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Biomedical subjects

H R Wagner

Publications and source records attributed to H R Wagner.

At least 73 records · Page 4Linked to original sources
PubMed1978

Histamine-, norepinephrine-, and dopamine-sensitive central adenylate cyclases: effects of chlorpromazine derivatives and butaclamol.

A series of recently available derivatives (quaternary and hydroxylated) of chlorpromazine (CPZ) and butaclamol were evaluated with respect to antagonism of norepinephrine- (NE) (rat cerebral cortex), dopamine- (DA) (rat striatum) and histamine- (H) sensitive (rabbit cerebral cortex) adenylate cyclases. With incubated tissue slices (rat and rabbit cortices) CPZ-CH3, 7-OH-CPZ-CH3, beta-OH-CPZ and butaclamol displayed a capacity to inhibit either NE- or H- induced accumulation of adenosine cyclic 3',5'-monophosphate (cAMP). With the broken cellular enzyme responsive to DA, rather potent inhibition of enzyme activity (IC50 less than 24 micron) occurred with butaclamol, beta-OH-CPZ, 7,8,beta-triOH-CPZ, 7,8-dioxo-beta-OH-CPZ and 3,7,8-triOH-CPZ. It is concluded that the metabolites of CPZ contribute to the central therapeutic and/or side effects of the parent compound.

Adenylyl Cyclases↗
PubMed1978

Tetralogy of Fallot. Occlusion of the ventricular septal defect due to accessory tricuspid valve leaflet and an associated membranous aneurysm.

A unique case of tetralogy of Fallot is presented in a 3 7/12-yr-old white female. At surgical repair, a ventricular septal defect smaller than usual was demonstrated in the usual infracristal position. The ventricular septal defect was partially obstructed from the right side of the ventricular septum by adherence of an accessory tricuspid leaflet. An associated membranous aneurysm, presumably acquired, was occluding the ventricular septal defect at its outlet almost completely. The literature has been reviewed and the pathophysiology of this lesion is discussed, underlining the nature and plausible development of the membranous aneurysm.

Child, Preschool↗
PubMed1977

The applicability of inescapable shock as a source of animal depression.

Male rats (N = 27) were given initial experience with escapable shock, equivalent amounts of inescapable shock, or no shock. Measures were then obtained in the ensuing 15 hours on food intake, water intake, number of cage crossings, and weight change for all groups. Following this, animals were tested on an escape task. Inescapably shocked animals showed significant decreases in food and water consumption in comparison to both nonshocked and escapably shocked control rats. Weight gains were significantly decreased by exposure to shock irrespective of the availability of a coping response. Consistency of these findings with proposals suggesting that exposure to inescapable shock leads to a state of animal depression (learned helplessness) is discussed and compared to alternative stress explanations.

Animals↗
PubMed1977

Aneurysm of the membraous septum in ventricular septal defect.

An aneurysm of the membranous septum was found frequently in patients with ventricular septal defect; although appearance at catheterization during infancy was not common, aneurysms were detected in about half of the patients older than 2 years of age. A significant decrease in the left-to-right shunt occurred with the development of an aneurysm, but progression to complete spontaneous closure was not seen in any patient. In three older patients, an aneurysm of the membranous septum "disappeared" with time, even though complete spontaneous closure had not occurred.

Child↗
PubMed1976

Cineangiographic measurements with the help of a vertebral grid system.

Cineangiographic measurements of cardiac structures require knowledge of the magnification factor due to nonparallelity of the X-ray beams. A new method is presented to determine the magnification factor from cineangiograms based on the patient's height and the height of three vertebral bodies and the adjacent intervertebral distances. The method enables measurement of cardiovascular structures from projected cineangiographic films where the appropriate magnification factor is missing. Furthermore, doubtful magnification factors can be checked out as to their accuracy.

Body Height↗
PubMed1976

Congenital valvular aortic stenosis: clinical detection of small pressure gradient. Prepared for the joint study on the joint study on the natural history of congenital heart defects.

Clinical variables (from the history, physical examination, electrocardiogram and chest radiograph) were related to the pressure gradient measured between the left ventricle and the aorta in 434 young patients with congenital valvular aortic stenosis admitted to a national collaborative study. The aim was to devise a composite clinical criterion for the recognition of patients with a small pressure gradient, so as to expand the opportunity for avoiding cardiac catheterization in such patients. Flattened or inverted T waves in lead V6 were found to be inconsistent with mild disease. Therefore, a composite criterion, providing an estimate of pressure gradient, was developed for patients without T wave changes. The final criterion, based on multivariate analysis, involved only the intensity of the systolic murmor, the presence or absence of an early diastolic murmur, and voltages of the Q and R waves in lead V6. Patients with a low estimate by this procedure rarely had a large measured gradient. Only 3.7 percent (6 of 161) with an estimated gradient of less than 45 mm Hg had a gradient at cardiac catheterization of 80 or more mm Hg; none (0 of 32) with an estimated gradient of less than 30 mm Hg had a gradient of 50 or more mm Hg. This criterion should be helpful in avoiding unnecessary catheterization by identifying some patients with valvular aortic stenosis who have a small pressure gradient.

Adolescent↗
PubMed1976

Aneurysm of the membranous ventricular septum in transposition of the great arteries.

In patients with transposition of the great arteries (TGA), both the D- and L- forms, an aneurysm of the membranous ventricular septum (AMS) produces subpulmonic stenosis due to the higher right ventricular pressure which forces the aneurysm to protrude into the left ventricular, i.e., subpulmonic, outflow tract. The clinical signs and symptoms, hemodynamic findings as well as surgical results were analyzed in eight patients with TGA and AMS. The presence of an AMS should be suspected from hemodynamic data consisting of a combination of elevated left ventricular pressure, gradient across the left ventricular outflow tract and presence of a small ventricular septal defect with or without pulmonary artery hypertension. The AMS can be demonstrated by a right ventricular injection in the lateral view. The anomaly needs to be corrected at the time of the Mustard procedure. If uncorrected it may lead to postoperative death or progressive obstruction. In the presence of an aneurysm even small ventricular septal defects should be closed by a patch and the aneurysm should be excised.

Child, Preschool↗
PubMed1976

Inhibition of lactation in rabbits by 2-Br-alpha-Ergokryptine-mesilate (CB154).

The lactating rabbit responds to single injections of the inhibitor of prolactin secretion 2-Br-alpha-ergokryptine-mesilate (CB 154) by a reversible reduction in milk yield, which is dose-dependent. Inhibition of galactopoiesis by CB 154 is also observed in rats, dogs, pigs and in woman, but not in goats and cattle. This points to a difference in prolactin dependence of galactopoiesis in the two groups.

Animals↗
PubMed1975

Anatomically corrected malposition of the great arteries (S, D, L).

Two autopsy-proved cases are presented of a rare form of congenital heart disease, anatomically corrected malposition (S, D, L). Anatomically corrected malposition means that despite the abnormal relationship between the great arteries, the aorta arises nonetheless above the anatomically left ventricle and the pulmonary artery originates above the anatomically right ventricle. (S, D. L) briefly indicates the segmental set or combination: situs solitus of viscera and atria (S), ventricular D-loop (D), AND L-MALPOSITION OF THE GREAT ARTERIES (L). These are the first cases of anatomically corrected malposition (ACM) in whom the presence of a subaortic muscular conus only has been documented pathologically. This established that ACM can occur with a subaortic conus, as well as with a bilateral conus. From the diagnostic standpoint, the distributions or epicardial courses of the coronary arteries are recommended as a helpful approach to ventricular identification. This diagnostic method has widespread angiocardiographic and surgical applications. Symbolic terminology, exemplified by anatomically corrected malposition (S, D. L) is brief and accurate. This approach may conveniently be applied to many other forms of comples congenital heart disease, and it considerably facilitates computer data processing.

Angiocardiography↗