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Biomedical subjects

H S Cecil

Publications and source records attributed to H S Cecil.

5 recordsLinked to original sources
PubMed1987

Referral practices and attitudes of pediatricians toward young mentally retarded children.

Pennsylvania pediatricians were interrogated through a questionnaire about their referral practices with and attitudes toward mildly and moderately delayed preschool children. Whereas most sought a diagnostic evaluation for those children functioning at half their chronological age, they did not refer less seriously retarded youngsters during the preschool years, despite favorable support for early intervention. The reluctance to diagnose and label may result from pediatricians' perceptions of what mental retardation means. For the most part, the respondents have the view-at variance with major organizational definitions-that retardation implies neurological dysfunction and a chronic irreversible status. Low IQ secondary to emotional or social conditions, on the other hand, is not perceived as retardation, and is considered remediable. The attitudes and practices are discussed in light of empirical research outcomes with handicapped children and the fixity of organically determined deficits.

Adult↗
PubMed1984

Early intervention with retarded children: some encouraging results.

The changes in IQ for 35 preschool retarded children evaluated and then treated in a special hospital-based program which emphasized parent participation were compared with those of 36 retarded children evaluated at the same hospital clinic, most of whom received preschool services in the community. Over an average of 16 months, the group in the hospital-based program showed a mean gain of 8.1 IQ points, and 11 children increased by 15 points or more. In contrast, the mean improvement for the community group was 0.8 IQ points, and only two children had increases of 15 points or more. With the exception of serious neglect/deprivation, there was no relationship between medical diagnosis and amount of IQ change. Children from backgrounds of poverty, with unknown and presumably non-biological etiologies, did no better than children in better social circumstances with clear organic causes. Outcome was unaffected by sex, initial IQ level, initial age or social class.

Autistic Disorder↗
PubMedDate not supplied

Aspirin-induced hepatotoxicity in juvenile rheumatoid arthritis. A prospective study.

Recent reports of and our own experience with biochemical alterations of liver function secondary to salicylate therapy stimulated this prospective study. Thirty-four children with juvenile rheumatoid arthritis, 6 children with acute cartilagenous necrosis of the hipfollowing slipped capital femoral epiphysis, and 2 children with ulcerative colitis and hip disease who were on salicylates were followed over a period of 1-27 months with serial determinations of serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), lactic dehydrogenase (LDH), alkaline phosphatase (AP), bilirubin, and serum salicylate. Prothrombin time was measured in 14 children. Twenty-two of 34 children with rheumatoid arthritis and none of the 8 controls demonstrated abnormalities of various liver functions at serum salicylate levels between 7.0 and mg%. Three children demonstrated severe abnormalities characterized by marked elevation of SGOT, SGPT, LDH, and AP, prolongation of prothrombin time, and epistaxis. This type of reaction occurred within 5-14 days of initiation of aspirin therapy and occurred at serum salicylate levels between 18 and 43 mg%. Moderate changes in various liver function tests were observed in 19 other children. None of those children who were tested showed prolongation of prothrombin time. The serum salicylate level in this group varied between 7.0 and 38.2 mg%. The abnormal liver function tests returned to normal in 6 children upon withdrawal of aspirin and in 12 others even when salicylates were continued. Therefore, despite the occurrence of biochemical abnormalities following chronic salicylate therapy, it does not appear to be necessary to discontinue their use except in those children who develop bleeding.

Alanine Transaminase↗