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Biomedical subjects

H Rozenbaum

Publications and source records attributed to H Rozenbaum.

At least 19 recordsLinked to original sources
PubMed1989

Intra-uterine device failure: relation with drug use.

A case-control study was undertaken in order to test the relationship between commonly used anti-inflammatory agents and the efficacy of intra-uterine devices (IUDs). Women who had become pregnant while wearing an IUD were compared with non-pregnant IUD users. 717 cases and 717 controls were recruited from the same medical practices. The case-women (IUD failure) used anti-inflammatory drugs, particularly aspirin, more frequently than the controls (p less than 0.001). In contrast, oral progestins, taken in the second part of the cycle (16th to 25th day) were more frequently used by the control-women group (p less than 0.001). Although cases and controls differed in age and gravidity (younger and higher, respectively) standardization for these items did not change the findings for drug use.

Age Factors↗
PubMed1987

Immune basis for cimetidine-induced pancytopenia.

We report a case of a female patient with chronic myelogenous leukemia who presented, 8 yr after initial diagnosis, with pancytopenia, encephalopathy, and myalgia. The tentative diagnosis was accelerated phase of chronic myelogenous leukemia. However, because the patient had been treated with cimetidine for 7 months we first omitted this drug. When cimetidine was stopped, bone marrow recovered, and myalgia and encephalopathy subsided. Immunological studies showed stimulation of the patient's lymphocyte blastogenesis by cimetidine and a marked increase in the proportion of cytotoxic/suppressor T lymphocytes after incubation of peripheral blood lymphocytes with cimetidine for 6 days. These findings indicate a role for cell-mediated immunity in the pathogenesis of cimetidine-induced pancytopenia in this patient.

Aged↗
PubMed1985

[The menopause and vascular risk].

The vascular risk associated with the administration of oestrogens is admitted by the majority, denied by some, and is extremely difficult to assess. As a matter of fact, no vascular accident seems to have been published up to the present day with menopausal women treated with natural oestrogens. The analysis of populations permits one to suppose in the absence of large scale prospective and comparative statistics, that a correct case-finding of risk-factors, and regular surveillance should permit the reduction to a minimum of the probability of vascular accidents.

Arteriosclerosis↗