Biomedical subjects

H Rudolf

Publications and source records attributed to H Rudolf.

At least 19 recordsLinked to original sources

PubMed2002

[Self-help on the internet. Chances and risks of communication in electronic networks].

The worldwide web is used for self-help purposes by an increasing number of patients with a variety of mental disorders. The benefits and dangers of applying the internet in psychiatry are discussed based on a case report concerning a female with post traumatic stress and multiple personality disorders who visited a chat-room in the internet with two of her 48 supernumerary identities. During one stage of her history, she displayed an excessive use of the internet which must be considered a symptom of mental disorder rather than a distinct disease entity, viz. "internet addiction".

Behavior, Addictive↗

PubMed1999

Subjective quality of life in female in-patients with depression: a longitudinal study.

This study investigated Subjective Quality of Life (SQOL) in 42 women with depression, 70 women with alcoholism, and 73 women with schizophrenia within 3 weeks after hospital admission. Twenty-eight of the depressive patients were re-examined after 6 months. SQOL was assessed using the German version of the Lancashire Quality of Life Profile. On average, depressive women expressed dissatisfaction with life as a whole and with 4 out of 8 life domains, and had a lower SQOL than the other two diagnostic groups. Differences remain statistically significant when the influence of age and anxiety/depression is controlled for. SQOL in depressive women improved significantly within the follow up period. Positive SQOL change was moderately correlated with an improvement of depressive symptoms. The results indicate that depressive women after hospital admission express an unusually low SQOL, which seems to have some diagnostic specificity and improves over time. Changes in depressive symptoms do not fully explain SQOL changes.

Adolescent↗

PubMed1999

[Similarities and differences in subjective quality of life of alcoholic women].

OBJECTIVE: The present study examined quality of life of alcoholic women in detoxification. The study aimed at providing data in line with a so-called subject oriented evaluation and at finding ways for improving clinical care. METHODS: 70 alcoholic women were asked about their quality of life and about their need for qualities help. A follow-up study, six months later, examined the extent of relapse. RESULTS: Alcoholic women differ in their subjective quality of life. Subgroups, which differ regarding the structure of quality of life, also vary in age, job situation and finances, age of admission and their view on their alcohol dependence. They differ in their needs, too. Subjective quality of life predicts relapse. CONCLUSIONS: The findings suggest that subjective quality of life may be useful evaluation criterion. The assessment of quality of life may yield useful hints for therapeutic interventions.

Adult↗

PubMed1998

Do different subjective evaluation criteria reflect distinct constructs?

Four subjective evaluation criteria--self-rated symptoms, subjective quality of life, self-rated needs, and patients' assessment of treatment--were examined to determine whether they reflect distinct constructs and to what extent they are correlated. The four criteria were assessed in 90 newly admitted schizophrenia patients, 170 long-term-hospitalized schizophrenia patients, 154 patients with alcoholism admitted for the short term, and 68 patients with alcoholism in long-term rehabilitation, using identical instruments. The four criteria show substantial intercorrelations, except for assessment of treatment in the two acute treatment groups. One general factor explains between 43% and 55% of the variance in each group. Factor scores are associated with observer-rated psychopathology and objective data. The four criteria overlap in different patient groups, except in the assessment of treatment in acute groups. The use of more than one subjective criterion should occur only with specific hypotheses. A better theoretical framework is needed to explain the differences between and interrelationships of subjective evaluation criteria.

Adult↗

PubMed1994

[Persisting psychological disorders following harrassment because of an application to leave the GDR].

In an exploratory study we examined 40 patients, who had been exposed to harassment in the GDR because of an official application to leave and who suffered from persisting mental sequelae of that experience. On an average more than six years after termination of the stress situation in the GDR, patients showed a moderate anxious-depressive syndrome and vegetative complaints. Diagnostic classification varied; depressive disorders, posttraumatic stress disorder, somatoform and anxiety disorders were most often diagnosed. 45% of the patients stated that the symptoms were not mainly due to experiences during repression, and 43% saw a mainly positive effect of that experience on their life. The relevance of the findings is discussed briefly.

Adult↗

PubMed1993

[Psychological disorders after political imprisonment in East Germany--attitude of victims].

In an exploratory study we examined 55 patients who had been politically imprisoned in the GDR for at least six weeks and suffered from enduring mental sequelae of that imprisonment. Views of the patients were assessed by means of standardized open questions and rating scales. Patients reported on stressful conditions in prison, fears concerning the uncertain end of imprisonment, as well as on helpful aspects during and after imprisonment. In a cluster analysis two groups were separated: one group that found social relationships helpful for coping with their experiences and another one that did not feel helped by anybody in coping, 28% of the patients stated that the symptoms were not mainly due to experiences during imprisonment; 20% saw general positive effects of imprisonment on their life. Views of the patients were correlated with other variables such as psychopathological symptoms. The relevance of the findings is discussed briefly.

Adaptation, Psychological↗

PubMed1988

[Behavior of the basal and stimulated serum level of thyroid stimulating hormone and determination of thyroxine, thyroxine- binding capacity and free thyroxine index in females with chronic uremia].

In 11 female patients with chronic uraemia at the age of 20 to 47 years (average age 33.1 years) the basal and the thyrotropin releasing hormone-(TRH-) stimulated thyroid gland stimulating hormone-(SH-) secretion were investigated, in addition to this the parameters of the thyroid gland total thyroxin (T4), thyroxin binding capacity (TBC) as well as the free thyroxin-index (FT4-I). In 2 women the investigations were repeated after kidney transplantation. The determination of TSH and T4 was carried out radioimmunologically, TBC was determined according to the principle of the test tube analysis, whereas FT4-I was established by computation. In 9 of the 11 female patients with chronic uraemia a physiological TSH-response behaviour is existing, whereas for T4 deviations from the reference area are to be stated in 7 female patients and for FT4-I in 6 female patients.

Adult↗

PubMed1988

[Behavior of basal and stimulated serum levels of prolactin, growth hormone and gonadotropins in females with chronic uremia].

In 11 female patients with chronic uraemia at the age of 20 to 47 years (average age: 33.1 years) the behaviour of basal and stimulated serum levels of prolactin (PRL), growth hormone (HGH) and gonadotropins (LH, FSH) was investigated. For stimulation of the hormone secretion a sequential test with arginine hydrochloride, gonadotropin releasing hormone (GnRH) and thyrotropin releasing hormone (TRH) was used. In 2 women the investigations were repeated after kidney transplantation. The determination of LH, FSH, PRL and HGH was performed radioimmunologically. The investigations show that in women with chronic uraemia the basal LH-levels in general lie clearly above of those ones of women with biphasic cycles, whereas the FSH-levels are not increased. The LH-response after administration of 25 micrograms GnRH is adequate in 6 women and is absent in 5 women. After kidney transplantation a clear reduction of the basal LH-levels in comparison to the preliminary values is to be established. The increased basal LH-levels are causally made responsible for the disturbances of the menstrual cycle in women with chronic uraemia. For PRL hyper- and normoprolactinaemic as well as hypoprolactinaemic basal levels are found. A connection between the height of the PRL and creatinine levels cannot be proved. Apart from a adequate PRL response to the stimulation with TRH in the individual case this response is inadequate or is absent. The basal HGH-levels are in the area of reference. In all women HGH can adequately be stimulated, whereby the case in question is presumably a so-called paradoxical TRH-effect.

Adult↗

PubMed1988

[Basal and gonadotropin releasing hormone-stimulated gonadotropin secretion in patients with chronic uremia].

In 11 patients with chronic uremia both the basal and stimulated levels of LH and FSH in serum were determined by RIA. After renal transplantation the investigations were repeated in 2 cases. The basal levels of LH were unphysiologically increased whereas FSH was found in the normal range. The stimulation of LH by GnRH was adequate in 6 patients and in 5 there was no response. As a result of renal transplantation there was a drop of LH in serum. It is supposed that the unphysiological increase of LH in patients with chronic uremia is the cause for the disturbances of the menstrual cycle.

Adult↗

PubMed1988

[Basal and TRH stimulated TSH secretion and determination of total thyroxine (T4). Thyroxine-binding capacity and free thyroxine index (FT4-I) in patients with chronic uremia].

In 11 patients with chronic uremia both the basal and TRH stimulated TSH levels and T4, TBC and FT4-I were determined. The investigations were repeated in 2 cases after renal transplantation. TSH and T4 in serum were determined by RIA, TBC by radio reagent assay. FT4-I was calculated. In 8 patients the basal TSH levels were in the normo- and in 3 in the hypothyreotropic range. In 9 patients the response to TRH was adequate. There were deviations from the physiological range in 7 patients for T4 and in 6 for FT4-I.

Adult↗

PubMed1988

[Basal and stimulated secretion of prolactin and growth hormone in patients with chronic uremia].

In 11 patients with chronic uremia both the basal and the stimulated levels of PRL and HGH were determined by RIA. The investigations were repeated in 2 patients after renal transplantation. The basal PRL levels were as well hyper- and normoprolactinemic as hypoprolactinemic. Also the PRL response did not show any uniform tendency to the TRH stimulation. After renal transplantation in 1 patient there was a decrease of the hyperprolactinemic serum levels into the normoprolactinemic range whereas the response was not influenced to TRH. Both the basal and the stimulated levels of HGH were in the physiological range. The response of HGH to the stimulation is explained as the so-called paradox TRH effect underlined by missing of the stimulation after renal transplantation.

Adult↗

PubMed1987

[Results of the GnRH-TRH and arginine-GnRH-TRH test in females with hyperprolactinemic galactorrhea].

In 7 patients aged from 21 to 33 years (average age 24.6 years) with hyperprolactinemic galactorrhea a stimulation test with GnRH-TRH or arginine-GnRH-TRH was performed. The serum levels of LH, FSH, PRL, HGH, TSH and total thyroxine (T4) were determined by RIA, the thyroxine binding capacity (TBC) by radio agent assay. The free thyroxine index (FT4-I) was calculated. An adenoma of the pituitary gland was diagnosed in 3 patients by X-ray of sella turcica. In all patients there were disturbances of the menstrual cycle. Independent of the existence of an adenoma of the pituitary gland in all patients with high basal levels. PRL could not have been shown stimulated by TRH. On the other hand it could be shown that despite of high basal PRL-levels in serum there was a normal stimulation of the gonadotrophs in 5 patients. Out of one patient the stimulation of the thyreotropic cells of pituitary by TRH was normal, too, whereas there was no or an inadaquate stimulation of HGH by arginine in all patients.--T4, TBC and FT4-I showed no deviation from the normal range.

Adenoma↗

PubMed1987

[GnRH-TRH and arg-GnRH-TRH test in females with normoprolactinemic galactorrhea].

In 8 patients aged from 17 to 48 years (average age 32,6 years) with normoprolactinemic galactorrhea a stimulation test with GnRH-TRH or arginine-GnRH-TRH was performed. The basal and stimulated serum levels of LH, FSH, PRL, TSH, HGH and total thyroxine (T4), the thyroxine binding capacity (TBC) and the free thyroxine index (FT4-I) were determined. -In a few cases there were disturbances of both the basal and the stimulated serum levels of the hormones. -Both the menstrual disorders which were seen in all patients with galactorrhea and the hormonal disturbances are discussed in context of an hypothetical increase of the PRL receptor sensibility in face of normal PRL serum levels or as a hint at a transient hyperprolactinemia.

Adolescent↗

PubMed1986

[Budd-Chiari syndrome and Vaquez disease: apropos of a case. Results of medical and surgical treatment of Budd-Chiari syndrome].

A case is reported of polycythaemia vera associated with Budd-Chiari syndrome. Anticoagulant treatment produced a favorable outcome. A review of the literature prompts the conclusion that in the context of polycythaemia vera surgery does not produce better results than a purely medical approach. We therefore feel that in the type of patient we report, anticoagulation should be maintained for as long as possible.

Adult↗

PubMed1986

[Effect of mestranol and chlormadinone acetate on TSH, T4, TBC and FT4 index in Turner syndrome].

In 19 patients with Turner's syndrome aged from 12 to 24 years (average age 17.0 years) the influence of mestranol and chlormadinone acetate on both basal and TRH stimulated TSH secretion, total thyroxine (T4), thyroxine binding capacity (TBC) and free thyroxine index (FT4-I) by means of sequential stimulation test (0.5 g arginine hydrochloride/kg body weight, 25 micrograms GnRH and 200 micrograms TRH) was investigated. These investigations were performed before hormonal substitution, during third to 5th cycles of treatment and 4 month after finishing treatment. TSH and T4 serum levels were determined by RIA, TBC by radio reagent assay. The FT4 index was calculated. Mean basal TSH levels both before, during and after hormonal treatment did not differ. Netto TSH level increase were somewhat higher in 8 of the 19 patients during hormonal treatment. TBC and T4 significantly increased under treatment. The rise of FT4 in a few patients under treatment could not be ensured statistically. After finishing treatment the levels of thyroid parameters decreased.

Adolescent↗

PubMed1985

[Theoretical principles and personal experiences in the use of a sequential stimulation test with arginine, gonadotropin-releasing hormone and thyrotropin-releasing hormone in healthy probands].

The theoretical bases and the performance of a sequential stimulation test (SST) with 0.5 g arginine hydrochloride per kg body weight, 25 micrograms gonadotropin-releasing hormone and 200 micrograms thyreotropin-releasing hormone are described. The result of SST is shown for 17 healthy women with biphasic cyclus. Beside the basal hormone levels B (hypo-, normo- or hyperhormonal) the response A (no, inadaquate or adaquate response) to the stimulation resulting from the peak levels and netto increases is a valuation criteria.

Adolescent↗

PubMed1985

[Effect of ethinyl estradiol sulfonate/norethisterone acetate on TSH, T4, TBC and the FT4 index in pubertal girls].

In 13 healthy tall girls the influence of the hormonal treatment with depotestrogen ethinylestradiolsulfonate and norethisterone acetate on basal and TRH stimulated TSH secretion, total thyroxine (T4), thyroxine binding capacity (TBC) and free thyroxine index (FT4 index) was investigated. The investigations were performed before treatment, during the 8th to 11th cycles of treatment, and in the 4th month after finishing the therapy. TSH and T4 serum levels were determined by RIA, TBC by radio agent assay, the FT4 index was calculated. The mean basal TSH levels before, during and after therapy showed no significant differences. During hormonal therapy T4, TBC and FT4 were significant higher (p less than 0.05) than before and after therapy.

Adolescent↗

PubMed1985

[Behavior of the hypothalamo-hypophyseal unit to stimulation with arginine, GnRH and TRH in patients with chronic uremia].

In 11 women aged from 20 to 47 years (average age 33,1 years) with chronic uremia, treated by hemodialysis, a sequential stimulation test (SST) with 0.5 g arginine hydrochloride per kg body weight, 25 micrograms GnRH and 200 micrograms TRH was performed to examine the responsibility of the hypothalamo-pituitary unit. For evaluation of basal and stimulated secretion of PRL, LH, FSH, TSH, and HGH the corresponding serum levels were determined by RIA. 10 of the 11 women showed a galactorrhoea. No correlation between levels of PRL and creatinine could be found. Menstrual disorders in women with chronic uremia are discussed in the context of basal LH serum levels nearly always unphysiologically increased. In a few cases disturbances of basal secretion of TSH and HGH, respectively, could be observed.

Adult↗