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Biomedical subjects

H Röckl

Publications and source records attributed to H Röckl.

At least 19 recordsLinked to original sources
PubMed1990

[Microbial ecosystems of the skin in antimicrobial therapy].

Healthy human skin provides wet, dry, and sebaceous habitats for well-adapted microbes living in a community and occupying three-dimensional spaces of the skin. These resident microbes of the skin are reduced either intentionally or unintentionally under systemic or topical antimicrobial therapy, e.g. in acne or tinea versicolor. As a result, quantitative or qualitative alterations of the microbial communities might ensue, including the selection of multiresistent variants in a habitat or a total change of the microbial community followed by the so-called gram-negative folliculitis. Skin disinfectants are antimicrobially effective within 30 to 60 seconds. Their long-term efficacy varies according to the specific substance. Moreover, the antimicrobial efficacy of skin disinfectants may vary to a considerable degree in the individual habitats of the human skin.

Anti-Bacterial Agents↗
PubMed1988

[Therapy of malignant melanoma with beta-interferons].

Since June, 1985, we have been treating 18 evaluable patients suffering from high risk melanoma with human beta-interferon (HBIF), 10 of the patients received HBIF infusions, 8 patients got subcutaneous injections into the regional lymph nodes. In some of the cases, this treatment resulted in obviously prolonged survival times; at present, however, the effect of HBIF is still beyond calculation.

Combined Modality Therapy↗
PubMed1981

[Leukocytoclastic vasculitis due to drug allergy presenting as generalized pustular exanthema].

A 68-year-old man who was treated for febrile angina with gentamicin, doxycycline, phenoxymethylpenicillin K, and minocycline developed a generalized pustular exanthema favoring the predilected areas (hands, feet). Apart from a subepidermal pustule, the most noteworthy histological finding was a pronounced leukocytoclastic vasculitis. After disappearance of the skin lesions an intradermal test using cilligen (penicilloyl-polylysin) was conducted. The test gave a strongly positive early reaction, and 48 h after this an acute pustular outbreak developed analogous to the original manifestation. Doxycycline tested late, produced no exacerbation even though it was positive in the intradermal test. This pustular allergical drug rash can be classified as a vasculitis leucocytoclastica allergica which, as we know, appears in various clinical forms. It does not form a new disease entity. Terms used so far, such as "pustular necrotizing angiitis", "generalized pustular drug rash", "acute generalized pustular bacterid", "pustulosis acuta generalisata", only partially correspond to the actual pathoetiology.

Aged↗
PubMed1978

[Attempts of sensitizing guinea-pigs with five different derivates of para-substituted benzene (author's transl)].

Skin tests with derivatives of para-substituted benzene were carried out at 4 different concentrations on a total of 160 guinea pigs. Results were evaluated macroscopically and histologically. Each substance was tested on 32 animals. Sensitization was obtained with p-aminodiphenylamine in about 50%, with p-toluylenediamine in about 25%, with 1% and 2% p-phenylenediamine in 62% with 5% p-aminoazotoluene in 37%, whereas no sensitization was observed with p-aminobenzoic acid. Thus, p-aminodiphenylamine, p-toluylenediamine and p-phenylenediamine must be regarded as highly sensitizing agents, whereas p-aminozotoluene and p-aminobenzoic acid seem to be less effective respectively non sensitizing.

Animals↗
PubMed1977

[Staphylodermia superficialis circinata. The 5th obligatory cutaneous paraneoplasia].

Clinical observations on two cases of staphylodermia superficialis circinata are reported. This rare variation of superificial staphylococcal skin infection is identical with the "erythema necroticans migrans". As this cutaneous manifestation is highly associated with malignant internal diseases it must be regarded as a "cutaneous paraneoplasia". Out of 14 cases of erythema necroticans migrans, so far published this dermatosis occured in 13 patients suffering from pancreatic cancer. Association with pancreatitis was demonstrated in one case. In both cases herein reported the cutaneous manifestations were associated with a carcinoma of the pancreas and with cervix cancer. Extreme loss of weight, atrophic glossitis, therapy-resistant anemia and a slight diabetes are extra-cutaneous symptoms of this paraneoplastic syndrom.

Adult↗
PubMed1976

[Perioral dermatitis].

Intensive investigations between 1969-1974 on 245 patients with perioral dermatitis are reported. Results are discussed with special regard to clinical behaviour, histology, differential diagnosis and etiology of the disease. Eczematous sources, bacterial and mycotic infections can be ruled out as etiological factors. Therapeutical considerations are discussed.

Adolescent↗
PubMed1975

[Drug-induced allergic skin reactions of a cutaneous vascular type (author's transl)].

Among drug exanthemata (AE) are included allergic reactions of the cutaneous system which are of a cutaneous vascular type after hematogenous supply of the allergen, which run an immunological course according to the early, Arthus or late type. They are manifested morphologically as urticaria (monosymptomatic or a partial symptom of an anaphylactic or serum sickness syndrome), as macular or maculopapular exanthema (9 days AE) predominantly after ampicillin, as a fixed AE, as Lyell's disease (fatal in about 30% of cases), as erythema multiforme-like AE, as purpura (allergic vasculitis, "carbromal purpura"), as rare lichenoides or nodose AE and as erythematodes-like drug reactions.

Adult↗