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Biomedical subjects

H R Ochs

Publications and source records attributed to H R Ochs.

At least 127 records · Page 7Linked to original sources
PubMed1980

Single- and multiple-dose kinetics of intravenous digoxin.

Nine healthy men received 0.5, 1.0, and 1.5 mg digoxin intravenously in random sequence on occasions separated by at least 4 wk. Digoxin concentrations were measured in serum samples drawn during 36 hr after each dose, and a mean across-dose kinetic profile was determined for each subject. After a 6-mo washout period, the same subjects received 0.25 mg digoxin intravenously every 24 hr for 10 consecutive days. Samples were drawn every 12 hr during the first 9 days and at multiple points during 72 hr after the last dose. Mean kinetic variables for the single- and multiple-dose trials were as follows: elimination half-life (t1/2), 27.9 and 38.0 hr (r = 0.62); volume of distribution, 5.5 and 7.4 l/kg (r = -0.56); total clearance, 2.50 and 2.49 ml/min/kg (r = 0.19); urinary excretion t1/2, 40.9 and 37.9 hr (r = -0.14). Mean observed and predicted predose steady-state serum concentrations were 0.59 and 0.79 ng/ml (r = -0.02). Mean values of accumulation and elimination t1/2 were nearly identical (27.8 and 27.9 hr), but were not positively correlated (r = -0.64). Multiple-dose digoxin therapy leads to no systematic change in digoxin clearance. Single-dose kinetics is poorly predictive of the rate and extent of drug accumulation and of washout kinetics during and after multiple-dose therapy.

Adult↗
PubMed1979

[Biological availability of digoxin from a combination drug].

In a randomized cross-over study with 14 voluntary test persons the absolute biological availability of digoxin in Card-Dusodril 1/8 and 1/4 respectively was investigated. 6 test persons received 4 drag. Card-Dusodril 1/8 (= 0.5 mg digoxin), 8 test persons 4 drag. Card-Dusodril 1/4 (= 1 mg digoxin) orally, in comparison to the corresponding group with intravenously applied digoxin as standard. Based on the cumulative digoxin excretion in the urine an absolute biological availability of Card-Dusodril 1/8 of 79%, of Card-Dusodril 1/4 of 76% could be demonstrated. With regard to an average resorption of oral digoxin preparations of approx. 70%, the present values, which correspond in direct comparison to those of acetyl digoxin, can be considered good. Maximum serum levels were achieved after 86 +/- 6.8 minutes which also indicates a quick resorption.

Administration, Oral↗
PubMed1979

[Digoxin induced changes in the exercise ECG and its relation to plasma concentrations (author's transl)].

The effects of a single intravenous dose (1.5 mg) of diogoxin on the resting and exercise ECG were studied over several days in twelve normal subjects. Maximal ST-segment and T-wave changes were observed 24 h after drug administration. A significant ST-segment depression and decrease in T-wave amplicude were still observed on the 7th and 11th day after the glycoside dose, in spite of undetectable digoxin plasma concentrations. There was no correlation between digoxin plasma concentration and ECG-changes. In order to avoid false positive ischaemic ST-segment responses to exercise, a therapy with digoxin should be discontinued for at least 2 weeks before the exercise test.

Adult↗
PubMed1978

Absorption of oral tetracycline in patients with Billroth-II gastrectomy.

The bioavailability of a single 250-mg oral dose of tetracycline hydrochloride was studied in seven patients following Billroth-II gastrectomy in comparison with seven control subjects matched for age and body weight. There were no significance differences between control subjects and gastrectomized patients in the apparent lag time prior to the start of absorption (23.6 vs. 22.8 min), peak serum tetracycline concentration (1.72 vs. 1.75 microgram/ml), the time of attainment of peak concentrations (3.35 vs. 3.42 hr), the apparent first-order absorption half-life (1.8 vs. 1.4 hr), or the apparent first-order elimination half-life (8.0 vs. 8.7 hr). Completeness of tetracycline absorption, as judged by area under the 24-hr serum concentration curve, did not differ significantly between the two groups, nor did 24-hr urinary excretion of tetracycline. Thus the abnormalities of gastrointestinal structure and function produced by Billroth-II gastrectomy do not result in impairment of the rate and completeness of tetracycline absorption.

Absorption↗
PubMed1978

Spironolactone.

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Androgen Antagonists↗
PubMed1978

Dose-independent pharmacokinetics of digoxin in humans.

Nine healthy male volunteers received single 0.5, 1.0, and 1.5 mg. doses of intravenous digoxin in a randomized three-way crossover study. Multiple venous blood samples were drawn during 35 hours after each dose, and all urine was collected for 6 consecutive days. Concentrations of digoxin in serum and urine were determined by radioimmunoassay. Over-all mean values for kinetic variables were: distribution half-life, 0.35 hours; elimination half-life, 27.9 hours; volume of distribution, 5.46 liters/Kg; total clearance, 2.51 ml./min./Kg. The mean projected cumulative urinary excretion of digoxin was 70.1% of the dose; mean renal clearance of digoxin was 1.71 ml./min./Kg., not significantly different from creatinine clearance (1.50 ml./min./Kg.). None of the identifiable pharmacokinetic variables was significantly influenced by dose, suggesting that digoxin disposition is dose-independent in healthy individuals.

Adult↗