of admission following a parasuicide episode. Axis II diagnosis on DSM-III was made for schizotypal, borderline, histrionic, and antisocial personality disorder. In addition patients completed a self-rating questionnaire, the Schizotypy Questionnaire of Claridge & Broks (1984), which assesses schizotypal and borderline personality traits. The objective and subjective indices of schizotypal and borderline symptoms correlated significantly but allocation of patients to a diagnosis missed several patients who nevertheless rated themselves as having a high frequency of these symptoms. There was an asymmetry of symptom pattern reminiscent of Foulds & Bedford's (1975) hierarchy model. The presence of schizotypal symptoms appeared to be higher in the hierarchy: they predicted borderline symptoms, but a high frequency of borderline symptoms did not necessarily predict schizotypy. We suggest that the occurrence of schizotypal symptoms should become a more explicit focus of clinical assessment and treatment of these patients, especially those who repeatedly harm themselves and we suggest ways in which cognitive therapies may be adapted to do this.

Adolescent

Solid versus liquid lithium--a pharmacokinetic study.

The pharmacokinetics of solid lithium (Priadel) were compared with liquid lithium citrate in nine manic depressive patients. The results show that whilst the 12-h steady-state levels are similar, there are significant differences in the degree and rate of absorption between the two preparations. The clinical implications of this are discussed further.

Adult

Money hidden and rediscovered in subsequent manic phases. A case of action dependent on mood state?

A manic-depressive patient hid 3000 pounds during one manic phase and subsequently, when his mood stabilised, could not remember where he had hidden it. He found the money during a subsequent manic phase a few months later. We suggest that this is not a clear case of state-dependent memory, since the patient at no point explicitly recollected where he had hidden the money. Instead we suggest that this represents state-dependent action. The links between this case and previous research on state-dependent memory are outlined.

Adult

Efficacy of lithium prophylaxis in clinical practice.

The efficacy of lithium prophylaxis in bipolar affective disorder in clinical practice was investigated. Comparison was made between 41 patients who were prescribed prophylactic lithium after two admissions in two years or three admissions in five years and a group of patients who did not receive lithium. The benefits conferred by the prescription of this drug were modest compared with the results from clinical trials.

Adult