PubMed Health⌕ Search

Biomedical subjects

H Roux

Publications and source records attributed to H Roux.

At least 37 records · Page 2Linked to original sources
PubMed1976

[Rheumatoid arthritis and trauma. 5 cases].

The authors report 5 cases of post-traumatic rheumatoid polyarthritis. After the traumatism had initiated the first stages of ordinary inflammation, chain reactions, perhaps by means of an "immune" field, intervened to transform it into a self-maintained rheumatoid inflammation. In fact, the etiopathogenic problems of post-traumatic rheumatoid polyarthritis have not yet been elucidated and it cannot be said either that the question of legal compensation for it is any nearer solution. The growing importance of traumatisms in everyday life and of compensation for them, and the gravity of the condition and its disabling sequelae require that great caution should be exercised in the search for criteria for attributing the disease to the traumatism: the almost indefinite evolution of the disease with time makes the choice of the consolidation date arbitrary.

Accidents, Occupational↗
PubMed1976

[Biological exploration of Paget's disease].

The laboratory investigation of cases of Paget's disease has revealed results of three types :--small increases in the sedimentation rate, in the ceruloplasmin level, in the average corpuscule volume, and in uricaemia. These changes are of little practical value;--a considerable increase in the common stocks and in the turn-over of calcium, a frequently negative assessment with a parathyroid hormone level at the lower limit of normality. The levels of calcaemia and calciuria, little changed on average, may increase slightly after hospitalization. The use of these parameters is valuable but they are sometimes difficult to interpret;--an increase in the levels of alkaline phosphatases and of urinary hydroxyproline, in relation to the extent and the activity of the disease, and also of certain parameters of calcium-45 and of quantitative histology. A statistical study of the spontaneous evolution of hydroxyprolinuria in 50 patients with Paget's disease who were not treated for less than 3 years, allowed the authors to establish in what conditions a change induced by calcitonin or mithramycin is significant.

Acid Phosphatase↗
PubMed1976

[Cyclical chemotherapy of myeloma with cell synchronization: therapeutic trial. Apropos of 13 cases].

The authors report the results obtained from the treatment of 13 cases of myeloma by cyclic chemotherapy (melphalan) applied after cellular synchronization with vincristine. The clinical results (maximum 2 years after treatment) were good in 11 cases out of 13. The following laboratory values quickly returned to normal: sedimentation and calcaemia, but there was little change in the immunoglobulins.

Aged↗
PubMed1976

[Early isotopic synoviorthesis during rheumatoid polyarthritis (RP)].

The authors report the results of 1258 chemical synovectomies carried out in subjects with rheumatoid polyarthritis on joints at Steinbrocker stage I and of 470 chemical synovectomies carried out during the first year of evolution of rheumatoid polyarthritis. Comparison with the results of chemical synovectomy carried out later demonstrate the superiority of early chemical synovectomy.

Arthritis, Rheumatoid↗
PubMed1976

[Experimental study of the synthesis of lysosomal enzymes by the synovial membrane: acid phosphatases].

In a system consisting of synovial samples taken surgically and maintained in culture, the authors studied the regulation of enzyme synthesis by taking acid phosphatase as the test enzyme. By means of double labelling and the use of protein synthesis inhibitors, they were able to demonstrate that this synthesis was stimulated by the addition of rheumatoid factor to the culture medium and that it depended on the transcription activity of the genome and on the translation of the information molecules.

Acid Phosphatase↗
PubMed1975

[Muscular involvement in rheumatic pelvispondylitis].

The authors explored a group of patients suffering from rheumatic pelvispondylitis from the point of view of muscular lesions: clinical muscular examination, anatomo-pathological investigation of the muscle (optical microscopy, histochemistry), electromyographic investigation, and determination of certain serum and muscle enzymes. Some muscular anomalies were observed, which were predominant in the muscles of the lumbar grooves, although there were some lesions of the quadriceps muscle, with a myogenous appearance, but without inflammation. The clearest anomalies were neurogenic and were present particularly in the muscles of the lumbar grooves.

Adult↗
PubMed1975

[Amyotrophy and neuronal depopulation of cerebral origin].

Amyotrophy of cerebral origin was analyzed in 12 hemiplegics by means of comparative histological, histoenzymological, histographic and biochemical analysis of biopsies carried out in symmetrical zones. In the 6 cases in which atrophy predominated on the paralyzed side, it occurred early, the deficiency affecting the upper limb in particular and the sensory disturbance being irregular. Attempted numeration of the motor units remaining, according to the "incremential" method of stimulation, suggests a numerical reduction on the hemipelgic side. Despite reservations and general criticisms of this method, its comparative value, although approximate, must be acknowledged. However, although amyotrophy presumes a transsynaptic change in trophic function to have taken place in the peripheral neurone, neuronal depopulation--if one accepts it--cannot be other than functional.

Aged↗
PubMed1975

[HL-A and Paget's disease].

In a study on 43 patients suffering from Paget's disease the authors grouped them within the HL-A histo-compatibility system. Twenty-nine antigens in this system were investigated. Comparison with the distribution in the population of France did not show a significant difference. Nevertheless, there appeared to be a greater frequency of the HL-A 5 and perhaps of W 22 antigens in patients suffering from generalized Paget's disease.

Female↗
PubMed1975

[Irregular agglutinins, hemolysins, antilymphocyte antibodies, serum anticomplementarity, human and species antiglobulins and cryoglobulins in a series of 33 patients with rheumatoid arthritis].

An immunological investigation was carried out on 33 rheumatoid polyarthritis patients. The phenomena of antierythrocytes immunization were investigated by standard tests : irregular agglutinins, haemolysins, and auto-antibodies which all proved negative. The lymphocyte immunological phenomena were also studied. Cold (4 degrees C) lymphocytotoxins were shown in 8 patients, 5 of whom had anti-lymphocyte auto-antibodies. The proportions of "sheep rosettes" were significantly reduced. The sera did not show notable anti-complementary activity. Studies on the human antiglobulins and on species antiglobulins were not very conclusive. Cryoglobulins were never detected. No clear correlation was found between these different tests and those of standard rheumatism serology.

Agglutinins↗
PubMedDate not supplied

[Hemopigmented villonodular synovitis].

Pigmented Villonodular Synovitis (PVNS) in an infrequent tumoral like disease and there are only a few MRI studies published. Concerning our series of five cases compared with the literature, the readers attention is drawn to the etiologies still under debate and to the respective contribution of the different imaging methods. MRI known for its high sensibility, but also for its low specificity in tumoral pathology, has turned out to be, in the case of PVNS, quite remarkable in both regards. The RMI aspect is quite well correlated to the histological structure of this synovial hyperplasia and to its evolution: highly vascular mass at the beginning and then low cellular density stroma, fibrous, with deposition of hemosiderin. In our five cases, as in almost all those previously reported in the literature, MR imaging shows heterogeneous areas of decreased signal intensity on T2 weighted sequences and on two of our cases after administration of gadolinium. Still the same MR aspects can be found in rheumatoid, hemophilic arthritis, as well as synovial chondromatosis, and therefore the clinical background and findings as well as plain films become essential. MR imaging should be the first examination to be undertaken after plain films, leading in most cases to a precise local preoperative assessment.

Female↗
PubMedDate not supplied

[Hyperlipemias and their manifestations in the rheumatological sphere].

It is fairly frequent to encounter hyperlipemia on a rheumatic unit. Firstly the symptoms of certain idiopathic hyperlipemias sometimes include rheumatic changes. The latter include firstly, arthritis and tendinitis, above all observed in Type II hyperlipoproteinemia but also mentionned in Type IV, and secondly, exceptional bony lesions (generally of xanthoma type) which seem to occur exclusively in severe hyperglyceridemia. A few bone and joint diseases, such as gout or aseptic necrosis, frequently coexist with dyslipemia. Furthermore, various diseases may be simultaneously responsible for secondary hyperlipemia and involvement of the locomotor apparatus. Finally, the iatrogenic manifestations of the locomotor system appear mainly due to hypolipemic drugs, e.g. the muscle disorders seen in a few patients treated with clofibrate.

Adrenocortical Hyperfunction↗
PubMedDate not supplied

[Importance of numeric scintigraphy of the hips during primary aseptic osteonecrosis of the femoral head in adults].

The authors have studied 58 cases of primitive aseptic osteonecrosis of the hips, 35 cases of coxarthrosis, 12 algodystrophies and 11 cases of coxitis, using numerical scintigraphy with Technetium 99m pyrophosphate. They have studied the ration of uptake by the femoral head over the uptake by the soft issues. The values obtained are compared to those observed in the study of normal hips. The result is that the technique offers the possibility of establishing, in a more differential manner, a diagnosis of lesion of the hips at an infraradiologic stage.

Adult↗
PubMedDate not supplied

[Results of the treatment of myeloma with a vincristine-melphalan combination].

The authors report the results obtained in a series of 20 multiple myelomas by an association Vincristin-Melphalan with a maximum therapeutic survival of 65 months. The median of survival is established at 27 months. The differences are a function of the initial values of the calcemia, the level of hemoglobin, the percentage of medullary plasmocytosis, but the essential factors appear to be the delay in the treatment, the stage of development established according to Salmon and Durie and particularly the presence or absence of a renal involvement. We have seen important fluctuations of certain immune parameters, particularly level of sheep rosettes and B cells detected by immunofluorescence.

Aged↗