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H Razvi

Publications and source records attributed to H Razvi.

11 recordsLinked to original sources
PubMed2005

Ureteroscopy for pediatric urolithiasis: an evolving first-line therapy.

OBJECTIVES: To present in a retrospective report a contemporary series of patients aged 14 years and younger who were treated for stones with ureteroscopy at our institution from 1991 to 2002. With the improvement and miniaturization of ureteroscopes and ancillary instruments, the endoscopic treatment of renal and ureteral calculi in children has become more feasible. METHODS: A retrospective chart review was performed of 23 patients aged 14 years and younger who had undergone ureteroscopy for the treatment of ureteral or renal calculi at our institution. RESULTS: A total of 27 stones were treated in 23 patients. Of the 27 stones, 18 were in the distal ureter, 5 in the mid ureter, 2 in the proximal ureter, and 2 in the renal pelvis. Ureteral dilation was performed in 4 (17.4%) of the 23 patients. The lithotripsy modalities used were holmium:yttrium-aluminum-garnet laser in 16 (69.6%), electrohydraulic lithotripsy in 3 (13%), a combination of holmium laser and electrohydraulic lithotripsy in 2 (8.7%), and basket extraction alone in 2 (8.7%) of 23 patients. Ureteral stents were placed in 21 (91.3%) of 23 patients. The average operative time was 46.9 minutes (range 15 to 92). In 21 (91.3%) of 23 patients, postoperative imaging was available and revealed that 20 (95.2%) of the 21 patients were rendered stone free. Two patients were lost to follow-up. No intraoperative complications occurred. One patient was treated postoperatively with intravenous antibiotics for transient fever. CONCLUSIONS: Ureteroscopy is safe and effective in the management of ureteral and renal calculi in children. In our institution, it has emerged as a valid first-line therapy for the treatment of pediatric urolithiasis.

Adolescent↗
PubMed2004

Results of shockwave lithotripsy for pediatric urolithiasis.

BACKGROUND AND PURPOSE: Shockwave lithotripsy (SWL) is widely practiced in the management of pediatric urolithiasis. However, the efficacy, need for ancillary procedures, and treatment-related complications are not as clearly defined as in the adult population. We reviewed the outcomes of SWL in the pediatric population at our lithotripsy unit. PATIENTS AND METHODS: A retrospective review of all patients </=16 years of age treated with SWL between January 1991 and June 2002 was undertaken. One hundred patients with 115 stones underwent 131 SWL procedures (115 first treatments, 16 retreatments). The mean age was 10.7 years (range 10 months-16 years). Stone locations were as follows: caliceal 42.6%, renal pelvic 27%, and ureteral (30.4%). The mean stone size was 7.8 mm (range 2-23 mm). Risk factors for stone formation, the need for secondary therapies, and treatment-related complications were noted. The stone-free rate for a single-session SWL procedure, defined as complete absence of stone fragments on plain film, intravenous urography, or renal ultrasonography, was calculated based on 3-month follow-up. The efficiency quotient (EQ) was also calculated. RESULTS: Risk factors were identified in 31 children (27.0%), including metabolic and anatomic abnormalities. Patients with a risk factor were less likely to be stone free after one SWL session than those without risk factors (31.7% v 64.7%; P < 0.001). General (74.8%), neurolept (24.4%), and epidural (0.8%) anesthesia were utilized. Ureteral stents were placed in 25% of treatments. There were no intraoperative complications. Minor complications were seen in 4.6% of patients. Ancillary procedures were required in 10 patients. Following initial SWL treatment, 60.2% of patients were stone free. The retreatment rate was 13.9%. Following a second treatment, the stone-free rate increased to 68%. The EQ was 54.3. CONCLUSION: Employing a strict definition of treatment success, single-session SWL in our series offers moderate efficacy in the pediatric population. Patients who have a large stone or risk factor such as an anatomic abnormality are less likely to become stone free and might better undergo an endourologic procedure.

Adolescent↗
PubMed2003

Malignancy in horseshoe kidneys: review and discussion of surgical implications.

OBJECTIVE: Horseshoe kidney is one of the most common congenital anomalies of renal structure. Not infrequently, surgical management of both benign and malignant disorders is required in patients with horseshoe kidney due to the susceptibility to certain conditions. The literature suggests a greater proclivity to certain renal tumors with this anomaly. We present three cases of malignancy in horseshoe kidneys. The unique technical challenges presented by these cases and the surgical approaches are discussed. METHODS: Three patients with tumors involving horseshoe kidneys are reviewed and their management discussed. RESULTS: Two patients were found to have renal cell carcinoma (RCC) and one had transitional carcinoma (TCC). Computed tomography (CT) and angiography were used in the work-up and preoperative planning of these cases. One patient with RCC received pre-operative renal artery embolization. Partial nephrectomy was performed in each patient with an aim at early vascular control of the tumors, identification of the collecting systems and ureters, as well as ensuring a 1 cm surgical margin. No patient required dialysis post-operatively. One patient died in the early post-operative period of a myocardial infarction; one patient developed brain metastases 18 months post-operatively, received palliative radiation and is alive 42 months after surgery; the other patient was free of disease for approximately 36 months but recently developed osseous metastases to her pelvis. CONCLUSIONS: Techniques developed for partial nephrectomy may be used in the treatment of tumors in horseshoe kidneys. Survival is related to the grade and stage of disease.

Aged↗
PubMed2002

Retroperitoneal fibrosis: a case report of spontaneous resolution.

AIM: The purpose of this case report is to document an occurrence of spontaneous resolution of idiopathic retroperitoneal fibrosis and to review the investigation and management of this unusual condition. MATERIALS AND METHODS: A detailed case summary of a patient with retroperitoneal fibrosis is presented. Current citations in Index medicus from the English-speaking literature of relevance to the topic were reviewed. CONCLUSIONS: In this patient who refused open surgical intervention, bilateral stent placement allowed stabilization of renal function. CT-guided biopsy did not reveal malignancy. Serial CT imaging demonstrated gradual disappearance of the retroperitoneal mass. From the literature review, spontaneous resolution of this condition appears to be a rare phenomenon. Although often utilized, CT-guided biopsy may fail to exclude the presence of malignancy. Open surgical biopsy of the retroperitoneal mass and ureterolysis remain the standard of care for operative candidates. Establishing renal drainage and considering a trial of steroids or surveillance may be an option in carefully selected individuals.

Aged↗
PubMed2001

Randomized trial of 10 mL and 20 mL of 2% intraurethral lidocaine gel and placebo in men undergoing flexible cystoscopy.

PURPOSE: To determine if 20 mL of 2% intraurethral lidocaine gel is superior to 10 mL of 2% lidocaine or sterile lubricant for flexible cystoscopy in men. PATIENTS AND METHODS: A randomized, double-blind, placebo-controlled trial was conducted. Sixty men scheduled to undergo diagnostic flexible cystoscopy were randomized to receive either 20 mL of placebo gel (Group I), 10 mL, of 2% lidocaine gel (Group II) or 20 mL of 2% lidocaine gel (Group III). A penile clamp was applied for 15 minutes to ensure consistent indwelling time in all patients. Patients recorded their pain on a 10-cm non-graphical visual analog scale prior to cystoscopy as a baseline, during the procedure, and immediately after the procedure. Patients also recorded their pain and willingness to have the same anesthetic on a 4-point descriptive scale. Heart rate and mean arterial blood pressure (MAP) were recorded at specific intervals throughout the procedure, and increases in mean arterial pressure were considered objective evidence of patient pain. RESULTS: Pain perception was not statistically different in the groups (Group I 4.65, Group II 3.93, Group III 3.57; P = 0.406). Pain assessment and willingness to have the same anesthetic also did not differ statistically among the groups. Similarly, differences in the increases in MAP were not statistically significant between groups. CONCLUSION: Instillation of 20 mL or 10 mL of 2% lidocaine gel has no advantage over plain lubricant in providing anesthesia for flexible cystoscopy in men.

Adult↗
PubMed2000

Comparison of human telomerase reverse transcriptase messenger RNA and telomerase activity as urine markers for diagnosis of bladder carcinoma.

BACKGROUND: Human telomerase reverse transcriptase (hTERT) has been identified as the catalytic subunit of telomerase ribonucleoprotein complex known to be required for cellular immortality and oncogenesis. Although human telomerase activity (hTA) is considered as a general marker for malignancy based on its presence in most malignant tumors including bladder cancer, its detection in urine is affected by many factors. The objective of this study was to compare the clinical utility of detecting urine hTERT messenger RNA (mRNA) by multiplex hTERT/GAPDH RT-PCR and urine hTA by telomerase repeat amplification protocol (TRAP) in the diagnosis of bladder cancer. METHODS AND RESULTS: Cystoscopy urine samples or bladder washes prospectively collected from 35 patients with confirmed (35) or clinically suspected (5) transitional cell carcinoma (TCC) of the bladder were examined by TRAP, hTERT/GAPDH RT-PCR, and urine cytology. The control group comprised 21 healthy volunteers and 3 patients without TCC. The hTERT/GAPDH RT-PCR test showed significantly higher diagnostic sensitivity than TRAP assay (94.3% vs 48.6%, P <.001) and urine cytology (95.2% vs 61.9%, P =.008) for confirmed TCCs. In particular, for superficial TCCs low grade (I-II), the hTERT/GAPDH RT-PCR test outperformed TRAP (90% vs 25%, P <.001) and urine cytology (91.7% vs 58.3%, P =.46). The overall specificity of the hTERT/GAPDH RT-PCR, TRAP and urine cytology was 92% (22/24), 100% (24/24), and 100% (3/3), respectively. A positive hTERT mRNA expression was also detected in urologic specimens from 3 patients with previous history of TCC, 3 to 6 months before cystoscopic evidence of cancer. CONCLUSION: In this pilot study, the hTERT mRNA expression in urine sediments is a more sensitive marker for diagnosis of TCC of the bladder than hTA and cytology. However, there is a higher false-positive rate.

Adult↗
PubMed1998

Microwave thermotherapy for benign prostatic hyperplasia with the Dornier Urowave: results of a randomized, double-blind, multicenter, sham-controlled trial.

OBJECTIVES: To study the efficacy and safety of a new transurethral microwave thermotherapy device (the Urowave) in the treatment of men with clinical benign prostatic hyperplasia (BPH) in a randomized, double-blind, sham-controlled trial. METHODS: A total of 220 patients (mean age 66.2 years) with clinical BPH, an American Urological Association symptom index (AUA SI) of 13 points or more, and a peak flow rate of 12 mL/s or less were enrolled and randomized 2:1 for active versus sham treatment. All treatments were conducted as an outpatient procedure under local anesthesia, with oral sedation and analgesia only. Patients were followed up at 1 week and 1, 3, and 6 months after treatment. RESULTS: The treatments were well tolerated, and no patient received general or spinal anesthesia. The AUA SI dropped from 23.6 to 12.7 points at 6 months (P < 0.05) in the active group and from 23.9 to 18.0 points in the sham-treated group (P < 0.05, between-group difference). Statistically significant improvements were also noted for peak flow rate (7.7 to 10.7 mL/s at 6 months for active treatment, 8.1 to 9.8 mL/s for sham treatment, P < 0.05, between-group difference) and for average flow rate. A decrease in AUA SI of more than 30% was achieved in 72% versus 38% of patients (active versus sham treatment, respectively) and more than 50% in 50% versus 19% of patients. In general, active Urowave-treated patients perceived "a lot" of improvement, whereas sham-treated patients perceived "a little" to "some" improvement. More of the actively treated patients had dysuria and urgency after treatment, and ejaculatory dysfunction (e.g., hematospermia) was more common in actively treated patients as well. Secondary urinary retention after removal of the catheter occurred in 8 patients (5.4%). CONCLUSIONS: The Dornier Urowave transurethral microwave thermotherapy device for treatment of clinical BPH is effective in decreasing symptoms and bother and improving quality of life and flow rate and is superior to sham treatment. Patients perceive a great deal of improvement, independent of their baseline symptom severity. Adverse events are in general transient and mild in nature. Extended follow-up is necessary to document long-term durability of improvements.

Aged↗
PubMed1996

Eutectic mixture of local anaesthetics is not effective for extracorporeal shock wave lithotripsy.

PURPOSE: Eutectic mixture of local anaesthetics (EMLA) produces cutaneous analgesia. This randomized, double blind, placebo controlled study evaluated the efficacy of EMLA cream during extracorporeal shock wave lithotripsy (ESWL) using the Dornier MFL 5000 lithotripter. METHODS: Patients scheduled to undergo lithotripsy of renal or pelviureteric junction stones were randomized to receive either 30 g EMLA cream (E) or placebo (P) over the kidney area 60-90 min before the procedure. During lithotripsy all patients received alfentanil via a PCA machine (dose--10 mu.kg-1, lockout time--three minutes, no basal infusion). Additional bolus doses of 5 micrograms.kg-1 alfentanil were administered by the anaesthetist if analgesia was inadequate. Visual analogue scores (VAS) for pain were documented prior to application of the cream. On arrival in the post anaesthesia care unit VAS pain scores were documented for maximum pain and average pain felt during the procedure as well as for satisfaction of the analgesic technique used. Total time spent in the PACU and the Aldrete scores on arrival were compared. RESULTS: Eighty-three patients completed the study. Demographic data were similar between the two groups. Also, VAS for maximal pain, average pain and satisfaction and the total number of shock waves were similar although the EMLA group received more shock waves at the lower energy level (kV) (P < 0.0001). Total dose of alfentanil, dose as boluses, rate of alfentanil use, total number of PCA attempts and missed attempts were similar. The incidence of adverse events such as bradypnoea, airway obstruction, transient hypoxaemia, pruritus and nausea were small and similar. There was a slightly higher incidence of inadequate analgesia documented by the anaesthetist in the EMLA group. There was no difference between the groups with regards to duration of stay in the PACU, incidence of nausea or Aldrete scores on admission to PACU. CONCLUSIONS: During lithotripsy EMLA cream does not modify the pain perceived nor does it have any opioid sparing effect. It does not facilitate early discharge from the PACU.

Adult↗
PubMed1992

Management of urinary calculi during pregnancy.

Renal calculous disease is an infrequent but not insignificant occurrence during pregnancy. In 50 to 80% of the cases conservative management is appropriate and the stone will pass spontaneously. Should intervention be required, recent advances in stone management and techniques for urinary tract drainage may be successfully applied to the obstetric population. Concerns regarding surgical and anesthetic risks, and the potential hazards of radiation exposure during pregnancy favor a minimally invasive approach with definitive treatment late in pregnancy or post partum. We review our experience during a 5-year period in managing 29 patients with urinary calculous disease during pregnancy. Based on our experience and review of the literature an algorithm for treatment of urolithiasis during pregnancy is proposed.

Adolescent↗
PubMedDate not supplied

Treatment of caliceal diverticular stones: transdiverticular percutaneous nephrolithotomy with creation of a neoinfundibulum.

PURPOSE: To evaluate transdiverticular percutaneous nephrolithotomy (TDPN) with creation of a neoinfundibulum in the treatment of caliceal diverticular stones. PATIENTS AND METHODS: Between 1990 and 1998, 18 patients with symptomatic calculi in caliceal diverticula underwent TDPN. Transdiverticular puncture into the renal collecting system with creation of a neoinfundibulum was used, eliminating the need for prolonged probing with a wire for the neck of the diverticulum. Eight diverticula were upper polar, six were interpolar, and four were in the lower pole. Stones were endoscopically treated with use of Lithoclast (Electromedical Systems, Lausanne, Switzerland), graspers, ultrasound, or a combination of these methods. RESULTS: Sixteen kidneys (89%) were rendered stone-free at discharge. Two kidneys (11%) were left with stone fragments of 5 mm or smaller. Hospital stay ranged from 3 to 15 days (average, 7 days). Procedure time ranged from 45 to 169 minutes (average, 87 minutes). One patient developed a left renal-pleural fistula, which closed 1 week after chest tube drainage. No other complications were encountered for an overall complication rate of 6%. CONCLUSION: TDPN is a safe and effective method for treating caliceal diverticular stones, with a complication rate comparable to other methods.

Adult↗