Biomedical subjects
Publications and source records attributed to H Robbins.
It is shown that, under certain assumptions, one can estimate the difference between the effect of a treatment and that of a placebo even when the treatment has been given to all and only those patients who are at risk (as evidenced by a screening examination).
Methods are presented for the estimation of a treatment effect based on before- and after-treatment values, where for ethical reasons all and only those patients are treated whose before-treatment values exceed a given constant.
Linear empirical Bayes estimators have been obtained for means and variances that apply to random sampling from populations whose structure is unknown or only partly known.
Two cases are presented in which allograft reconstruction followed wide resection of recurrent, aggressive aneurysmal bone cysts of the distal fibula. The authors find that allograft implantation provides a safe and effective method of reconstruction.
Given two statistical populations with unknown means, we consider the problem of sampling chi 1, chi 2, ... sequentially from these populations so as to achieve the greatest possible expected value of the sum Sn = chi 1 + ... + chi n. In particular, for normal populations, we obtain the optimal rule and study its properties when the average of the two population means is assumed known, and exhibit an asymptotically optimal rule without assuming any prior knowledge about the population means.
Intramuscular myxomas are relatively rare, benign, soft tissue neoplasms. They must be differentiated from other, more malignant lesions, such as myxoid liposarcoma, before definitive treatment is undertaken. The treatment of choice is wide local excision.
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Methylprednisolone acetate injections into bone cysts are as effective a treatment as curettement and packing. More than one injection may be necessary since recurrences have been seen in half the cases treated with a single injection. Fracture of the cystic part may occur before or after injection if bony filling has not taken place. The fracture may be serious if it involves the neck of the femur. The method is safe and does not result in an unsightly scar. Solitary eosinophilic granulomata of bone also reportedly respond positively to direct injections fo methylprednisolone into the lesion by signs of healing and with relief of pain.
The Mental Health Association was founded in 1909 as a citizen advocate organization for the mentally ill. Today it embraces more than a million members in nearly 850 chapters nationwide and conducts numerous programs designed to prevent mental illness, promote mental health, and improve mental health services. In recent years it has played an increasingly active role in influencing mental health policy at the federal level. This article focuses on the association's activities in the political arena.
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A 53-year-old patient with lymphoblastic lymphoma developed progressive interstitial pulmonary infiltrates. The patient was believed to have Pseudomonas bronchitis and was given parenteral gentamicin. Transbronchial lung biopsy performed through a fiberoptic bronchoscope was complicated by the development of Pseudomonas septicemia. The organism isolated on blood culture, like the one isolated on sputum culture, was fully susceptible to gentamicin in vitro. A prophylactic antimicrobial drug did not prevent bacteremic Pseudomonas infection in our immunosuppressed patient with pre-existent Pseudomonas bronchitis.
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Explore the source record for details and available documents.
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