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Biomedical subjects

H Riedl

Publications and source records attributed to H Riedl.

At least 19 recordsLinked to original sources
PubMed2000

Modulation of the atopy patch test reaction by topical corticosteroids and tar.

BACKGROUND: Pharmacologic studies in atopic eczema (AE) are difficult to standardize. Patients with AE differ in the stage of their skin disease (acute, subacute, chronic). OBJECTIVE: This study was designed to assess macroscopic and microscopic effects of pretreatment with topical glucocortico-steroids (GCSs) and tar on the atopy patch test (APT) reaction in patients with atopic eczema. METHODS: Nonlesional skin of the back of patients with AE (n = 6) was treated for 3 weeks at 3 different sites with triamcin-olonacetonide 0.1% in cetamacrogol ointment (GCSs), pix liquida 10% in cetamacrogol ointment (tar), and cetamacrogol ointment (vehicle), respectively. APTs were performed, and biopsy specimens were taken from all these sites (time = 0 and 24 hours) for immunohistochemical analysis. RESULTS: Treatment with both GCSs and tar was able to reduce the macroscopic outcome of the APT reaction. Furthermore, both treatment modalities had an almost equally inhibiting effect on the influx of T cells, eosinophils, and CD1(+), RFD1(+), IFN-gamma(+), and IL-4(+) cells, as well as on the percentage of vessels expressing the adhesion molecules vascular cell adhesion molecule 1 and E-selectin in response to epicutaneous aeroallergen challenge. CONCLUSION: Although both treatments significantly reduced the various cellular constituents of allergic inflammation, all cell types remained present. In addition, this study shows that the APT can be used to evaluate the effect of topical anti-inflammatory treatments on allergic inflammation in patients with AE.

Administration, Topical↗
PubMed2000

Attraction of adult Rhagoletis indifferens (Diptera: Tephritidae) to unbaited and odor-baited red spheres and yellow rectangles.

Five sizes of red spheres (4, 6, 8, 10, and 12 cm diameter) and 2 orientations of yellow rectangles (vertical and V) were evaluated as unbaited sticky-coated traps for western cherry fruit flies, Rhagoletis indifferens Curran, in unmanaged cherry trees in Washington and Oregon. Red spheres that were 10 cm in diameter attracted more flies than red spheres that were 8 or 12 cm in diameter and significantly more flies than 4- or 6-cm spheres and yellow rectangles of either orientation. In a 2nd test, red spheres (10 cm diameter) baited with ammonium carbonate alone or ammonium carbonate plus putrescine attracted significantly more R. indifferens than similar spheres baited with ammonium acetate alone, putrescine alone, 3-methyl-1-butanol alone, or combinations of these substances. In a 3rd test, vertical yellow rectangles baited with ammonium carbonate alone attracted numerically more R. indifferens than any of the aforementioned substances alone or in combination. We discuss the potential value of 10-cm red spheres baited with ammonium carbonate for monitoring and direct control of R. indifferens.

Animals↗
PubMed1983

Transformation of the structure of collagen. A time-resolved analysis of mechanochemical processes using synchrotron radiation.

Mechanochemically induced molecular transformations of collagen fibres were analysed using time-resolved small-angle diffraction spectra and histomechanical measurements. In particular, the influence of aqueous and methanolic perchlorate solutions was examined. According to a transformation continuing from the periphery towards the centre, the macroscopic contraction that is completed less than five minutes after incubation with perchlorate is caused by peripherally transformed fibrils only, whereas the centrally situated fibrils first undergo an accordion-like folding, but after more than 20 minutes are transformed similarly. The triple-helical transformation is preceded by a structure-breaking effect on structural water that can be monitored in time-resolved diffraction spectra. The combined loss of meridional low-angle reflections and cross-striated fibrils in micrographs is irreversible. By dialysis of colloidally dissolved collagen against a solution of ATP, however, segment-long spacing aggregates are obtained. Under isometric conditions, an instantaneous transformation of intermittent regions leads to an increase in the long period of adjacent, still structured regions of the same fibril that is correlated with a delayed increase in tension in the fibre. Increase of tension under isometric conditions as well as the flow-properties of a fibre relaxed in perchlorate are interpreted in terms of the parallel sliding of subunits of varying lengths, which has been demonstrated by diffraction analysis.

Animals↗
PubMed1979

[Preliminary physiological and psychological results under various electroclimatic conditions (author's transl)].

Before the start of a research project which was to stretch over a period of several years, characteristics of the control space were to be defined. Therefore the influence of spherics and 50 Hz-alternating fields in the unscreened control space were studied.--Pupils (Foster children) were the test subjects. Each test subject was subjected to the conditions of the control space as well as the testing space.--Two classes of parameters were studied. Blood sugar, blood pressure and pulse rate were recorded as physiological dimensions. Short-term memory, powers of concentration as well as the subjective well-being were the psychological parameters.--As to the parameters examined, no significant difference between testing and control space conditions was recorded. In order to examine whether the climatic factors of the control space have an antagonistic effect on the variables in question, their influence was studied separately in two further investigations. In order to clarify this problem, spherics-impulses in the 10 Khz range were given in screened space ("Vorversuch 2"/preliminary experiment 2), then--in, "Vorversuch 3"/preliminary experiment 3 - a 50 Hz-alternating field was applied. For each of the climatic factors under examination the influence on each single parameter was negative. The assumption of an antagonistic effect which would hinder the definition of standard spatial conditions was thereby shown to be incorrect.

Adult↗
PubMed1977

[Disordered fibrillar structure in ruptured tendons (author's transl)].

Areas of disordered fibrillar structure similar to kinking deformities have been observed in specimens from ruptured tendons. It seems possible to compare this phenomenon with experimentally produced deformations. The significance for the pathomechanics of tendon rupture is discussed.

Achilles Tendon↗
PubMed1977

[Kinking deformities in collagen (author's transl)].

The affect of stretch on collagen was investigated. Alterations of mechanical dimensions and thermostability of fibrils were measured and changes in fine structure determined by x-ray diffraction and electronmicroscopy. Collagen underwent changes both in tensile strength and fine structure following stretch beyond the physiological range. The severity of these changes depended both on the degree of stretch and the cross-link density of the collagen Fibrils either became split into bundles consisting of subfibrillar units or showed circumscribed kinking deformities. The mechanism producing kinking was investigated. It is possible that a connection exists between fibrillar kinking and tendon rupture.

Animals↗
PubMed1976

[Aetiology of dupuytren's contracture (author's transl)].

Regarding experimental data on the multi-factorial reduction of the thermostability of collagen, the following sequence of the mechanism of Dupuytren's contracture is discussed: 1. Hereditary or acquired weakness of fibres of the palmar fascia 2. Further disturbance of the physical property of collagen by the cumulative effects of mechanical, i.e. traumatic, influence. 3. By this means an induced stepwise shrinkage of released fascial fibres in body temperature. 4. Stabilisation of the shortening (contracture) by development of collagen. This hypothesis is supported by histological, polarizing-microscopic, electron-microscopic and chemical results.

Amino Acids↗