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Biomedical subjects

H Roll

Publications and source records attributed to H Roll.

12 recordsLinked to original sources
PubMed1980

Plasma levels of FSH and LH in patients with gonadal dysgenesis during sequential estrogen and progestogen therapy.

We describe the plasma levels of FSH and LH in ten patients with gonadal dysgenesis during treatment with a low dosage sequential estrogen-progestogen preparation. The daily dose of mestranol ranged from 12.5--50 microgram. Norethisterone was administered from day 16 onwards, the dose ranging between 0.75 and 1.5 mg. It was shown that 25 microgram mestranol was effective in lowering the elevated FSH levels significantly (alpha < 0.001). LH levels remained unaffected. The combination of 25 microgram mestranol and 1 mg norethisterone produced an increase of FSH and LH within 12 h, maximum levels being reached within 36 h after which there was a progressive decline. Low doses of estrogen and progestogen appeared capable of evoking physiological hypothalamic and pituitary responses in patients with gonadal dysgenesis. The doses employed were sufficient to induce breast development, growth of sexual hair, and withdrawal bleeding and were probably not high enough to induce rapid bone maturation and consequent stunting of growth.

Adolescent↗
PubMed1979

[The special case: squamous epithelial carcinoma of the cervix after cryotherapy in a 23 year old patient].

A case report is given of a 23 year old woman with an invasive squamous cancer of the uterine cervix 10 months after cryotherapy of an "ectopic area". The development in this case is reason for stressing the indispensable points in cryo-, thermo- and laser-therapy of the cervix: 1. proper pretherapeutic evaluation and documentation by means of cytology, colposcopy, and histology; 2. adequate extent of therapy; 3. exact follow-up after treatment.

Adult↗
PubMed1978

[Ultrasound and semiquantitative chorionic gonadotropin secretin in the diagnosis of abortion].

191 patients with signs of threatened abortion were assessed by means of ultrasound (Kretz-Technik, Vidoson, Siemens) and semiquantitative assay of urinary HCG-excretion. Sonar examination was able to establish an accurate diagnosis of fetal life (heart action and/or movements) in all pregnancies showing a gestation sac suitable to the 11th week. The remainder cases required a repeated investigation including HCG-levels and growth rate of the gestational sac. Thus the diagnosis of blighted ovum could be made within one or occassionally two weeks.

Abortion, Threatened↗
PubMed1975

Effects of C21 steroids on sex accessory organs and testes of mature hypophysectomized rats.

Adult hypophysectomized male rats were treated with 2 mg/day of testosterone propionate, pregnenolone, 17alpha-hydroxypregnenolone, progesterone or 17alpha-hydroxyprogesterone. The treatment commenced on the day of surgery and was continued for 4 weeks. In all steroid treated animals, spermatogenesis was qualitatively maintained. Sex accessory organs were maintained only in testosterone propionate treated animals. In C21 steroid-treated rats the sex accessory organs showed atrophy similar to untreated hypophysectomized animals suggesting lack of peripheral conversion to androgens. However, administration of 3H-pregnenolone with the last injection of pregnenolone resulted in the isolation of a considerable amount of 3H-testosterone from testicular tissue of the experimental animals. This finding suggests that maintenance of spermatogenesis in pregnenolone treated animals could have been due to testosterone formed in the testes from the exogenously administered pregnenolone.

17-alpha-Hydroxypregnenolone↗