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Biomedical subjects

H Radu

Publications and source records attributed to H Radu.

At least 19 recordsLinked to original sources
PubMed1978

Computer simulation of calcium-induced myotonia.

In an extensive research project on myotonia, the ionic mechanisms which are at the basis of the phenomenon of calcium-induced myotonia have been taken into consideration. A mathematical model of a muscle fibre was constructed to demonstrate the possibility that anomalous values of the membrane permeability to Calcium ions have an active part in the genesis of myotonia.

Action Potentials↗
PubMed1977

Focal abnormalities in mitochondrial distribution in muscle. Two atypical cases of so-called "central core disease".

Describing two new cases of so-called Central Core Disease, the authors revealed certain atypical features: The cores were formed in central as well as in peripheral position; they were observed in some apparently type II fibers; typical "structured" and "unstructured" cores coexisted with "reversed" core. Starting from this pictures a cycle of core formation was imaginated supposing to be initiated as the consequence of abnormal functional interrelationship between muscular and neural components in early myogenesis.

Adult↗
PubMed1977

Myotubular (centronuclear) (neuro-)myopathy. I. Clinical, genetical and morphological studies.

Five new cases of myotubular (centronuclear) (neuro-)myopathy are presented. Myometric studies revealed type I fibre atrophy and mispositioned nuclei, at various stages between the myotubular structure and the normal subsarcolemmic position. Certain morphological changes, for instance target structures, suggest denervation involving the fibres in an early stage of myogenesis; differentiation seems to be more affected than growth. The genetic defect has an autosomal recessive mode of inheritance with penetrance and degree of expressivity varying from one case to another in the three families.

Adult↗
PubMed1975

Duchenne muscular dystrophy and poliomyelitis. A study of dystrophic-denervated muscle.

A systematic study of dystrophy-denervation in human muscle showed minimal morphometabolic differences between dystrophic and dystrophic-denervated muscle. The only certain conclusion is that denervation influences the rhythm of evolution of the dystrophy without impressing any of the few characteristics considered at present as peculiar to denervation.

Child↗
PubMed1975

Identification of Duchenne muscular dystrophy carriers. Electron microscopical investigation of skeletal muscle.

In order to identify a subclinical dystrophy, muscle biopsy specimens from 15 mothers of boys with Duchenne muscular dystrophy were studied by electron microscopy. Genetic investigations and biochemical determinations were not conclusive for a diagnosis of the carrier state. The fine structural lesions were sufficient to vertify the diagnosis of a subclinical dystrophy, and our findings were in agreement with other investigators. However, original intranuclear filamentous formations were noted in one case.

Adult↗