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H R Pratt-Thomas

Publications and source records attributed to H R Pratt-Thomas.

At least 19 recordsLinked to original sources
PubMed1986

Peter Pan stumbles.

Explore the source record for details and available documents.

Coronary Artery Bypass↗
PubMed1977

Embryonal carcinoma of the testis in elderly men.

A rare case of pure embryonal carcinoma of the testis in a black man in the tenth decade of life is presented, as well as a review of the literature on germ cell testicular tumors in men 60 years old or more. It is noteworthy that nearly 9 per cent of testicular tumors occur in this age group and a third of these tumors are of germ cell origin.

Aged↗
PubMed1977

Metastatic basal cell carcinoma. Report of four cases.

Four cases of metastasizing basal cell carcinoma, one occurring in the basal cell nevoid syndrome, are presented. Two patients are surviving without evidence of additional metastases. One patient died from cerebral involvement 31/2 years after a lymph node metastasis was established by aspiration biopsy. One patient died from complications of cerebral palsy one year after a metastasis to a regional lymph node was discovered in the primary resection of the neoplasm. Only 90 cases of metastases from basal cell carcinoma have been reported previously.

Adult↗
PubMed1976

Gonadoblastoma: clinicopathologic correlation in six patients.

Six patients with a total of nine gonadoblastomas are presented; three--and possibly a fourth--had dysgerminomatous overgrowth which was massive in two patients. Calcification detected by abdominal films was present in three sufficient for preoperative diagnosis. All patients were found to have a Y stem line on peripheral leukocyte chromosome cultures except one patient, who had a 46 XX/45 XO karyotype. She was found to have Y chromatin bodies in the germ cells of her tumor which was in a normal ovary found at exploration for an ectopic pregnancy. Three were found in virilized phenotypic females investigated for amenorrhea, and two for therapy of pelvic masses due to dysgerminomatous overgrowth. Y chromatin studies are reported on gonadal tissue.

Dysgerminoma↗
PubMed1976

Gonadoblastoma: histologic, ultrastructural, and histochemical observations in five cases.

In this series of gonadoblastomas it appeared that the germ cells were the motivating force underlying either tumor proliferation or regression. The ultrastructural morphology confirmed the presence of undifferentiated gonadal cells with active steroid synthesis by the interstitial cells. The Call-Exner-like bodies which showed extensive calcification were composed of basement membrane material containing a sulfated mucosubstance. A histochemical comparison with the noncalcifying Call-Exner bodies of a granulosa-cell tumor differed only in their glycoprotein content. The calcium deposits were identified as oriented hydroxyapatite crystals by electron diffraction, and it is proposed that the basement membrane material serves as a nucleation site for calcification. High serum testosterone levels were correlated with the presence solely of interstitial cells in one case. The finding of a gonadoblastoma without the presence of a Y chromosome contradicts earlier proposals concerning the requirement of a Y chromosome for germ cell proliferation.

Adolescent↗
PubMed1976

Carcinoma of supernumerary breast of vulva with bilateral mammary cancer.

Primary mammary cancer often develops at multiple sites in either one or both breasts, evidently the result of a common carcinogen acting in multicentric loci. The occurrence of carcinoma in accessory breast tissue has been recorded, including carcinoma in supernumerary breast tissue within the labium, although the latter is rare. A 62-year-old woman developed carcinoma of the right breast which was followed nearly five and one half years later by the occurrence of adenocarcinoma in supernumerary breast tissue within the left labium majus. Concomitantly, carcinoma was detected in the left breast. The three cancers exhibited histologic features compatible with primary rather than metastatic lesions. The development of primary carcinoma in both breasts as well as within ectopic mammary tissue in the labium appears to be the first recorded instance of such an event.

Breast Neoplasms↗
PubMed1976

Gonadoblastoma with tubal pregnancy.

A case of unilateral gonadoblastoma in association with a ruptured ectopic tubal pregnancy is presented. The patient had normal menstrual history prior to a missed period followed by abdominal pain and the passage of clots. The surgical specimens, in addition to the ruptured tubal pregnancy, showed nodular foci of typical gonadoblastoma in the right ovary, the remainder of the ovarian tissue being normal. The left ovary was subsequently removed and examination revealed normal constituents without evidence of tumor. Cytogenetic evaluation of peripheral leukocytes showed cells with a normal female sex chromatin complement, 46-XX, as well as cells with 45 chromosomes in which one of the X chromosomes was missing.

Adult↗
PubMed1975

Microorganism-like structures in Hodgkin disease. Electron microscopical demonstration.

Ultrastructural examination of lymph nodes from patients with untreated Hodgkin disease showed unique spherical structures that were found extracellularly and within vacuoles of reticulum cells, macrophages, mononuclear cells, and occasional tumor cells. These spheroids varied in size and internal composition possibly in relation to developmental stages, and resembled mycoplasma morphologically and in cellular distribution. The spheroids were found predominantly in the neoplastic areas in lymph nodes of four out of nine patients with Hodgkin disease of the mixed cell variety, but were not seen in other types of Hodgkin disease or reticulum cell sarcoma. The structures were much more numerous in the lymph nodes from young children with Hodgkin disease. A lymph node of one child, disclosed numerous extracellular structures resembling viral type C particles in addition to mycoplasma-like spheroids. The results indicate that subclinical infections may occur in Hodgkin disease and contribute to the histopathologic manifestations of the disease.

Adolescent↗