Transcervical sampling: a preliminary prospective study.
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Biopsy↗
Biomedical subjects
H Rhali
Publications and source records attributed to H Rhali.
[Are desquamated trophoblastic cells retrieved from the cervix suitable for a prenatal diagnosis?].
Prenatal diagnosis based on sampling of fetal tissues, amniotic fluid or chorionic villi is associated with the risk of miscarriage and fetal damage. These risks would be avoided if diagnosis could be performed in desquamated trophoblast cells recovered non-invasively from the maternal cervix. We report on our experience of fetal karyotyping on endocervical lavage using in situ hybridization (FISH) and DNA amplification (PCR) fetal sex was correctly predicted in 8/10 cases by FISH and in 6/10 by PCR. FISH appeared to be a reliable technique for karyotyping when trophoblast can be recovered from the maternal endocervix (8/10).
Female↗