Benzodiazepines and other psychotropic drugs abused by patients in a methadone maintenance program: familiarity and preference.
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Biomedical subjects
Publications and source records attributed to H Roessler.
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Physicians often face the problem that they have to treat anxiety and insomnia in patients who are dependent on narcotics or other substances. Reports about different reinforcing properties of different benzodiazepines and increasing concern about their misuse, often in combination with other drugs, call for studies that help to establish recommendations for choosing psychopharmacologic agents in the treatment of these patients. Opiate addicts enrolled in a methadone maintenance program were interviewed about their subjective "liking" of all psychotropic substances with which they had personal experience. The results confirm previous reports that certain benzodiazepines, especially flunitrazepam and diazepam, stand out from others in terms of positive reinforcing properties. Overall, the attractiveness of benzodiazepines as drugs of abuse for poly-drug abusers is lower than that of other sedative/hypnotics.
Plasma membranes of cells from lymph nodes of bovine leukaemia virus (BLV)-free cattle and of cells from tumorous lymph nodes of BLV-infected cattle have been investigated for their reactivity with iodine labelled BLV antigens gp51 and p24. It has been found that only the plasma membranes from cells of tumorous lymph nodes bound gp51 and p24. The binding could be abolished by addition of nonlabelled antigens. It has been calculated from Scatchard plot analysis that 10(5) molecules of gp51 or 10(4) molecules of p24 can be bound per tumour cell. The findings led to the conclusion that tumour cells of BLV-infected cattle are endowed with receptors for the BLV antigens gp51 and p24.
An ektoprosthesis with a synchronically movable, electronically controlled eyelid has been developed. A suitable trigger-signal is derived from the movement of the natural contralateral eyelid. The miniaturized electronic processing unit is intergrated into the spectracle frame. The artificial eyelid is moved by an electromagnet situated in the orbital cavity.
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